coronavirus

FOI documents on origins of Covid-19, gain-of-function research and biolabs

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Posted on by Gary Ruskin

In July 2020, U.S. Right to Know began submitting public records requests in pursuit of data from public institutions in an effort to discover what is known about the origins of the novel coronavirus SARS-CoV-2, which causes the disease Covid-19. We are also researching accidents, leaks and other mishaps at laboratories where pathogens of pandemic potential are stored and modified, and the risks of gain-of-function research, which involve experiments on such pathogens to increase their host range, infectivity, transmissibility or pathogenicity.

For more information about our investigation, see our biohazards page. You can read our reporting here on the documents we have obtained so far from Freedom of Information requests. The documents are posted below in chronological order in which we received them.

University of Texas Medical Branch

Vineet Menachery/Pei-Yong Shi/UTMB batch #2 (5.4.22) (5070 pages)
LeDuc/UTMB batch #1 (4.27.22) (4578 pages)
UTMB-Wuhan Institute of Virology memorandum of understanding (4.20.22) (9 pages)

See our reporting: Wuhan lab can delete data in ‘explosive’ legal agreement with U.S. lab. (4.20.22)

U.S. State Department records

State Department batch #13 (4.26.22) (16 pages)
State Department batch #12 (3.28.22) (45 pages)

See our reporting: Lab accident is ‘most likely but least probed’ COVID origin, State Dept. memo says (3.28.22)

State Department batch #11 (2.24.22) (52 pages)
State Department batch #10 (1.25.22) (47 pages)
State Department batch #9 (12.27.21) (20 pages)
State Department batch #8 (12.7.21) (16 pages)
State Department batch #7 (10.28.21) (37 pages)
State Department batch #6 (9.27.21) (100 pages)
State Department batch #5 (7.26.21) (56 pages)

  • January 2018 cable on the Wuhan Institute of Virology’s BSL-4 laboratory (a more complete version of the cable first reported by Josh Rogin in the Washington Post)

State Department batch #4 (6.24.21) (129 pages)
State Department batch #3 (5.24.21) (114 pages)
State Department batch #2 (4.26.21) (37 pages)
State Department batch #1 (3.24.21) (92 pages)

U.S. Centers for Disease Control and Prevention records

CDC batch #4 (4.13.22) (1,864 pages)
CDC batch #3 (4.13.22) (1,864 pages)

See our reporting: Emails raise questions about China’s sway over first WHO mission on COVID-19.

CDC batch #2 (6.28.21) (1,302 pages)
CDC batch #1 (3.05.21) (1,063 pages)

U.S. Health and Human Services (HHS) records

HHS batch #4 (4.8.22) (248 pages)
HHS batch #3 (4.8.22) (325 pages)
HHS batch #2 (1.26.22) (321 pages)
HHS batch #1 (12.30.21) (266 pages)

U.S. Agency for International Development (USAID) records

USAID batch #2 (4.7.22) (357 pages)
USAID batch #1 (3.17.22) (42 pages)

National Institutes of Health (NIH) records

NIH batch #2 (3.3.22) (308 pages)
NIH batch #1 (2.1.22) (322 pages)

Defense Threat Reduction Agency (DTRA) grant documents

DTRA batch #2 (2.23.22) (311 pages)

Records obtained from a FOIA request to DTRA, containing DTRA grants and awards to the EcoHealth Alliance, for projects such as: biosurveillance for zoonotic spillover of viruses in rural communities in India; reducing the threat of MERS coronavirus and avian influenza; predicting biothreat impacts from early stage data via transfer learning, and more.

DTRA batch #1 (2.22.22) (2790 pages)

Records obtained from a Freedom of Information Act request to the Defense Threat Reduction Agency, containing DTRA grants and awards to the EcoHealth Alliance, for projects such as: developing a rapid identification tool for undisclosed emerging infectious disease events, understanding Rift Valley fever in South Africa, serological biosurveillance for spillover of henipaviruses and filoviruses in Malaysia and India, and others.

UC Davis/Jonna Mazet emails and documents

Documents obtained through a California Public Records Act request for records of UC Davis Vice Provost Jonna Mazet. Dr. Mazet was the principal investigator on the U.S. Agency for International Development’s (USAID) Emerging Pandemic Threat (EPT) Program PREDICT-1 and PREDICT-2 grants with the EcoHealth Alliance.

