European Food Safety Authority

Glyphosate: Cancer and Other Health Concerns

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Posted on by Carey Gillam

Glyphosate, a synthetic herbicide patented in 1974 by the Monsanto Company and now manufactured and sold by many companies in hundreds of products, has been associated with cancer and other health concerns. Glyphosate is best known as the active ingredient in Roundup-branded herbicides, and the herbicide used with “Roundup Ready” genetically modified organisms (GMOs).

Herbicide tolerance is the most prevalent GMO trait engineered into food crops, with some 90% of corn and 94% of soybeans in the U.S. engineered to tolerate herbicides, according to USDA data. A 2017 study found that Americans’ exposure to glyphosate increased approximately 500 percent since Roundup Ready GMO crops were introduced in the U.S in 1996. 

Why is Bayer taking glyphosate off the U.S. consumer market?

In July 2021, Monsanto owner Bayer AG said it would remove glyphosate-based herbicides from the U.S. consumer market by 2023 due to litigation. More than 100,000 people are suing Bayer alleging they developed non-Hodgkin lymphoma from exposure to the company’s glyphosate herbicides, such as Roundup. For more information about the lawsuits and documents released via discovery, see our Monsanto Papers page. 

How much glyphosate is used around the world? 

According to a February 2016 study, glyphosate is the most widely used pesticide: “In the U.S., no pesticide has come remotely close to such intensive and widespread use.” Findings include:

  • Americans applied 1.8 million tons of glyphosate (or 1.6 billion kilograms) from its introduction in 1974 to 2014. 
  • Worldwide 9.5 million tons (or 8.6 billion kilograms) of the chemical has been sprayed on fields – enough to spray nearly half a pound of Roundup on every cultivated acre of land in the world.
  • Globally, glyphosate use has risen almost 15-fold since Roundup Ready GMO crops were introduced. 

In the U.S., approximately 281 million pounds of glyphosate were applied to 298 million acres annually, on average, from 2012 to 2016, according to the Environmental Protection Agency. Most glyphosate was applied to soybean (117.4 million pounds applied annually), corn (94.9 million pounds annually), and cotton (20 million pounds annually). Many citrus fruits, including grapefruit, oranges and lemons, and field crops such as soybeans, corn and cotton have  high percentages of their acres treated with glyphosate.

Approximately 24 million pounds of glyphosate are applied to non-agricultural sites annually, according to EPA.  The majority of non-agricultural use is in the homeowner market. About 5 million pounds is applied annually for residential use.

What do scientists and health care providers say about glyphosate? 

Many scientists, health care professionals and public interest groups have raised concern about the health impacts of glyphosate. Here are some key statements: 

Monsanto owner Bayer AG maintains that glyphosate and glyphosate-based herbicides are safe when used as directed and do not cause cancer.  “Glyphosate is one of the most studied herbicides in the world – and, like all crop protection products, it is subject to rigorous testing and oversight by regulatory authorities,” Bayer states on its website. “There is an extensive body of research on glyphosate and glyphosate-based herbicides…  that confirm that glyphosate and our glyphosate-based formulated products can be used safely and do not cause cancer.”  

How much glyphosate is in our bodies? 

More than 80% of urine samples drawn from children and adults in a U.S. health study contained glyphosate, according to data from the U.S. Centers for Disease Control and Prevention. Out of 2,310 urine samples taken from Americans intended to be representative of the population, CDC found that 1,885 contained detectable levels of glyphosate. Scientists described this finding as “disturbing” and “concerning.”

A 2017 study in JAMA found that Americans’ exposure to glyphosate increased approximately 500 percent since Roundup Ready GMO crops were introduced in the U.S in 1996. 

While it is clear that most Americans are being exposed to glyphosate, the literature on glyphosate exposure levels, especially in children, remains limited, according to a 2020 paper in Environmental Health.  “Without more data collected in a standardized way, parsing out the potential relationship between glyphosate exposure and disease will not be possible,” the researchers concluded.

Why are corporate studies a problem? 

Regulators in Europe and the United States, Canada and elsewhere have repeatedly affirmed the corporate assertions of glyphosate safety. In making determinations about safety, these regulators have relied in part on tests that are conducted by or for the companies that have not been published or peer reviewed.  

The corporate studies have long been kept secret, even by regulators. But in Europe, litigation by a group of European Parliament lawmakers led to the release of dozens of such studies. More than 50 of those corporate studies were analyzed in 2021 by two independent scientists – Armen Nersesyan and Siegfried Knasmueller, both from the Institute of Cancer Research, Department of Medicine at the Medical University of Vienna.

The goal of the analysis was to determine if the industry studies examined comply with current international guidelines for chemical testing. 

The resulting analysis was released July 2, 2021 and concluded that the bulk of the industry studies were outdated and did not meet current guidelines. An array of shortcomings and flaws were found in the studies, rendering most of them unreliable, according to the analysis.

In fact, of the 53 studies submitted to regulators by the companies, only two were acceptable under current internationally recognized scientific standards, said Knasmueller. See more details here. 

What do scientific and regulatory agencies say about glyphosate and cancer?

The scientific literature and regulatory conclusions regarding cancer links to glyphosate and glyphosate-based herbicides show a mix of findings, making the safety of the herbicide a hotly debated subject. 

In 2015, the World Health Organization’s International Agency for Research on Cancer (IARC) classified glyphosate as “probably carcinogenic to humans” after reviewing years of published and peer-reviewed scientific studies. The team of international scientists found there was a particular association between glyphosate and non-Hodgkin lymphoma.

U.S. agencies: At the time of the IARC classification, the Environmental Protection Agency (EPA) was conducting a registration review. The EPA’s Cancer Assessment Review Committee (CARC) issued a report in September 2016 concluding that glyphosate was “not likely to be carcinogenic to humans” at doses relevant to human health. In December 2016, the EPA convened a Scientific Advisory Panel to review the report; members were divided in their assessment of EPA’s work, with some finding the EPA erred in how it evaluated certain research. Additionally, the EPA’s Office of Research and Development determined that EPA’s Office of Pesticide Programs had not followed proper protocols in its evaluation of glyphosate, and said the evidence could be deemed to support a “likely” carcinogenic or “suggestive” evidence of carcinogenicity classification. Nevertheless the EPA issued a draft report on glyphosate in December 2017 continuing to hold that the chemical is not likely to be carcinogenic. In April 2019, the EPA reaffirmed its position that glyphosate poses no risk to public health. But earlier that same month, the U.S. Agency for Toxic Substances and Disease Registry (ATSDR) reported that there are links between glyphosate and cancer. According to the draft report from ATSDR, “numerous studies reported risk ratios greater than one for associations between glyphosate exposure and risk of non-Hodgkin’s lymphoma or multiple myeloma.” The report was finalized in August 2020. 

The EPA issued an Interim Registration Review Decision in January 2020 with updated information about its position on glyphosate, continuing to hold the position that glyphosate is unlikely to cause cancer. In June 2022, the Ninth Circuit Court of Appeals rejected EPA’s decision that glyphosate likely poses no “unreasonable risk” to the environment and human health. EPA withdrew its interim decision in September 2022 and the agency will start over in its review. 

European Union: The European Food Safety Authority and the European Chemicals Agency have said glyphosate is not likely to be carcinogenic to humans. A March 2017 report by environmental and consumer groups argued that regulators relied improperly on research that was directed and manipulated by the chemical industry. A 2019 study found that Germany’s Federal Institute for Risk Assessment report on glyphosate, which found no cancer risk, included sections of text that had been plagiarized from Monsanto studies.  In February 2020, reports surfaced that 24 scientific studies submitted to the German regulators to prove the safety of glyphosate came from a large German laboratory that has been accused of fraud and other wrongdoing.

