Zhengli Shi Edits to Widely-Cited EMI Commentary

Print Email Share Tweet

A new document shows Zhengli Shi’s edits to a draft of the Emerging Microbes & Infections commentary, “No credible evidence supporting the claims of the laboratory engineering of SARS-CoV-2.” Zhengli Shi is a leading Chinese virologist at the Wuhan Institute of Virology.

Shi proposed three edits of note. First, she proposed changing the presentation of the number of nucleotides that differed between RaTG13, which was the closest relative of SARS-CoV-2 identified at that time, and SARS-CoV-2. The authors wrote this difference was “greater than 1000 nucleotides.”  Shi proposed deleting “1000” and replacing it with “1100” nucleotides. This edit appears to maximize the presentation of the difference between the two viruses.

Second, Shi proposed deleting a paragraph discussing the mouse-adapted SARS-CoV virus, MA15 (that had been used in Ralph Baric’s lab in collaboration with Shi), and how its serial passage had increased viral replication and lung pathology in mice. This appears to be an effort at distancing from the gain-of-function debate surrounding the research done together by Shi, Baric and the EcoHealth Alliance.

Third, Shi edited a statement on bats as natural reservoirs, and civets as intermediate hosts, of SARS-CoV.

Since the publication of the EM&I commentary, a bat coronavirus with greater similarity to SARS-CoV-2 than RaTG13 has been identified in bats in Laos. Three of the viruses identified, called BANAL-52, BANAL-103 and BANAL-236, have receptor binding domains (RBDs) that can bind to human ACE2 with greater affinity, and can infect human cells more readily, than RaTG13.

The Zhengli Shi attachment had been referred to in emails between Shan-Lu Liu, Lishan Su, and editor Shan Lu. U.S. Right to Know obtained the attachment through a Ohio Public Records Act request.

Wuhan Institute of Virology has many unreported bat virus samples, collaborating virologist says

Print Email Share Tweet

The Wuhan Institute of Virology (WIV) “has many bat samples not yet worked out or results published,” according to emails of Ohio State University virologist Shan-Lu Liu, which were obtained by U.S. Right to Know.

Shan-Lu Liu has collaborated with WIV’s chief coronavirologist Zhengli Shi. For example, Liu consulted with Shi on a Feb 26, 2020 commentary in Emerging Microbes & Infections (EMI), which tried to rebut the hypothesis that the novel coronavirus SARS-CoV-2 came from a lab.

The WIV, one of the world’s foremost coronavirus research institutes, is under investigation by U.S. governmental authorities, academic virologists and independent researchers and journalists as a potential source for SARS-CoV-2’s origin in Wuhan.

In February 2020, WIV scientists reported discovering the closest known relative of SARS-CoV-2, a bat coronavirus called RaTG13. RaTG13 has become central to the hypothesis that SARS-CoV-2 emerged from wildlife. However, key questions persist about the provenance of RaTG13 and about the reliability of the WIV scientists’ claims about the closest known bat coronavirus relatives of SARS-CoV-2.

Scientists have posited that SARS-CoV-2 may be a product of WIV’s experiments on an unpublished bat coronavirus that is more closely related to SARS-CoV-2 than RaTG13. However, this cannot be verified because WIV’s authorities shut down outside access to its virus database in September 2019.

Zhengli Shi has denied speculations that her lab was working in secret on other bat viruses. In an interview with Science magazine in July 2020, Shi wrote: “We tested all bat samples that we collected, including bat anal swabs, oral swabs and fecal samples, and 2,007 samples were positive for coronavirus. We did not find any viruses whose gene sequence is more similar to SARS-CoV-2 than RaTG13.”

The statement about the WIV working on many unpublished bat viruses occurred in an email exchange on Feb 16, 2020 between Shan-Lu Liu and University of Pennsylvania coronavirologist Susan Weiss. Discussing SARS-CoV-2’s origin, Weiss asked: “Do you think it could come from a bat virus- which one or an unpublished one? RaTg13 is the closest? Is it close enough in sequence? Do you think it came through an intermediate host and sequence drifted? This is a very chilling idea”

Liu replied: “I have looked at carefully the RaTG13 sequence, and it is unlikely from it – also see attached file. But we cannot rule out the possibility of other bat viruses from the lab – The Wuhan lab has many bat samples not yet worked out or results published. There are some concerns that some of their samples may not have been handled properly and leaked out of the lab…But just a possibility.”

The Emerging Microbes and Infections commentary made no mention of the WIV’s work on unpublished bat coronaviruses.

For more information

Ohio State University Professor Shan-Lu Liu’s emails, which U.S. Right to Know obtained through an Ohio Public Records Act request, can be found here: Shan-Lu Liu emails: Ohio State University (488 pages)

U.S. Right to Know is posting documents from our public records requests for our biohazards investigation. See: FOI documents on origins of SARS-CoV-2, hazards of gain-of-function research and biosafety labs.

Background page on U.S. Right to Know’s investigation into the origins of SARS-CoV-2.