Batch #4 (1.10.22) (261 pages)
Batch #3 (12.7.21) (137 pages)
Batch #2 (12.7.21) (541 pages)
Batch #1 (10.27.21)(139 pages)

U.S. Food and Drug Administration (FDA) records

Records obtained through a Freedom of Information Act request to the U.S. Food and Drug Administration (FDA) for Center for Biologics Evaluation and Research (CBER) communications with or about the Wuhan Institute of Virology and other Wuhan-based research institutes; EcoHealth Alliance; China; and the Global Health Security Agenda. Records include proposed SARS-CoV-2 human challenge studies (not clinical trials) to evaluate COVID-19 vaccine efficacy, associated with the published World Health Organization nCoV Research & Development Blueprint. Draft informed consent and study protocols as well as descriptions of biocontainment units and SARS-CoV-2 challenge strains are included.

Batch #1 (12.10.21)(262 pages)

Xiang-Dong Fu emails

Documents obtained through a California Public Records Act request for records of Professor Xiang-Dong Fu, Distinguished Professor of Cellular and Molecular Medicine, University of California- San Diego. Dr. Fu has been a member of the International Executive Committee of Performance Evaluation of the Wuhan Institute of Virology.

Batch #1 (11.12.21) (641 pages)

See our reporting:

Latinne et al. (2020) and the National Center for Biotechnology Information (NCBI)

NCBI emails (10.12.21): File #1, File #2, File #3, File #4, File #5, File #6, File #7, File #8. Emails between NCBI and scientists from Ecohealth Alliance and Wuhan Institute of Virology regarding the submission of genetic sequence information about bat betacoronavirus isolate 7896, which is very closely related to RaTG13.

National Science Advisory Board for Biosecurity (NSABB)

NSABB emails (10.11.21) (104 pages). Emails between Mary Ellen Groesch, NSABB members, and NIH staff regarding the replacement of 11 NSABB members, and 2014 plans to discuss dual use research guidelines (DURC) and a new biosecurity and biosafety program.

Documents obtained through FOIA to the NIH for email correspondence of Dr. Mary Ellen Groesch, Office of the Director, National Heart Lung and Blood Institute (NHLBI) and former executive director of the National Science Advisory Board for Biosecurity (NSABB).

Shan-Lu Liu emails

Zhengli Shi’s edits to a widely-cited EM&I commentary titled “No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2.” (9.27.21) (10 pages). Document obtained through an Ohio Public Records Act request for a missing attachment from the email records of Ohio State University Professor Shan-Lu Liu.

Shan-Lu Liu emails: Ohio State University (8.4.21) (488 pages). Documents obtained through an Ohio Public Records Act request for the email records of Shan-Lu Liu, Professor, College of Veterinary Medicine, The Ohio State University.

See our reporting:

CSIRO emails

CSIRO emails: Australian Commonwealth Scientific and Industrial Research Organization (CSIRO) Records. Documents obtained through an Australian Freedom of Information Act request to CSIRO for email records between Gary Crameri, Researcher, Health and Biosecurity Business Unit, Australian Center for Disease Preparedness (ACDP) of CSIRO, and collaborators, including Drs. Lin-Fa Wang and Edward C. Holmes.

CSIRO Batch #5 (8.31.21) (63 pages)
CSIRO Batch #4 (8.31.21) (99 pages)
CSIRO Batch #3 (8.31.21) (50 pages)
CSIRO Batch #2 (8.31.21) (4 pages)
CSIRO Batch #1 (8.31.21) (154 pages)

Fang Li emails

Fang Li emails: (6.25.21) (1234 pages). Documents obtained from public records requests for emails of Fang Li, PhD, Professor, Department of Veterinary and Biomedical Sciences, University of Minnesota.

Linda Saif emails

Linda Saif emails batch #1: (4.7.21) (303 pages). Documents obtained from public records requests for emails of Linda Saif, PhD, Distinguished University Professor, Department of Veterinary Preventative Medicine, Center for Food Animal Health, Ohio Agricultural Research and Development Center, Ohio State University.

See our reporting: Chinese-linked journal editor sought help to rebut Covid-19 lab origin hypothesis (5.24.21)

Ralph Baric emails

Ralph Baric emails batch #4: (12.30.21) (24 pages) Documents made available through a North Carolina public records law request for communications of Professor Ralph Baric related to biodefense and the Defense Advanced Research Projects Agency (DARPA).