In June 2021, the European Union’s (EU) Assessment Group on Glyphosate (AGG) issued an 11,000-page draft report concluding that glyphosate is safe when used as directed and does not cause cancer. The finding is based in part on a dossier of roughly 1,500 studies submitted to European regulators by the “Glyphosate Renewal Group (GRG),” a collection of companies that includes Monsanto owner Bayer AG. The companies are seeking the renewal of the EU authorization of glyphosate. Current authorization in Europe expires in December 2022. The companies say they also gave regulators a “literature review” of around 12,000 published scientific articles on glyphosate.

WHO/FAO Joint Meeting on Pesticide Residues determined in 2016 that glyphosate was unlikely to pose a carcinogenic risk to humans from exposure through the diet, but this finding was tarnished by conflict of interest concerns after it came to light that the chair and co-chair of the group also held leadership positions with the International Life Sciences Institute, a group funded in part by Monsanto and one of its lobbying organizations.

California OEHHA: On March 28, 2017, the California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment confirmed it would add glyphosate to California’s Proposition 65 list of chemicals known to cause cancer. Monsanto sued to block the action but the case was dismissed. In a separate case, the court found that California could not require cancer warnings for products containing glyphosate. On June 12, 2018, a U.S. District Court denied the California Attorney General’s request for the court to reconsider the decision. The court found that California could only require commercial speech that disclosed “purely factual and uncontroversial information,” and the science surrounding glyphosate carcinogenicity was not proven.

Agricultural Health Study: A long-running U.S. government-backed prospective cohort study of farm families in Iowa and North Carolina has not found any connections between glyphosate use and non-Hodgkin lymphoma, but the researchers reported that “among applicators in the highest exposure quartile, there was an increased risk of acute myeloid leukemia (AML) compared with never users…” The most recent published update to the study was made public in late 2017.

What health problems are linked to glyphosate exposure? 

Cancer

Endocrine disruption, fertility and reproductive concerns 

Kidney disease 

The American Association for the Advancement of Science awarded two Sri Lankan scientists, Drs. Channa Jayasumana and Sarath Gunatilake, the 2019 Award for Scientific Freedom and Responsibility for their work to “investigate a possible connection between glyphosate and chronic kidney disease under challenging circumstances.” The scientists reported that glyphosate plays a key role in transporting heavy metals to the kidneys of those drinking contaminated water, leading to high rates of chronic kidney disease in farming communities.  

The AAAS award to the scientists had been suspended amidst a fierce opposition campaign by pesticide industry allies to undermine the work of the scientists. After a review, the AAAS reinstated the award.

Liver disease 

  • A 2017 study associated chronic, very low-level glyphosate exposures to non-alcoholic fatty liver disease in rats. According to the researchers, the results “imply that chronic consumption of extremely low levels of a GBH formulation (Roundup), at admissible glyphosate-equivalent concentrations, are associated with marked alterations of the liver proteome and metabolome,” the biomarkers for NAFLD.

Microbiome disruption

  • November 2020 paper in the Journal of Hazardous Materials reports that approximately 54 percent of species in the core of the human gut microbiome are “potentially sensitive” to glyphosate. With a “large proportion” of bacteria in the gut microbiome susceptible to glyphosate, the intake of glyphosate “may severely affect the composition of the human gut microbiome,” the authors said in their paper. 
  • A 2020 literature review of glyphosate’s effects on the gut microbiome concludes that, “glyphosate residues on food could cause dysbiosis, given that opportunistic pathogens are more resistant to glyphosate compared to commensal bacteria.” The paper continues, “Glyphosate may be a critical environmental trigger in the etiology of several disease states associated with dysbiosis, including celiac disease, inflammatory bowel disease and irritable bowel syndrome. Glyphosate exposure may also have consequences for mental health, including anxiety and depression, through alterations in the gut microbiome.”
  • A 2018 rat study conducted by the Ramazzini Institute reported that low-dose exposures to Roundup at levels considered safe significantly altered the gut microbiota in some of the rat pups.
  • Another 2018 study reported that higher levels of glyphosate administered to mice disrupted the gut microbiota and caused anxiety and depression-like behaviors.

Neurotoxicity

  • A large nationwide study published in the journal NeuroToxicology (December 2021) reports that “several neurotoxic pesticide exposures estimated using residential location were associated with statistically significant increased risk of ALS (amyotrophic lateral sclerosis). These include the herbicides 2,4-D and glyphosate, and the insecticides carbaryl and chlorpyrifos.” ALS is a progressive nervous system disease that affects nerve cells in the brain and spinal cord, causing loss of muscle control. 

What are the environmental impacts of glyphosate?

Harm to bees and monarch butterflies

Why are people suing Bayer over glyphosate?

More than 100,000 people have filed suit against Monsanto Company (now Bayer) alleging that exposure to Roundup herbicide caused them or their loved ones to develop non-Hodgkin lymphoma (NHL), and that Monsanto covered up the risks. As part of the discovery process, Monsanto has had to turn over millions of pages of internal records. We are posting these Monsanto Papers as they become available. The first three trials ended in large awards to plaintiffs for liability and damages, with juries ruling that Monsanto’s weed killer was a substantial contributing factor in causing them to develop NHL. Bayer is appealing the rulings. The U.S. Supreme Court has so far upheld the rulings against Bayer. 

Monsanto influence in research

In March 2017, the federal court judge unsealed some internal Monsanto documents that raised new questions about Monsanto’s influence on the EPA process and about the research regulators rely on. The documents suggest that Monsanto’s long-standing claims about the safety of glyphosate and Roundup do not necessarily rely on sound science as the company asserts, but on efforts to manipulate the science. 

More information about scientific interference

Why is desiccation of wheat and other crops a problem?

Some farmers use glyphosate on non-GMO crops such as wheat, barley, oats, and lentils to dry down the crop ahead of harvest in order to accelerate the harvest. This practice, known as desiccation, may be a significant source of dietary exposure to glyphosate.

How much glyphosate is in our food? 

Despite having annual pesticide residue testing programs for more than 30 years, the USDA U.S. FDA mostly skipped testing food for glyphosate until after criticism from the Government Accountability Office in 2014. The USDA said it would start testing but then dropped the plan in 2017. Internal government documents obtained by U.S. Right to Know show USDA had planned to start testing over 300 samples of corn syrup for glyphosate in April 2017; but the agency killed the project before it started. FDA began a limited testing program in 2016, but the effort was fraught with controversy and internal difficulties and the program was suspended in September 2016. The FDA did later resume limited testing. 

One FDA chemist found alarming levels of glyphosate in many samples of U.S. honey, levels that were technically illegal because there have been no allowable levels established for honey by the EPA. Here is a recap of news about glyphosate found in food:

What mixtures of glyphosate and other pesticides are in our food? 

USDA data from 2016 shows detectable pesticide levels in 85% of more than 10,000 foods sampled, everything from mushrooms to grapes to green beans. The government says there are little to no health risks, but some scientists say there is little to no data to back up that claim. See “Chemicals on our food: When “safe” may not really be safe: Scientific scrutiny of pesticide residue in food grows; regulatory protections questioned.”

In 2020, a group of FDA scientists published a research paper  examining pesticide residue data collected from 2009-2017. The scientists said this: “In this study, results for over 56,000 human food samples collected and analyzed under the FDA pesticide residue monitoring program between fiscal years (FY) 2009 to 2017 were reviewed to identify trends not apparent in annual reports. The overwhelming majority of these samples, 98.0% of domestic and 90.9% of import human foods, were compliant with federal standards. Although herbicides may be more widely used, the 10 most frequently detected residues were insecticides and fungicides. On a yearly basis, the violation rate for imported samples is 3-5 times higher than the rate for domestic samples. The import violation rate increased over time, as did the number of residues detected. Targeted sampling of foods with higher commodity-specific violation rates appears to be a major contributor to the increased violation rate. Mismatches between US tolerances and international MRLs can lead to violations; this was especially marked for rice. Overall, the majority of violations are due to residues of pesticides not authorized for use in the US (lack of tolerances). While DDT continues to persist in the environment and was found in 2.2% of domestic samples and 0.6% of imported samples, 42.3% of DDT-positive samples were below the limit of quantitation. The trends and analyses identified in this paper may help FDA plan future sampling and continue to protect the food supply.”