Ralph Baric emails batch #3: (2.25.21) (22,736 pages) Documents obtained from public records requests for emails Ralph Baric, PhD, William R. Kenan, Jr. Distinguished Professor in the Department of  Epidemiology and Professor in the Department of Microbiology and Immunology at University of North Carolina, Chapel Hill.
Ralph Baric emails batch #2: (2.17.21) (332 pages).

See our reporting:

Ralph Baric emails batch #1 (12.14.20) (83,416 pages). Dr. Ralph Baric’s emails with EcoHealth Alliance, Wuhan Institute of Virology, the U.S. National Academy of Sciences and experts in biodefense and infectious diseases.

See our reporting:

Rebekah Kading and Tony Schountz emails

Rebekah Kading and Tony Schountz (1.21.21) (2276 pages). Documents obtained from Colorado State University professors Rebekah Kading and Tony Schountz of the Center for Vector-Born Infectious Diseases (CVID).

See our reporting:

National Center for Biotechnology Information (NCBI)

NCBI Emails (12.29.20) (63 pages). Emails with coronavirus scientists who authored four key studies on coronavirus origins, about their revisions to genomic datasets associated with these studies.

See our reporting: Altered datasets raise more questions about reliability of key studies on coronavirus origins (12.29.20)

Rita Colwell emails

Rita Colwell emails with EcoHealth Alliance staff (11.18.20) (466 pages). Documents obtained from public records requests for emails of Rita Colwell, PhD, Distinguished University Professor, University of Maryland at College Park and Johns Hopkins University Bloomberg School of Public Health. She is a member of the EcoHealth Alliance board of directors.

See our reporting:

FOI lawsuits on origins of Covid-19, gain-of-function research and biolabs

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Posted on by Gary Ruskin

U.S. Right to Know, a nonprofit investigative public health group, has filed four lawsuits against federal agencies for violating provisions of the Freedom of Information Act (FOIA). The lawsuits are part of our efforts to uncover what is known about the origins of novel coronavirus SARS-CoV-2, leaks or mishaps at biosafety labs, and the risks of gain-of-function research that seeks to augment the infectivity or lethality of potential pandemic pathogens.

We have filed more than 90 state, federal, and international public records requests seeking information about the origins of SARS-CoV-2, and the risks of biosafety labs and gain-of-function research.

Read more about our findings so far, why we are conducting this investigation, recommended readings and documents we have obtained.

FOI lawsuits filed

(1) U.S. Department of State. On April 25, 2022, USRTK filed a lawsuit against the U.S. Department of State for violating provisions of FOIA. The lawsuit, filed in U.S. District Court for the District of Columbia, seeks documents and correspondence of State employees, including C.S. Eliot Kang, Ann Ganzer, David Feith, Bruce Turner, Robert Wood and Laura Gross, related to a State Dept. investigation of the origins of Covid-19, EcoHealth Alliance, gain-of-function research, dual use research of concern, the Global Virome Project, and other matters. Case 1:22-cv-01130-JMC.

(2) University of North Carolina at Chapel Hill. On April 18, 2022, USRTK filed a lawsuit against the University of North Carolina at Chapel Hill for violating the provisions of the North Carolina Public Records Act. The lawsuit, filed in North Carolina District Court in Orange County, seeks records for seven public records requests to the University of North Carolina, including: (1) emails between Prof. Ralph Baric, former Prof. Lishan Su or Ms. Toni Baric with the Wuhan Institute of Virology or the Wuhan Center for Disease Control and Prevention or the EcoHealth Alliance, or others; (2) emails to or from Prof. Ralph Baric containing any of the search terms “DEFUSE” or “DARPA” or “DTRA”. Case 22CV463.

(3) Defense Threat Reduction Agency. On January 14, 2022, USRTK filed a lawsuit against the DTRA for violating provisions of the FOIA. The lawsuit, filed in U.S. District Court for the Northern District of California, seeks: (1) finished intelligence, documents and reports about accidents, containment failures or deliberate release of biological agents from facilities in 21 countries around the world; (2) assessments of risks, hazards and efficacy of BSL-2, BSL-3 and BSL-4 containment schemes (including flaws, failings or weaknesses) in those same 21 countries; and, (3) grant proposals and other documents from the EcoHealth Alliance and Metabiota. Case 3:22-cv-00299-JCS. 

(4) National Institutes of Health. On November 8, 2021, USRTK filed a lawsuit against the NIH for violating provisions of the FOIA. The lawsuit (amended complaint filed 2/10/22), filed in U.S. District Court in Washington, DC, seeks records for nine FOIA requests to NIH regarding the origins of SARS-CoV-2, and communications between the NIH and EcoHealth Alliance or the Wuhan Institute of Virology. The records requests also included EcoHealth Alliance grant applications, scientific reviews, funding agreements, and correspondence with Dr. Erik Stemmy, NIAID (NIH) project officer, as well as documents regarding NIH’s Rocky Mountain Laboratories (RML), the DARPA-funded Preventing Emerging Pathogenic Threats (PREEMPT) Program, and communication between the NIH and the World Health Organization (WHO) concerning the origins of COVID-19. This is our second FOIA lawsuit against NIH related to the origins of COVID-19. Case 1:21-cv-02936-TSC.

(5) U.S. Agency for International Development (USAID): On October 14, 2021, USRTK filed a lawsuit against USAID for violating provisions of the FOIA. The lawsuit, filed in U.S. District Court for the Northern District of California, seeks records related to USAID funding and oversight of EcoHealth Alliance (EHA), which was a lead consortium partner in USAID-funded projects in the Emerging Pandemic Threats (EPT) program. Initiated in 2009, USAID’s EPT PREDICT programs funded collaborations between EHA and researchers at University of California, Davis; Wuhan Institute of Virology; Metabiota, Inc.; and others, to study the pandemic potential of infectious diseases including bat-associated coronaviruses. Case 3:21-cv-08058-SK.

(6) U.S. Department of Health and Human Services (HHS): On October 14, 2021, USRTK filed a lawsuit against HHS for violating provisions of the FOIA. The lawsuit, filed in U.S. District Court for the Northern District of California, seeks correspondence between senior HHS employees, including Robert Kadlec, assistant secretary for preparedness and response, with the World Health Organization’s director general’s office, and others, related to the SARS-CoV-2 pandemic. Case 3:21-cv-08056-TSH.

(7) University of Maryland: On October 6, 2021, USRTK filed a lawsuit against the University of Maryland for violating provisions of the Maryland Public Information Act.  The lawsuit, filed in Maryland Circuit Court for Prince George’s County, seeks correspondence and documents of Professor Rita R. Colwell, Distinguished University Professor at the University of Maryland at College Park, relevant to the origins of the ongoing COVID-19 pandemic. Colwell serves on the board of directors of the EcoHealth Alliance, which funded and conducted research with bat coronaviruses closely related to SARS-CoV-2 in collaboration with the Wuhan Institute of Virology and others. Case CAL21-11730.

(8) U.S. Food and Drug Administration: On Feb. 4, 2021, USRTK filed a lawsuit against the U.S. Food and Drug Administration (FDA) for violating provisions of FOIA.  The lawsuit, filed in U.S. District Court for the Northern District of California, seeks documents and correspondence with or about China’s Wuhan Institute of Virology, the Wuhan Center for Disease Control and Prevention, and the EcoHealth Alliance, which partnered with and funded the Wuhan Institute of Virology, among other subjects. Case 21-cv-00884-KAW.

(9) U.S. Department of Education: On Dec. 17, 2020 USRTK filed a lawsuit against the U.S. Department of Education for violating provisions of FOIA. The lawsuit, filed in U.S. District Court for the Northern District of California, seeks documents that the Education Department requested from the University of Texas’ Medical Branch at Galveston about its funding agreements and scientific and/or research cooperation with China’s Wuhan Institute of Virology. Case 3:20-cv-09117-DMR.

(10) U.S. Department of State: On Nov. 30, 2020 USRTK filed a lawsuit against the U.S. Department of State for violating provisions of FOIA. The lawsuit, filed in U.S. District Court for the Northern District of California, seeks documents and correspondence with or about China’s Wuhan Institute of Virology, the Wuhan Center for Disease Control and Prevention, and the EcoHealth Alliance, which partnered with and funded the Wuhan Institute of Virology, among other subjects. See news release. Case 3:20-cv-08415-JCS.