Monsanto owner Bayer AG maintains that residues of glyphosate in food are not harmful at levels approved by the Environmental Protection Agency.  A 2021 paper written by longtime Bayer (former Monsanto) scientist John Vicini and published in Comprehensive Reviews in Food Science and Food Safety states that  “dietary exposures to glyphosate are within established safe limits.” 

For a complete history of the use of glyphosate, including regulatory action and inaction, scientific controversies, human and environmental impact data, read Whitewash – The Story of a Weed Killer, Cancer and the Corruption of Science, winner of the 2018 Rachel Carson Book Award from the Society of Environmental Journalists.

This fact sheet was updated July 13, 2022 by USRTK staff

Reuters report that IARC ‘edited out’ findings is a false narrative

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Posted on by Stacy Malkan

Updates: New Monsanto documents expose cozy connection to Reuters Reporter, Roundup Trial Tracker (April 25, 2019)
IARC rejects false claims in Reuters article, statement by the International Agency for Research on Cancer (October 24, 2017)

Original date of post: October 20, 2017

Continuing her record of industry-biased reporting about the International Agency for Research on Cancer (IARC), Reuters reporter Kate Kelland again attacked the cancer agency with an October 19, 2017 story claiming the scientists edited a draft document before issuing their final assessment that classified glyphosate as a probable human carcinogen. The American Chemistry Council, the chemical industry trade group, immediately issued a press release praising Kelland’s story, claiming it “undermines IARC’s conclusions about glyphosate” and urging policy makers to “take action against IARC over deliberate manipulation of data.”

Kelland’s story quoted a Monsanto executive claiming that “IARC members manipulated and distorted scientific data” but failed to mention the significant amount of evidence that has emerged from Monsanto’s own documents through court-ordered discovery that demonstrate the many ways the company has worked to manipulate and distort data on glyphosate over decades.

The story also failed to mention that most of the research IARC discounted was Monsanto-financed work that did not have sufficient raw data to meet IARC’s standards. And though Kelland cites a 1983 mouse study and a rat study in which IARC failed to agree with the original investigators, she failed to disclose that these were studies financed by Monsanto. She also failed to mention the critical information that in the 1983 mouse study, even the EPA toxicology branch did not agree with Monsanto’s investigators because the evidence of carcinogenicity was so strong, according to EPA documents. They said in numerous memos that Monsanto’s argument was unacceptable and suspect, and they determined glyphosate to be a possible carcinogen.

By leaving out these crucial facts, and by twisting others almost inside out, Kelland has authored another article that serves Monsanto quite well, but misled the public and policy makers who rely on trusted news outlets for accurate information. The only encouraging point to be taken from Kelland’s story is that this time she admitted Monsanto provided her with the information.

Related stories and documents:

Reuters vs. UN Cancer Agency: Are Corporate Ties Influencing Science Coverage?

By Stacy Malkan

Ever since they classified the world’s most widely used herbicide as “probably carcinogenic to humans,” a team of international scientists at the World Health Organization’s cancer research group have been under withering attack by the agrichemical industry and its surrogates.

In a front-page series titled “The Monsanto Papers,” the French newspaper Le Monde (6/1/17) described the attacks as “the pesticide giant’s war on science,” and reported, “To save glyphosate, the firm [Monsanto] undertook to harm the United Nations agency against cancer by all means.”

With two industry-fed scoops and a special report, reinforced by her regular beat reporting, Kelland has aimed a torrent of critical reporting at the WHO’s International Agency for Research on Cancer (IARC), portraying the group and its scientists as out of touch and unethical, and leveling accusations about conflicts of interest and suppressed information in their decision-making.One key weapon in industry’s arsenal has been the reporting of Kate Kelland, a veteran Reuters reporter based in London.

The IARC working group of scientists did not conduct new research, but reviewed years of published and peer-reviewed research before concluding that there was limited evidence of cancer in humans from real-world exposures to glyphosate and “sufficient” evidence of cancer in studies on animals. IARC also concluded there was strong evidence of genotoxicity for glyphosate alone, as well as glyphosate used in formulations such as Monsanto’s Roundup brand of herbicide, whose use has increased dramatically as Monsanto has marketed crop strains genetically modified to be “Roundup Ready.”

But in writing about the IARC decision, Kelland has ignored much of the published research backing the classification, and focused on industry talking points and criticisms of the scientists in seeking to diminish their analysis.  Her reporting has relied heavily on pro-industry sources, while failing to disclose their industry connections; contained errors that Reuters has refused to correct; and presented cherry-picked information out of context from documents she did not provide to her readers.

Raising further questions about her objectivity as a science reporter are Kelland’s ties to the Science Media Centre (SMC), a controversial nonprofit PR agency in the UK that connects scientists with reporters, and gets its largest block of funding from industry groups and companies, including chemical industry interests.

SMC, which has been called “science’s PR agency,” launched in 2002 partly as an effort to tamp down news stories driven by groups like Greenpeace and Friends of the Earth, according to its founding report. SMC has been accused of playing down the environmental and human health risks of some controversial products and technologies, according to multiple researchers who have studied the group.

Kelland’s bias  in favor of the group is evident, as she appears in the SMC promotional video and the SMC promotional report, regularly attends SMC briefings, speaks at SMC workshops and attended meetings in India to discuss setting up an SMC office there.

Neither Kelland nor her editors at Reuters would respond to questions about her relationship with SMC, or to specific criticisms about her reporting.

Fiona Fox, director of SMC, said her group did not work with Kelland on her IARC stories or provide sources beyond those included in SMC’s press releases. It is clear, however, that Kelland’s reporting on glyphosate and IARC mirrors the views put forth by SMC experts and industry groups on those topics.

Reuters takes on cancer scientist

On June 14, 2017, Reuters published a special report by Kelland accusing Aaron Blair, an epidemiologist from the US National Cancer Institute and chair of the IARC panel on glyphosate, of withholding important data from its cancer assessment.

Kelland’s story went so far as to suggest that the information supposedly withheld could have changed IARC’s conclusion that glyphosate is probably carcinogenic. Yet the data in question was but a small subset of epidemiology data gathered through a long-term project known as the Agricultural Health Study (AHS). An analysis of several years of data about glyphosate from the AHS had already been published and was considered by IARC, but a newer analysis of unfinished, unpublished data was not considered, because IARC rules call for relying only on published data.

Kelland’s thesis that Blair withheld crucial data was at odds with the source documents on which she based her story, but she did not provide readers with links to any of those documents, so readers could not check the veracity of the claims for themselves. Her bombshell allegations were then widely circulated, repeated by reporters at other news outlets (including Mother Jones) and immediately deployed as a lobbying tool by the agrichemical industry.

After obtaining the actual source documents, Carey Gillam, a former Reuters reporter and now research director of US Right to Know (the nonprofit group where I also work), laid out multiple errors and omissions in Kelland’s piece.

The analysis provides examples of key claims in Kelland’s article, including a statement supposedly made by Blair, that are not supported by the 300-page deposition of Blair conducted by Monsanto’s attorneys, or by other source documents.

Kelland’s selective presentation of the Blair deposition also ignored what contradicted her thesis—for example, Blair’s many affirmations of research showing glyphosate’s connections to cancer, as Gillam wrote in a Huffington Post article (6/18/17).