(11) National Institutes of Health: On Nov. 5, 2020 USRTK filed a lawsuit against National Institutes of Health (NIH) for violating provisions of FOIA. The lawsuit, filed in U.S. District Court in Washington, D.C., seeks correspondence with or about organizations such as the Wuhan Institute of Virology and the Wuhan Center for Disease Control and Prevention, as well as the EcoHealth Alliance, which partnered with and funded the Wuhan Institute of Virology. See news release. Case 1:20-cv-03196-CKK.

U.S. Right to Know is an investigative research group focused on promoting transparency for public health. For more information about FOI lawsuits we have filed to vindicate the public’s right to know, see our FOIA litigation page.

Why we are researching the origins of Covid-19, gain-of-function research and biolabs

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Posted on by Sainath Suryanarayanan

See our reporting on the origins of Covid-19 for updates on our investigation, and we are posting documents from our investigation here. Sign up here to receive weekly updates. 

In July 2020, U.S. Right to Know began submitting public records requests in pursuit of data from public institutions in an effort to discover what is known about the origins of the novel coronavirus SARS-CoV-2, which causes the disease Covid-19. Since the start of the outbreak in Wuhan, SARS-CoV-2 has killed over 3.38 million people, while sickening millions more in a global pandemic that continues to unfold.

We are also researching accidents, leaks and other mishaps at laboratories where pathogens of pandemic potential are stored and modified, and the public health risks of gain-of-function (GOF) research, which involves experiments to enhance aspects of the functionality of deadly pathogens, such as viral load, infectivity and transmissibility.

The public and global scientific community have a right to know what data exists about these matters.  We will report here any useful findings that may emerge from our research.

U.S. Right to Know is an investigative research group focused on promoting transparency for public health.

Why are we conducting this research?

We are concerned that the national security apparatuses of the United States, China and elsewhere, and the university, industry and governmental entities with which they collaborate, may not provide a full and honest picture of the origins of SARS-CoV-2 and the dangers of gain-of-function research.

Through our research, we seek to answer three questions:

  • What is known about the origins of SARS-CoV-2?
  • Are there accidents or mishaps that have occurred at biosafety or GOF research facilities that have not been reported?
  • Are there concerns about ongoing safety risks of biosafety laboratories or GOF research that have not been reported?

What are the origins of SARS-CoV-2?

In late December 2019, in the city of Wuhan, China, news emerged of the deadly infectious disease called COVID-19, caused by SARS-CoV-2, a novel coronavirus that had not been known to exist before. The origins of SARS-CoV-2 are not known. There are two main hypotheses.

Researchers in professional networks associated with the Wuhan Institute of Virology (WIV) and EcoHealth Alliance, a U.S. non-profitthat has garnered millions of dollars from taxpayer-funded grants to collaborate with WIV on coronavirus research, have written that the novel virus likely originated via natural selection in animal hosts, with its reservoir in bats. This “zoonotic” origin hypothesis was further strengthened by claims that the new coronavirus outbreak started in a “wildlife” market in Wuhan, the Huanan seafood market, where potentially infected animals may have been sold. (However, at least one-third of the first cluster of infected patients, including the earliest known case of infection from December 1, 2019, had neither direct or indirect contact with the Huanan seafood market’s human and animal attendees.)

The zoonosis hypothesis is currently the prevailing hypothesis of origin. However, the zoonotic origin of SARS-CoV-2 has yet to be definitively established, and some researchers have pointed out that it rests upon contradictory observations that require further investigation.

For further reading on these topics, see our reading list: What are the origins of SARS-CoV-2? What are the risks of gain-of-function research?

Some scientists have suggested a different hypothesis of origin; they speculate that the SARS-CoV-2 is the result of an accidental release of a wild-type or lab-modified strain of a closely related SARS-like virus that had been stored in biosafety facilities conducting coronavirus research in Wuhan, such as the WIV or the Wuhan Centers for Disease Control and Prevention.

Importantly, a lab-origin scenario does not necessarily exclude the zoonosis hypothesis because SARS-CoV-2 could be the outcome of lab-modifications conducted on unreported versions of SARS-like bat coronaviruses stored in WIV, or merely collection and storage of such coronaviruses. Critics of lab-origin hypotheses have dismissed these ideas as unsubstantiated speculations and conspiracy theories.

To date, there is not sufficient evidence to definitively reject either zoonotic origin or lab-origin hypotheses. We do know, based on published research articles and U.S. federal grants to the EcoHealth Alliance for funding WIV’s coronavirus research, that WIV stored hundreds of potentially dangerous SARS-like coronaviruses, and performed GOF experiments on coronaviruses in collaboration with U.S. universities, and there were biosafety concerns with WIV’s BSL-4 laboratory.

But so far, there has been no independent audit of WIV’s laboratory records and databases, and little information exists about the WIV’s internal operations. The WIV has removed from its website information such as the 2018 visit of U.S. science diplomats, and closed off access to its virus database and laboratory records of the coronavirus experiments being conducted by WIV scientists.

Understanding the origins of SARS-CoV-2 has crucial policy implications for public health and food systems. SARS-CoV-2’s potential zoonotic origin raises questions about policies that promote the expansion of industrial farming and livestock operations, which can be major drivers of the emergence of novel and highly pathogenic viruses, deforestation, biodiversity loss and habitat encroachment. The possibility that SARS-CoV-2 may have emerged from a biodefense laboratory raises questions about whether we ought to have these facilities, where wild-derived microbial pathogens are stored and modified via GOF experiments.

SARS-CoV-2 origin investigations raise vital questions about transparency deficits regarding research on potential pandemic pathogens, and the imperatives and players that are creating increasingly widespread biosafety containment facilities where dangerous viruses are stored and modified to make them more deadly.

Is gain-of-function research worth the risk?

There is significant evidence that biosafety laboratories have had many accidents, breaches, and containment failures, and that the potential benefits of gain-of-function research may not be worth the risks of causing potential pandemics.

GOF research of concern modifies and tests dangerous pathogens such as Ebola, H1N1 influenza virus, and the SARS-related coronaviruses under the rubric of developing medical counter-measures (such as vaccines). As such, it is of interest not only to biotechnology and pharmaceutical industry but also to biodefense industry, which is concerned with the potential use of GOF research for acts of biowarfare.

GOF research on deadly pathogens is a major public health concern. Reports of accidental leaks and biosafety breaches at GOF research sites are not uncommon. After a distinguished group of virologists published an urgent consensus statement on July 14, 2014 calling for a moratorium on GOF research of concern, the U.S. government under President Barack Obama’s administration imposed a  “funding pause” on GOF experiments involving dangerous pathogens, including coronaviruses and influenza viruses.

The federal funding pause on GOF research of concern was lifted in 2017 after a period in which the U.S. government undertook a series of deliberations to assess the benefits and risks associated with studies involving GOF research of concern.

Seeking transparency

We are concerned that data that is crucial to public health policy about the origins of SARS-CoV-2, and the hazards of biosafety laboratories and gain-of-function research, may be hidden within biodefense networks of the national security apparatuses of the United States, China, and elsewhere.

We will try to shed some light on these matters through the use of public records requests. Perhaps we will succeed. We could easily fail. We will report anything useful that we may find.

Sainath Suryanarayanan, PhD, is staff scientist at U.S. Right to Know and co-author of the book, “Vanishing Bees: Science, Politics and Honeybee Health” (Rutgers University Press, 2017).

New emails show scientists’ deliberations on how to discuss SARS-CoV-2 origins 

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Posted on by Sainath Suryanarayanan

Newly obtained emails offer glimpses into how a narrative of certainty developed about the natural origins of the novel coronavirus SARS-CoV-2, while key scientific questions remained. The internal discussions and an early draft of a scientists’ letter show experts discussing gaps in knowledge and unanswered questions about lab origin, even as some sought to tamp down on “fringe” theories about the possibility the virus came from a lab.

Influential scientists and many news outlets have described the evidence as “overwhelming” that the virus originated in wildlife, not from a lab. However, a year after the first reported cases of SARS-CoV-2 in the Chinese city of Wuhan, little is known how or where the virus originated. Understanding the origins of SARS-CoV-2, which causes the disease COVID-19, may be crucial to preventing the next pandemic.

The emails of coronavirus expert Professor Ralph Baric — obtained through a public records request by U.S. Right to Know — show conversations between National Academy of Sciences (NAS) representatives, and experts in biosecurity and infectious diseases from U.S. universities and the EcoHealth Alliance.