Kelland inaccurately described Blair’s deposition and related materials as “court documents,” implying they were publicly available; in fact, they were not filed in court, and presumably were obtained from Monsanto’s attorneys or surrogates. (The documents were available only to attorneys involved in the case, and plaintiff’s attorneys have said they did not provide them to Kelland.)

Reuters has refused to correct the errors in the piece, including the false claim about the origin of the source documents and an inaccurate description of a key source, statistician Bob Tarone, as “independent of Monsanto.” In fact, Tarone had received a consultancy payment from Monsanto for his efforts to discredit IARC.

In response to a USRTK request to correct or retract the Kelland article, Reuters global enterprises editor Mike Williams wrote in a June 23 email:

We have reviewed the article and the reporting on which it was based. That reporting included the deposition to which you refer, but was not confined to it. The reporter, Kate Kelland, was also in contact with all the people mentioned in the story and many others, and studied other documents. In the light of that review, we do not consider the article to be inaccurate or to warrant retraction.

Williams declined to address the false citing of “court documents” or the inaccurate description of Tarone as an independent source.

Since then, the lobbying tool Reuters handed to Monsanto has grown legs and run wild. A June 24 editorial by the St. Louis Post Dispatch added errors on top of the already misleading reporting. By mid-July, right-wing blogs were using the Reuters story to accuse IARC of defrauding US taxpayers, pro-industry news sites were predicting the story would be “the final nail in the coffin” of cancer claims about glyphosate, and a fake science news group was promoting Kelland’s story on Facebook with a phony headline claiming that IARC scientists had confessed to a cover-up.

Bacon attack

This was not the first time Kelland had relied on Bob Tarone as a key source, and failed to disclose his industry connections, in an article attacking IARC.

An April 2016 special investigation by Kelland, “Who Says Bacon Is Bad?,” portrayed IARC as a confusing agency that is bad for science. The piece was built largely on quotes from Tarone, two other pro-industry sources whose industry connections were also not disclosed, and one anonymous observer.

IARC’s methods are “poorly understood,” “do not serve the public well,” sometimes lack scientific rigor, are “not good for science,” “not good for regulatory agencies” and do the public “a disservice,” the critics said.

The agency, Tarone said, is “naïve, if not unscientific”—an accusation emphasized with capital letters in a sub-headline.

Tarone works for the pro-industry International Epidemiology Institute, and was once involved with a controversial cell phone study, funded in part by the cell phone industry, that found no cancer connection to cell phones, contrary to independently funded studies of the same issue.

The other critics in Kelland’s bacon story were Paulo Boffetta, a controversial ex-IARC scientist who wrote a paper defending asbestos while also receiving money to defend the asbestos industry in court; and Geoffrey Kabat, who once partnered with a tobacco industry-funded scientist to write a paper defending secondhand smoke.

Kabat also serves on the advisory board of the American Council on Science and Health (ACSH), a corporate front group. The day the Reuters story hit, ACSH posted a blog item (4/16/17) bragging that Kelland had used its advisor Kabat as a source to discredit IARC.

[See related post March 2019: Geoffrey Kabat’s Ties to Tobacco and Chemical Industry Groups] 

The industry connections of her sources, and their history of taking positions at odds with mainstream science, seems relevant, especially since the IARC bacon exposé was paired with a Kelland article about glyphosate that accused IARC advisor Chris Portier of bias because of his affiliation with an environmental group.

The conflict-of-interest framing served to discredit a letter, organized by Portier and signed by 94 scientists, that described “serious flaws” in a European Union risk assessment that exonerated glyphosate of cancer risk.

The Portier attack, and the good science/bad science theme, echoed through chemical industry PR channels on the same day the Kelland articles appeared.

IARC pushes back

In October 2016, in another exclusive scoop, Kelland portrayed IARC as a secretive organization that had asked its scientists to withhold documents pertaining to the glyphosate review. The article was based on correspondence provided to Kelland by a pro-industry law group.

In response, IARC took the unusual step of posting Kelland’s questions and the answers they had sent her, which provided context left out of the Reuters story.

IARC explained that Monsanto’s lawyers were asking scientists to turn over draft and deliberative documents, and in light of the ongoing lawsuits against Monsanto, “the scientists felt uncomfortable releasing these materials, and some felt that they were being intimidated.” The agency said they had faced similar pressure in the past to release draft documents to support legal actions involving asbestos and tobacco, and that there was an attempt to draw deliberative IARC documents into PCB litigation.

The story didn’t mention those examples, or the concerns about draft scientific documents ending up in lawsuits, but the piece was heavy on critiques of IARC, describing it as a group “at odds with scientists around the world,” which “has caused controversy” with cancer assessments that “can cause unnecessary health scares.”

IARC has “secret agendas” and its actions were “ridiculous,” according to a Monsanto executive quoted in the story.

IARC wrote in response (emphasis in original):

The article by Reuters follows a pattern of consistent but misleading reports about the IARC Monographs Programme in some sections of the media beginning after glyphosate was classified as probably carcinogenic to humans.

IARC also pushed back on Kelland’s reporting about Blair, noting the conflict of interest with her source Tarone and explaining that IARC’s cancer evaluation program does not consider unpublished data, and “does not base its evaluations on opinions presented in media reports,” but on the “systematic assembly and review of all publicly available and pertinent scientific studies, by independent experts, free from vested interests.”

PR agency narrative

The Science Media Centre—which Kelland has said has influenced her reporting—does have vested interests, and has also been criticized for pushing pro-industry science views. Current and past funders include Monsanto, Bayer, DuPont, Coca-Cola and food and chemical industry trade groups, as well as government agencies, foundations and universities.

By all accounts, SMC is influential in shaping how the media cover certain science stories, often getting its expert reaction quotes in media stories and driving coverage with its press briefings.

As Kelland explained in the SMC promotional video, “By the end of a briefing, you understand what the story is and why it’s important.”

That is the point of the SMC effort: to signal to reporters whether stories or studies merit attention, and how they should be framed.

Sometimes, SMC experts downplay risk and offer assurances to the public about controversial products or technologies; for example, researchers have criticized SMC’s media efforts on fracking, cell phone safety, Chronic Fatigue Syndrome and genetically engineered foods.

SMC campaigns sometimes feed into lobbying efforts. A 2013 Nature article (7/10/13) explained how SMC turned the tide on media coverage of animal/human hybrid embryos away from ethical concerns and toward their importance as a research tool—and thus stopped government regulations.

The media researcher hired by SMC to analyze the effectiveness of that campaign, Andy Williams of Cardiff University, came to see the SMC model as problematic, worrying that it stifled debate. Williams described SMC briefings as tightly managed events pushing persuasive narratives.

On the topic of glyphosate cancer risk, SMC offers a clear narrative in its press releases.

The IARC cancer classification, according to SMC experts, “failed to include critical data,” was based on “a rather selective review” and on evidence that “appears a bit thin” and “overall does not support such a high-level classification.” Monsanto and other industry groups promoted the quotes.

SMC experts had a much more favorable view of risk assessments conducted by the European Food Safety Authority (EFSA) and the European Chemicals Agency (ECHA), which cleared glyphosate of human cancer concerns.

EFSA’s conclusion was “more scientific, pragmatic and balanced” than IARC’s, and the ECHA report was objective, independent, comprehensive and “scientifically justified.”

Kelland’s reporting in Reuters echoes those pro-industry themes, and sometimes used the same experts, such as a November 2015 story about why European-based agencies gave contradictory advice about the cancer risk of glyphosate. Her story quoted two experts directly from an SMC release, then summarized their views:

In other words, IARC is tasked with highlighting anything that might in certain conditions, however rare, be able to cause cancer in people.  EFSA, on the other hand, is concerned with real life risks and whether, in the case of glyphosate, there is evidence to show that when used in normal conditions, the pesticide poses an unacceptable risk to human health or the environment.

Kelland included two brief reactions from environmentalists: Greenpeace called the EFSA review “whitewash,” and Jennifer Sass from the Natural Resources Defense Council said IARC’s review was “a much more robust, scientifically defensible and public process involving an international committee of non-industry experts.” (An NRDC statement on glyphosate put it this way: “IARC Got It Right, EFSA Got It From Monsanto.”)

Kelland’s story followed up the environmental group comments with “critics of IARC…say its hazard identification approach is becoming meaningless for consumers, who struggle to apply its advice to real life,” and ends with quotes from a scientist who “declares an interest as having acted as a consultant for Monsanto.”

When asked about the criticisms of pro-industry bias of the SMC, Fox responded:

We listen carefully to any criticism from the scientific community or news journalists working for UK media, but we do not receive criticism of pro-industry bias from these stakeholders. We reject the charge of pro-industry bias, and our work reflects the evidence and views of the 3,000 eminent scientific researchers on our database. As an independent press office focusing on some of the most controversial science stories, we fully expect criticism from groups outside mainstream science.

Expert conflicts

Scientific experts do not always disclose their conflicts of interest in news releases issued by SMC, nor in their high-profile roles as decision-makers about the cancer risk of chemicals like glyphosate.

Frequent SMC expert Alan Boobis, professor of biochemical pharmacology at Imperial College London, offers views in SMC releases on aspartame (“not a concern”), glyphosate in urine (no concern), insecticides and birth defects (“premature to draw conclusions”), alcohol, GMO corn, trace metals, lab rodent diets and more.

The ECHA decision that glyphosate is not a carcinogen “is to be congratulated,” according to Boobis, and the IARC decision that it is probably carcinogenic “is not a cause for undue alarm,” because it did not take into account how pesticides are used in the real world.

Boobis declared no conflicts of interest in the IARC release or any of the earlier SMC releases that carry his quotes. But he then sparked a conflict-of-interest scandal when news broke that he held leadership positions with the International Life Sciences Institute (ILSI), a pro-industry group, at the same time he co-chaired a UN panel that found glyphosate unlikely to pose a cancer risk through diet. (Boobis is currently chair of the ILSI Board of Trustees, and vice president ad interim of ILSI/Europe.)

ILSI has received six-figure donations from Monsanto and CropLife International, the pesticide trade association. Professor Angelo Moretto, who co-chaired the UN panel on glyphosate along with Boobis, also held a leadership role in ILSI. Yet the panel declared no conflicts of interest.

Kelland did not report on those conflicts, though she did write about the findings of the “UN experts” who exonerated glyphosate of cancer risk, and she once recycled a Boobis quote from an SMC press release for an article about tainted Irish pork. (The risk to consumers was low.)

When asked about the SMC conflict of interest disclosure policy, and why Boobis’ ISLI connection was not disclosed in SMC releases, Fox responded:

We ask all researchers we use to provide their COIs and proactively make those available to journalists. In line with several other COI policies, we are unable to investigate every COI, though we welcome journalists doing so.

Boobis could not be reached for comment, but told the Guardian, “My role in ILSI (and two of its branches) is as a public sector member and chair of their boards of trustees, positions which are not remunerated.”

But the conflict “sparked furious condemnation from green MEPs and NGOs,” the Guardian reported, “intensified by the [UN panel] report’s release two days before an EU relicensing vote on glyphosate, which will be worth billions of dollars to industry.”

And so goes it with the tangled web of influence involving corporations, science experts, media coverage and the high-stakes debate about glyphosate, now playing out on the world stage as Monsanto faces lawsuits over the chemical due to cancer claims, and seeks to complete a $66 billion deal with Bayer.

Meanwhile, in the US, as Bloomberg reported on July 13: “Does the World’s Top Weed Killer Cause Cancer? Trump’s EPA Will Decide.”

Messages to Reuters may be sent through this website (or via Twitter: @Reuters). Please remember that respectful communication is the most effective.

How Monsanto Manufactured ‘Outrage’ at IARC over Cancer Classification

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Posted on by Stacy Malkan
By Carey Gillam

Three years ago this month Monsanto executives realized they had a big problem on their hands.

It was September 2014 and the company’s top-selling chemical, the weed killer called glyphosate that is the foundation for Monsanto’s branded Roundup products, had been selected as one among a handful of pesticides to undergo scrutiny by the World Health Organization’s International Agency for Research on Cancer (IARC). Monsanto had spent decades fending off concerns about the safety of glyphosate and decrying scientific research indicating the chemical might cause cancer or other diseases. And even though the IARC review was still months away, Monsanto’s own scientists knew what the outcome would likely be—and they knew it wouldn’t be good.

Internal company records show not just the level of fear Monsanto had over the impending review, but notably that company officials fully expected IARC scientists would find at least some cancer connections to glyphosate. Company scientists discussed the “vulnerability” that surrounded their efforts to defend glyphosate amid multiple unfavorable research findings in studies of people and animals exposed to the weed killer. In addition to epidemiology studies, “we also have potential vulnerabilities in the other areas that IARC will consider, namely, exposure, genetox and mode of action…” a Monsanto scientist wrote in October 2014. That same email discussed a need to find allies and arrange funding for a “fight”—all months before the IARC meeting in March 2015.

And Monsanto predicted internally before IARC even met that the review of the scientific evidence would result in a decision that glyphosate “possibly” was carcinogenic or “probably” was. Monsanto officials had forecast the IARC decision in an internal “preparedness” plan that warned colleagues to “assume and prepare for the outcome…” The document shows Monsanto thought it most likely that IARC would peg glyphosate as a “possible human carcinogen.” The rating of probable carcinogen was “possible but less likely,” the Monsanto memo stated. IARC ultimately did classify glyphosate as “probably carcinogenic to humans.”

As the IARC meeting loomed, the internal documents show that Monsanto did not wait for the actual IARC decision before acting. It enlisted teams of PR and lobbying experts, scientists and others in a plan aimed at creating what was designed to appear as a storm of “outcry” and “outrage” to follow the IARC classification. IARC had a history of “questionable and politically charged rulings,” the Monsanto memo said.

The plan was to create enough controversy to thoroughly discredit IARC’s evaluation because Monsanto officials knew that regulators would be influenced by IARC, and continued widespread use of the top-selling chemical could be at risk.

“It is possible that IARC’s decision will impact future regulatory decision making,” Monsanto stated in its internal correspondence.

The timing was critical because in 2015 both the U.S. Environmental Protection Agency (EPA) and the European Commission were evaluating re-authorizations of Monsanto’s weed killer. Following IARC’s classification, both the European Union and the EPA delayed final decisions on glyphosate amid the still-brewing debate over the chemical’s safety.

“What this indicates to me is that it was obvious to Monsanto that there was evidence of carcinogenicity,” said Peter Infante, an epidemiologist who worked for more than 24 years for the U.S. government studying cancer risks to workers from exposure to toxic substances. “It would seem to me that Monsanto does not like the public to be informed of the cancer hazard.”

“What this indicates to me is that it was obvious to Monsanto that there was evidence of carcinogenicity.”

After the IARC ruling, a storm of protest did erupt from various individuals and organizations alongside Monsanto’s howls of indignant outrage. Some have questioned the wisdom of U.S. funding for IARC and Monsanto has perpetuated a false narrative that the chairman of the IARC working group withheld critical information from the team.

The document trail, which includes internal emails, memos and other communications obtained from Monsanto by plaintiffs’ attorneys through litigation pending in the U.S., makes clear that the debate over, and challenge to, IARC’s classification did not sprout authentically from a variety of voices, but rather was manufactured by Monsanto in advance of IARC’s decision and continued afterward. The goal was—and is—to convince regulators to discount the findings of the team of independent scientific experts who made up the IARC team that examined glyphosate.