On Feb. 3, the White House Office of Science and Technology Policy (OSTP) asked the National Academies of Sciences, Engineering and Medicine (NASEM) to “convene meeting of experts… to assess what data, information and samples are needed to address the unknowns, in order to understand the evolutionary origins of 2019-nCoV, and more effectively respond to both the outbreak and any resulting misinformation.”

Baric and other infectious disease experts were involved in drafting the response. The emails show the experts’ internal discussions and an early draft dated Feb. 4.

The early draft described “initial views of the experts” that “the available genomic data are consistent with natural evolution and that there is currently no evidence that the virus was engineered to spread more quickly among humans.” This draft sentence posed a question, in parentheses: “[ask experts to add specifics re binding sites?]” It also included a footnote in parentheses: “[possibly add brief explanation that this does not preclude an unintentional release from a laboratory studying the evolution of related coronaviruses].”

In one email, dated Feb. 4, infectious disease expert Trevor Bedford commented: “I wouldn’t mention binding sites here. If you start weighing evidence there’s a lot to consider for both scenarios.” By “both scenarios,” Bedford appears to refer to lab-origin and natural-origin scenarios.

The question of binding sites is important to the debate about the origins of SARS-CoV-2. Distinctive binding sites on SARS-CoV-2’s spike protein confer “near-optimal” binding and entry of the virus into human cells, and make SARS-CoV-2 more contagious than SARS-CoV. Scientists have argued that SARS-CoV-2’s unique binding sites could have originated either as a result of natural spillover in the wild or deliberate laboratory recombination of an as-yet-undisclosed natural ancestor of SARS-CoV-2.

The final letter published Feb. 6 did not mention binding sites or the possibility of a laboratory origin. It does make clear that more information is necessary to determine the origins of SARS-CoV-2. The letter states, “The experts informed us that additional genomic sequence data from geographically – and temporally – diverse viral samples are needed to determine the origin and evolution of the virus. Samples collected as early as possible in the outbreak in Wuhan and samples from wildlife would be particularly valuable.”

The emails show some experts discussing the need for clear language to counter what one described as “crackpot theories” of lab origin. Kristian Andersen, lead author of an influential Nature Medicine paper asserting a natural origin of SARS-CoV-2, said the early draft was “great, but I do wonder if we need to be more firm on the question of engineering.” He continued, “If one of the main purposes of this document is to counter those fringe theories, I think it’s very important that we do so strongly and in plain language…”

In his response, Baric aimed at conveying a scientific basis for SARS-CoV-2’s natural origin. “I do think we need to say that the closest relative to this virus (96%) was identified from bats circulating in a cave in Yunnan, China. This makes a strong statement for animal origin.”

The final letter from the NASEM presidents does not take a position on the virus origin. It states that, “Research studies to better understand the origin of 2019-nCoV and how it relates to viruses found in bats and other species are already underway. The closest known relative of 2019-nCoV appears to be a coronavirus identified from bat-derived samples collected in China.” The letter referenced two studies that were conducted by EcoHealth Alliance and Wuhan Institute of Virology. Both posit a natural origin for SARS-CoV-2.

A few weeks later, the NASEM presidents’ letter appeared as an authoritative source for an influential scientists’ statement published in The Lancet that conveyed far more certainty about the origins of SARS-CoV-2. USRTK previously reported that EcoHealth Alliance President Peter Daszak drafted that statement, which asserted that “scientists from multiple countries…overwhelmingly conclude that this coronavirus originated in wildlife.” This position, the statement notes, is “further supported by a letter from the presidents of the US National Academies of Science, Engineering, and Medicine.”

The subsequent appointments of Peter Daszak and other EcoHealth Alliance allies to The Lancet COVID19 Commission and Daszak to the World Health Organization’s investigations of SARS-CoV-2’s origins means the credibility of these efforts are undermined by conflicts of interest, and by the appearance that they have already pre-judged the matter at hand.

——–

“issues we should probably avoid”

The Baric emails also show a NAS representative suggesting to U.S. scientists they should “probably avoid” questions about SARS-CoV-2’s origin in bilateral meetings they were planning with Chinese COVID-19 experts. The emails in May and June 2020 discussed plans for the meetings. Participating American scientists, many of whom are members of the NAS Standing Committee on emerging infectious diseases and 21st-century health threats, included Ralph Baric, Peter Daszak, David Franz, James Le Duc, Stanley Perlman, David Relman, Linda Saif, and Peiyong Shi.