The internal records obtained through litigation, combined with documents obtained through Freedom of Information Act (FOIA) and state records requests also show that the actions employed to discredit IARC were part of a decades-long pattern of deceptive tactics by Monsanto to persuade regulators, lawmakers and members of the press and public that glyphosate and Roundup are safe. The company has used these tactics multiple times over the years to try to discredit several scientists whose research has found harmful effects associated with glyphosate.

“Orchestrate Outcry”

The IARC attack plan, which was laid out in a February 2015 memo, involved not only Monsanto’s internal PR people, scientists and marketing experts, but a range of outside industry players. Various individuals were assigned tasks. The “strategies and tactics” included:

  • “Orchestrate Outcry” with IARC Decision—Industry conducts robust media/social media outreach on process and outcome.
  • “Identify/request third-party experts to blog, op/ed, tweet and/or link, repost, retweet, etc.” The documents show one such “expert,” academic Henry Miller, was provided a draft article to submit to Forbes for publication under his name with no mention of Monsanto’s involvement. Forbes learned of the deceit last month and severed relations with Miller.
  • “Inform/Inoculate/Engage Industry Partners”—Notably the industry partners listed included three organizations that purport to be independent of Monsanto but have long been seen by critics as front groups for the company—Monsanto named Academics Review and the Genetic Literacy Project, both based in the U.S. and Sense About Science, which has run operations in the United Kingdom and the U.S., as groups to help with its mission. In fact, Sense About Science was the group identified by Monsanto to lead the industry response and “provide a platform for IARC observers.” The groups did as Monsanto planned, posting scathing attacks on IARC on their websites.
  • Engagement with Regulatory Agencies—Monsanto planned for grower associations/ growers to “write regulators with an appeal that they remain focused on the science, not the politically charged decision by IARC.”
  • “Push opinion leader letter to key daily newspaper on day of IARC ruling” with assistance of the Potomac Group marketing firm.

The preparedness plan also called for supporting “the development of three new papers on glyphosate focused on epidemiology and toxicology.” As planned, shortly after the IARC decision Monsanto arranged for several scientists—many of them former employees or paid consultants—to author and publish research papers supporting glyphosate safety. It was revealed through discovery documents that Monsanto discussed ghostwriting the papers. In one email, company scientist William Heydens told colleagues the company could “ghost-write” certain reports that would carry the names of outside scientists—”they would just edit & sign their names so to speak,” he wrote. He cited as an example a 2000 study that has been regarded as influential by regulators. Documents show Monsanto’s heavy writing and editing involvement in the resulting purportedly “independent” review.

Monsanto has adamantly denied ghostwriting, but one memo from August 2015 from the files of Monsanto scientist David Saltmiras actually uses that term, stating that he “ghostwrote cancer review paper Greim et al (2015)…” referring to a paper that showed authorship by German scientist Helmut Greim along with Saltmiras. (Monsanto has acknowledged that Greim worked as a consultant to the company with part of his job being to publish peer-reviewed data on glyphosate).

Another internal email illustrates the writing by a Monsanto scientist of a research paper titled “Developmental and Reproductive Outcomes… after Glyphosate Exposure.” The scientist, Donna Farmer, did extensive work, including what she called a “cut and paste” of certain information. But her name was not included as an author before the paper was submitted to a journal. The published version concluded there was “no solid evidence linking glyphosate exposure to adverse developmental or reproductive effects.”

The paper trail of documents also show that Monsanto feared that a U.S. health agency planning to review glyphosate in 2015 might agree with IARC and collaborated with the EPA to successfully block that agency—the Agency for Toxic Substances & Disease Registry (ATSDR)—from doing its review. “We’re trying to do everything we can to keep from having a domestic IARC occur,” a company official wrote. 

The record also shows that well before IARC, Monsanto recruited networks of academic scientists in the U.S and Europe who have defended Monsanto’s products, including its weed killer, without declaring their collaborations with Monsanto. And that these silent soldiers helped Monsanto discredit scientists who reported research showing harm associated with glyphosate and Roundup, including working at Monsanto’s bidding to get one damaging study by French scientist Gilles-Éric Séralini retracted from a scientific journal where it was published in September 2012. The company even discounted concerns by one of its own paid consultants who found evidence of glyphosate’s genotoxicity and refused to do the additional tests he recommended.

If what Monsanto says is true, that glyphosate is so very safe, and that there is no evidence it causes cancer or other health problems, then why all the smoke and mirrors? Why would the company need to ghostwrite research papers to present to regulators? Why would Monsanto need to establish networks of scientists to promote glyphosate safety and to tear down scientists whose research raises concerns? Why would Monsanto try to block a review of glyphosate by the U.S. ATSDR?

Two committees of the European Parliament have scheduled a hearing for Oct. 11 in Brussels to delve into these and other questions as the European Commission faces a looming deadline for making a decision on the re-authorization of glyphosate before the end of 2017.

Lawmakers should take note of evidence that their own food safety agency appears to have dropped the ball on independent assessments of glyphosate research. Records show that the European Food Safety Authority (EFSA) dismissed a study linking Monsanto’s weed killer to cancer at the advice of an EPA official who Monsanto deemed “useful” and who is part of a probe now into possible collusion between the EPA and Monsanto.

They should also pay heed to news that EFSA based its recommendation on glyphosate on a report that copied and pasted analyses from a Monsanto study.

Monsanto Chairman Hugh Grant was invited to address the Parliament meeting in October, but declined to appear or to send anyone else from Monsanto. Dr. Roland Solecki, head of chemical safety for the German Federal Institute for Risk Assessment (BfR), has also declined, according to organizers. I do plan to participate, as will a representative from IARC and several others.

Throughout this debate, it is worthwhile to remember that the concerns about glyphosate safety have deep roots that date all the way back to at least 1985 when EPA toxicologists looked at data showing rare tumors in mice dosed with glyphosate and determined that glyphosate was “possibly carcinogenic to humans.”

Monsanto protests eventually reversed that classification but in light of all of the deceptive tactics recently revealed in documents, the words of an EPA scientist more than 30 years ago are worth considering today: “Glyphosate is suspect… Monsanto’s argument is unacceptable.”

The EPA scientist in that 1985 memo also wrote: “Our viewpoint is one of protecting the public health when we see suspicious data. It is not our job to protect registrants…”

European lawmakers would be wise to recall those words.

This article was originally published in EcoWatch.

Carey Gillam is a veteran reporter and author of Whitewash – The Story of a Weed Killer, Cancer and the Corruption of Science. She is research director for U.S. Right to Know, a nonprofit consumer watchdog group working for truth and transparency in our food system.  

Reuters’ Kate Kelland promoted false narrative about IARC and Aaron Blair

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Posted on by Stacy Malkan

UPDATE January 2019: Documents filed in court show that Monsanto provided Kate Kelland with the documents for her June 2017 story about Aaron Blair and gave her a slide deck of talking points the company wanted covered. For more details, see Carey Gillam’s Roundup Trial Tracker post.

The following analysis was prepared by Carey Gillam and posted June 28, 2017:

A June 14, 2017 Reuters article authored by Kate Kelland, headlined “The WHO’s cancer agency left in the dark over glyphosate evidence,” wrongly accused a cancer scientist of withholding important data in the safety assessment of glyphosate conducted by the International Agency for Research on Cancer (IARC).

Kelland’s story contains factual errors and states conclusions that are contradicted by a full reading of the documents she cited as primary sources. It is notable that Kelland provided no link to the documents she cited, making it impossible for readers to see for themselves how far she veered from accuracy in interpreting them. The primary source document clearly contradicts the premise of Kelland’s story. Additional documents her story referenced, but also did not link to, can be found at the end of this post.