The participating Chinese scientists included George Gao, Zhengli Shi, and Zhiming Yuan. George Gao is Director of China CDC. Zhengli Shi leads the coronavirus research at Wuhan Institute of Virology, and Zhiming Yuan is Director of WIV.

In an email to American participants about a planning session, NAS Senior Program Officer Benjamin Rusek described the purpose of the meeting: “to fill you in on the dialogue background, discuss the topics/questions (list in your invitation letter and attached) and issues we should probably avoid (origin questions, politics)…”

For more information

Link to University of North Carolina Professor Ralph Baric’s emails can be found here: Baric emails (83,416 pages)

U.S. Right to Know is posting documents from our public records requests for our biohazards investigation. See: FOI documents on origins of SARS-CoV-2, hazards of gain-of-function research and biosafety labs.

Written by Sainath Suryanarayanan

EcoHealth Alliance orchestrated key scientists’ statement on “natural origin” of SARS-CoV-2

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Posted on by Sainath Suryanarayanan

Update 2.15.21 – Newly surfaced Daszak email: “No need for you to sign the ‘Statement’ Ralph!!” 

Emails obtained by U.S. Right to Know show that a statement in The Lancet authored by 27 prominent public health scientists condemning “conspiracy theories suggesting that COVID-19 does not have a natural origin” was organized by employees of EcoHealth Alliance, a non-profit group that has received millions of dollars of U.S. taxpayer funding to genetically manipulate coronaviruses with scientists at the Wuhan Institute of Virology.

The emails obtained via public records requests show that EcoHealth Alliance President Peter Daszak drafted the Lancet statement, and that he intended it to “not be identifiable as coming from any one organization or person” but rather to be seen as “simply a letter from leading scientists”. Daszak wrote that he wanted “to avoid the appearance of a political statement”.

The scientists’ letter appeared in The Lancet on February 18, just one week after the World Health Organization announced that the disease caused by the novel coronavirus would be named COVID-19.

The 27 authors “strongly condemn[ed] conspiracy theories suggesting that COVID-19 does not have a natural origin,” and reported that scientists from multiple countries “overwhelmingly conclude that this coronavirus originated in wildlife.” The letter included no scientific references to refute a lab-origin theory of the virus. One scientist, Linda Saif, asked via email whether it would be useful “to add just one or 2 statements in support of why nCOV is not a lab generated virus and is naturally occuring? Seems critical to scientifically refute such claims!” Daszak responded, “I think we should probably stick to a broad statement.”

Growing calls to investigate the Wuhan Institute of Virology as a potential source of SARS-CoV-2 have led to increased scrutiny of EcoHealth Alliance. The emails show how members of EcoHealth Alliance played an early role in framing questions about possible lab origin of SARS-CoV-2 as “crackpot theories that need to be addressed,” as Daszak told The Guardian.

Although the phrase “EcoHealth Alliance” appeared only once in The Lancet statement, in association with co-author Daszak, several other co-authors also have direct ties to the group that were not disclosed as conflicts of interest. Rita Colwell and James Hughes are members of the Board of Directors of EcoHealth Alliance, William Karesh is the group’s Executive Vice President for Health and Policy, and Hume Field is Science and Policy Advisor.

The statement’s authors also claimed that the “rapid, open, and transparent sharing of data on this outbreak is now being threatened by rumours and misinformation around its origins.” Today, however, little is known about the origins of SARS-CoV-2, and investigations into its origins by the World Health Organization and The Lancet COVID-19 commission have been shrouded in secrecy and mired by conflicts of interests.

Peter Daszak, Rita Colwell, and The Lancet Editor Richard Horton did not provide comments in response to our requests for this story.

Written by Sainath Suryanarayanan

For more information

A link to the entire batch of EcoHealth Alliance emails can be found here: EcoHealth Alliance emails: University of Maryland (466 pages)

U.S. Right to Know is posting documents obtained through public freedom of information (FOI) requests for our Biohazards investigation in our post: FOI documents on origins of SARS-CoV-2, hazards of gain-of-function research and biosafety labs.

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