Background: The Reuters story was one in a series of critical pieces the news agency has published about IARC that Kelland wrote after IARC classified glyphosate as a probable human carcinogen in March 2015. Glyphosate is a highly profitable chemical herbicide used as the main ingredient in Monsanto’s Roundup weed killing products, as well as hundreds of other products sold around the world. The IARC classification triggered mass litigation in the United States brought by people alleging their cancers were caused by Roundup, and prompted the European Union and U.S. regulators to deepen their evaluation of the chemical. In response to the IARC classification, and as a means of defending itself against the litigation and shoring up regulatory support, Monsanto has lodged multiple complaints against IARC seeking to undermine IARC’s credibility. The June 14 Kelland story, which quoted a top Monsanto “strategy” executive, furthered those strategic efforts and has been touted by Monsanto and others in the chemical industry as proof that the IARC classification was flawed.

Consider:

  • A deposition of scientist Aaron Blair, a draft abstract and email communication Kelland references in her story as “court documents” were not in fact court documents but were documents created and obtained as part of discovery in the multidistrict litigation brought by the cancer victims who are suing Monsanto. The documents were held in the possession of Monsanto’s legal team as well as plaintiffs’ legal team. See docket U.S. District Court for the Northern District of California, lead case 3:16-md-02741-VC. If Monsanto or a surrogate provided the documents to Kelland, such sourcing should have been cited. Given that the documents were not obtained through the court, as Kelland’s story implies, it seems apparent Monsanto or surrogates planted the storyline and provided Kelland with the documents, or at least selected parts of the documents, along with its assessment of them.
  • Kelland’s article provides commentary and an interpretation of the deposition from Bob Tarone, whom Kelland describes as “independent of Monsanto.” Yet information provided by IARC establishes that Tarone has acted as a paid consultant to Monsanto on its efforts to discredit IARC.
  • Reuters teased the story with this statement: “The scientist leading that review knew of fresh data showing no cancer link – but he never mentioned it and the agency did not take it into account.” Kelland implied that Dr. Blair was intentionally hiding critical information. Yet the deposition shows that Blair testified that the data in question was “not ready” to submit to a journal for publication and would not be allowed for consideration by IARC because it had not been finished and published. Much of the data was gathered as part of a broad U.S. Agricultural Health Study and would have been added onto several years of previously published information from the AHS that showed no association between glyphosate and non-Hodgkin lymphoma. A Monsanto lawyer questioned Blair about why the data wasn’t published in time to be considered by IARC, saying: “You decided, for whatever reason, that that data was not going to be published at that time, and therefore was not considered by IARC, correct?” Blair replied: “No. Again you foul up the process.” “What we decided was the work that we were doing on these different studies were not yet — were not yet ready to submit to journals.  Even after you decide to submit them to journals for review, you don’t decide when it gets published.” (Blair deposition transcript page 259) Blair also said to the Monsanto attorney: “What is irresponsible is to rush something out that’s not fully analyzed or thought out” (page 204).
  • Blair also testified that some data from the unfinished, unpublished AHS was “not statistically significant” (page 173 of deposition). Blair also testified in that deposition about data showing strong connections between glyphosate and NHL that also was not disclosed to IARC because it was not published.
  • Blair testified that some data from a North American Pooled Project study showed a very strong association with NHL and glyphosate, with a doubling and tripling of risk associated with the pesticide seen in people who used glyphosate more than twice a year. Just as the AHS data, this data was also not published or given to IARC (pages 274-283 of Blair deposition).
  • Kelland’s article also states: “Blair also said the data would have altered IARC’s analysis. He said it would have made it less likely that glyphosate would meet the agency’s criteria for being classed as ‘probably carcinogenic.’”  That testimony (on pages 177-189 of deposition) does not support those statements at all.  Blair ultimately says “probably” to questioning from Monsanto’s attorney asking if the 2013 AHS data had been included in a meta-analysis of epidemiology data considered by IARC, if that “would have lowered the meta-relative risk for glyphosate and non-Hodgkin lymphoma even further…” Kelland’s story also leaves the impression that this unpublished epidemiology data from an unfinished study would have been a game-changer for IARC. In fact, reading the deposition in full, and comparing it to IARC’s report on glyphosate, underscores how false and misleading that notion is.  Blair testified only to epidemiology data and IARC had already deemed the epidemiology evidence that it did see as “limited.” Its classification of glyphosate saw significance in the animal (toxicology) data it reviewed, deeming it “sufficient.”
  • Kelland ignores important portions of the Blair deposition specific to a published 2003 study that found “there was over a doubling of the risk of non-Hodgkin’s lymphoma for people who had been exposed to glyphosate” (pages 54-55 of the deposition).
  • Kelland ignores testimony in the Blair deposition regarding a “300 percent increased risk” for cancer in Swedish research (page 60 of deposition).
  • Reading through the entire deposition shows that Blair testified as to many examples of studies showing a positive association between glyphosate and cancer, all of which Kelland ignored.
  • Kelland writes that in his legal testimony, Blair also described the AHS as “powerful” and agreed the data showed no link to cancer. She implied he was speaking of the specific unpublished 2013 data on NHL and glyphosate that is a tiny subset of information obtained from the AHS, when in fact the testimony shows he was speaking of the larger AHS umbrella of work, which has been tracking farm families and collecting data on dozens of pesticides for several years. What Blair actually said of the broad AHS was this: “ “It’s — it’s a powerful study. And it has advantages. I’m not sure I would say it is the most powerful, but it is a powerful study.” (page 286 of deposition)
    • Furthermore, when speaking directly of the 2013 AHS data on glyphosate and NHL, Blair confirmed that the unpublished data needed “cautious interpretation” given the number of exposed cases in subgroups was “relatively small” (page 289).
  • Kelland states “IARC told Reuters that, despite the existence of fresh data about glyphosate, it was sticking with its findings,” suggesting a cavalier attitude. Such a statement is entirely misleading. What IARC in fact said was its practice is not to consider unpublished findings and that it can re-evaluate substances when a significant body of new data is published in literature.

Related coverage:

Related Documents

Videotaped deposition of Aaron Earl Blair, Ph.D., March 20, 2017

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What Killed Jack McCall? A Farmer Dies; A Case Against Monsanto Takes Root

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Posted on by Stacy Malkan

By Carey Gillam

CAMBRIA, Calif.- Standing on the ridge overlooking her central California farm, new widow Teri McCall sees her husband Jack nearly everywhere. There, atop the highest hill, is where the couple married in 1975- two self-described “hippies’ who knew more about how to surf than farm. And over there, surrounded by the lemon, avocado and orange trees Jjack mccall copyack planted, sits the 800-square-foot house the young Vietnam veteran built for his bride and a family that grew to include two sons and a daughter. Solar panels Jack set up in a sun-drenched stretch of grass power the farm’s irrigation system.

And down there, clasped in the cusp of the velvet green valley sits the century-old farmhouse Jack and Teri eventually made their permanent home. Jack installed a stained glass window featuring a heart and flowers over the front door.

“Literally hundreds of times a day, something reminds me of him,” McCall says, as she and a visitor strolled through the orchards on a recent sunny spring morning. “That’s part of why it’s so hard to believe… I can never see him again.”

Anthony ‘Jack’ McCall, 69, died Dec. 26 after a painful and perplexing battle with non-Hodgkin lymphoma. The loss is certain, fixed forever into his family’s heartbreak. But questions about why and how he was stricken – a man who never smoked, stayed fit and had no history of cancer in his family – are part of what some legal experts see as a potential landmark legal claim against one of the world’s largest agrichemical companies, Monsanto Co.

McCall shunned pesticide use on his farm, except for the herbicide called Roundup – marketed by Monsanto as having extremely low toxicity. He used Roundup regularly, spraying it himself around the farm to drive back worrisome weeds. He even recommended Roundup to friends, telling them it was supposed to be much safer than alternatives on the market, and touting its effectiveness.

But now in his death, McCall is one of several plaintiffs in more than a dozen lawsuits that claim the active ingredient in Roundup – a chemical called glyphosate – gave them cancer, and that Monsanto has long known glyphosate poses “significant risks to human health, including a risk of causing cancer.”

The lawsuits, brought by plaintiffs in California, Florida, Missouri, Delaware, Hawaii,and elsewhere over the last several months, claim Monsanto has hidden evidence, and manipulated regulators and the public into believing in the safety of glyphosate, which annually brings in about $5 billion, or a third of total sales, for the agribusiness giant. Like McCall, many farmed, or worked in agricultural jobs in which they regularly were using or exposed to glyphosate.

The claims come at a critical time for Monsanto and its signature product as regulators in the United States and other countries evaluate whether or not to continue to allow glyphosate herbicides. Last year the World Health Organization’s cancer experts classified glyphosate as a probable human carcinogen. That team, the International Agency for Research on Cancer (IARC), said glyphosate shows a “positive association” for non-Hodgkin lymphoma. 

The outcomes of the legal battle and the regulatory reviews could have broad implications. Glyphosate is the most widely used herbicide on the planet, sprayed on fields for row crops like corn, soybeans and wheat, as well as a variety of fruits, nuts and vegetable crops such as almonds, apples, cherries and oranges.

That ubiquitous role played by glyphosate means the litigation, plaintiffs’ lawyers say, marks the beginning of a potential wave of legal actions against Monsanto. Teams of attorneys have been criss-crossing the country lining up potential plaintiffs who they say will likely number in the hundreds and possibly thousands. It’s a time-tested practice by plaintiffs’ attorneys who have brought similar mass actions in the past against tobacco, pharmaceutical and chemical industries.

“Monsanto has deliberately concealed or suppressed information about the dangers of its product,” said environmental and chemical pollution attorney Robert F. Kennedy Jr., who is assisting in litigating glyphosate cases. “This is big. It’s on every farm in the world.”

Kennedy predicts glyphosate liability litigation will become as widespread as has been decades of litigation over asbestos, which is seen in legal circles as the longest-running mass tort action in U.S. history. Asbestos was used for years as a safe and effective flame retardant in the construction industry but has been tied to lung diseases and cancers, and spawned hundreds of millions of dollars in legal claims.

The glyphosate litigation partly mirrors courtroom battles Monsanto has been fighting for years involving the polychlorinated biphenyls, or PCBs it once manufactured. Plaintiffs in those cases also claim PCBs caused them to fall ill while Monsanto hid the risks. Monsanto claims plaintiffs cannot definitively link illnesses to PCB exposure.

AMONG THE SAFEST OPTIONS
Patented by Monsanto and commercialized in 1974, glyphosate herbicide has long been considered among the safest pesticide options on the market. The weed-killer came off patent in 2000 and is now used in more than 700 products around the world, beloved by farmers, homeowners, and groundskeepers. The chemical is the world’s most widely used herbicide with an estimated 1.8 billion pounds applied in 2014, up 12-fold from 1994, according to recently published research.

But as use has grown, concerns about safety have also mounted. Residues have been documented by public and private researchers in waterways, air, food and in human bodily fluids. Several scientific studies tied the chemical to cancers and other health problems before the March 2015 classification by IARC.

Lawyers for plaintiffs in the glyphosate cases say that among the evidence that glyphosate’s toxicity has long been known is an EPA memo detailing how glyphosate was classified by agency scientists as a possible human carcinogen in 1985 before classified in 1991 as a having “evidence of non-carcinogenicity” for humans. The classification was changed despite the fact that some peer review members did not concur. The lawsuits also cite evidence of fraud at laboratories used by Monsanto to perform toxicology studies of glyphosate, and point to fraud convictions of executives at those labs.

St. Louis-based Monsanto, a global agrichemical and seed powerhouse, cites its own evidence to counter both the validity of the allegations in the lawsuits, as well as the IARC findings. Last year, the company hired a team of experts to review the safety of glyphosate, and said that team found no cancer links. 

“Comprehensive long-term toxicological studies repeated over the last 30 years have time and again demonstrated that glyphosate is unlikely to pose a cancer risk in humans,” Monsanto states on its website. ‘Regulatory authorities and independent experts around the world have reviewed numerous long-term/carcinogenicity and genotoxicity studies and agree that there is no evidence that glyphosate… causes cancer, even at very high doses.”

Monsanto attorneys have been seeking to dismiss and/or delay several cases thus far filed, asserting that federal law and approvals by the Environmental Protection Agency for labels on Roundup herbicide products protect Monsanto from the claims in the lawsuits. In recent arguments in U.S. District Court in Northern California, for example, lawyers for Monsanto argued that “EPA repeatedly has concluded that glyphosate is not a carcinogen.” But in April a federal judge in California ruled that Monsanto was not protected from liability by the EPA registration and approved labels.

In a Missouri case that Monsanto also was unable to get dismissed, discovery is starting, and plaintiffs’ lawyers are eagerly awaiting what they hope will be a treasure trove of evidence for their clients.

The legal claims come at the same time that European and U.S. regulators are conducting their own assessments of the safety of glyphosate and considering restrictions, processes that have become fraught with infighting and accusations of bias from both fans and foes of glyphosate. The European Food Safety Authority (EFSA) said in November that evidence shows glyphosate is unlikely to be carcinogenic. But the European Parliament has said the herbicide use should be reined in with a ban on non-professional use and around parks and playgrounds because of the health worries.

The EPA was due to release a fresh risk assessment on glyphosate nearly a year ago, but has stalled the process amid the uproar. And in an odd twist to the saga, on April 29, the agency posted an internal document to its website, showing that the EPA’s cancer assessment experts have determined that glyphosate is “Not Likely to be Carcinogenic to Humans.”

On May 2, EPA withdrew the memo from its website and said it was not supposed to have been released because the cancer assessment is ongoing. But Monsanto heralded the release of the document as proof of what it has been saying about glyphosate’s safety.

Wall Street is keeping a wary eye on the litigation. But generally market watchers care less about Monsanto’s risk from potential liability payouts and more about any potential long-term revenue hit if regulators were to restrict or ban glyphosate, said Piper Jaffray analyst Brett Wong, who tracks Monsanto’s business strategies and financial health. The courtroom battles could influence regulators, he said.

“There are obviously a lot of lawsuits,” Wong said. “They aren’t intrinsic to impacting their business but there is always some sentiment pressure on investors. If it were to impact the regulatory structure and glyphosate was banned… that could obviously have an impact.”

Legal experts with experience defending the chemical industry are watching the cases with interest, and many say given a lack of regulatory support for the cancer linkage, plaintiffs’ attorneys have an uphill climb to make such claims stick.

“The evidence to support the claims isn’t there, said one prominent lawyer, declining to be quoted by name. “It’s not mothers’ milk by any means. I wouldn’t mix it in my drink, but it’s one of the safest chemicals out there,” he said.

Attorney Brent Wisner, who is representing the McCall family, said he is confident in the strength of the evidence against Monsanto. “It’s going to be a fairly large litigation when it’s all said and done. We’re confident we’ll be able to show that Monsanto controlled research and suppressed science,” he said.

Back in Cambria, Jack McCall’s son Paul McCall is running the farm in his father’s place. His eyes tear quickly when asked about his father’s diagnosis in September 2015 and death only three months later, the day after Christmas. He doesn’t want to talk about the lawsuit, other than to say he has no use for glyphosate now, and wants to warn others away from it.

“This is a battle that has to be fought,” he said.

How big and how bloody the litigation becomes is still an open question. The shouting from both sides of the issues is getting louder with each passing day. But the deep questions about the safety of this herbicide deserve serious and scientific review as the answers hold implications for our food production, our environment and the health of our families well into the future.

This article originally appeared in Huffington Post. 

Carey Gillam is a veteran former Reuters journalist, current freelance writer/editor and research director for U.S. Right to Know, a food industry research group