Imibhalo yaseColorado State University ocwaningweni lwe-bat pathogen

Phrinta imeyili Ungahlukıselana Ephathwayo

Lokhu okuthunyelwe kuchaza imibhalo yoSolwazi baseColorado State University (CSU) uRebekah Kading noTony Schountz, i-US Right to Know eyithole esicelweni samarekhodi omphakathi. UKading noSchountz bangama-virologists abacwaninga amagciwane ahlobene nelulwane ezindaweni ezishisayo emhlabeni jikelele. Basebenzisana ne-EcoHealth Alliance, uMnyango Wezokuvikela wase-US (DoD) kanye ne-Defense Advanced Research Projects Agency (DARPA), uphiko lwezocwaningo nentuthuko yamasosha aseMelika.

Imibhalo inikeza amazwibela kufayela le- inkimbinkimbi yezempi-yezifundo zososayensi abafunda ukuthi bangavimbela kanjani ukugeleza kwamagciwane abangelwa ubhubhane avela kumalulwane. Imibhalo iphakamisa imibuzo mayelana nezingozi ezithathelanayo, ngokwesibonelo, zokuthunyelwa kwamalulwane namagundane atheleleke ngamagciwane ayingozi. Futhi aqukethe ezinye izinto eziphawuleka, kufaka phakathi:

  1. NgoFebhuwari 2017, abaxhumanisi beDoD boHlelo Lokusebenzisana Lokuzibandakanya Kwezinto Ezisongela Ezokuvikela kumemezela umfelandawonye omusha wamalulwane omhlaba wonke “ukwakha nokusimamisa amakhono ezwe nawesifunda ukukhiqiza ukuqonda okuthuthukile kwamalulwane nemvelo yawo ngaphansi kwesimo sezinto ezibangela ukuphepha.” Okuhambisana nalokhu, ama-imeyili show ukusebenzisana phakathi kwe-CSU, i-EcoHealth Alliance kanye ne-National Institutes of Health's Rocky Mountain Laboratories ukwakha indawo yokucwaninga amalulwane e-CSU ukukhulisa izifundo zokutheleleka ngamalulwane.
  2. Umfelandawonye wamalulwane womhlaba wonke waba yiqembu elibizwa ngeBat One Health Research Network (I-BOHRN). Ngo-2018, ososayensi abakhulu be-BOHRN babesebenza ne-DARPA kuphrojekthi ebizwa nge-PREEMPT. Amarekhodi e-CSU ku-PREEMPT kukhombisa ukuthi iRocky Mountain Laboratories, i-CSU kanye neMontana State University bakha imishanguzo "ehlukanisiwe" yokugoma ukusabalalisa kubantu bamalulwane "ukuvimbela ukuvela nokugeleza" kwamagciwane angaba ubhadane avela kumalulwane aye kubantu babantu. Inhloso yabo ukuthuthukisa “imishanguzo yokuzisabalalisa ” - okusakazeka ngokutheleleka phakathi kwamalulwane - ngethemba lokuqeda ama-pathogen ezinqolobaneni zabo zezilwane ngaphambi kokuphonswa kwabantu. Lolu cwaningo luyaphakama ukukhathazeka ngemiphumela engahlosiwe yokukhiphela obala izinhlangano ezizisakazele zofuzo, kanye nezingozi zemvelo zokuvela kwazo okungaziwa, ubudlova nokusabalala.
  3. Ukuthumela amalulwane namagundane atheleleke ngamagciwane ayingozi kudala amandla e-spillover engahlosiwe kubantu. UTony Schountz wabhala ku-EcoHealth Alliance VP uJonathan Epstein ngoMashi 30, 2020: “I-RML [Rocky Mountain Labs] ingenise inqolobane yegciwane le-Lassa ngokuthi izalelwe ekuthunjweni e-Afrika, bese kuthi inzalo ingeniswe ngqo ku-RML. Angazi noma amalulwane amahhashi angazalelwa yini ekuthunjweni, kodwa lokho kungaba yindlela yokunciphisa ukukhathazeka kwe-CDC. ” Igciwane le-Lassa isakazwa ngamagundane atholakala entshonalanga ye-Afrika. Kubanga ukugula okunamandla okubizwa nge-Lassa fever ebantwini, okuholela ekufeni okulinganiselwa ku-5,000 1 njalo ngonyaka (izinga lokufa elingu-XNUMX%).
  4. NgoFebhuwari 10, 2020, uMongameli we-EcoHealth Alliance uPeter Daszak uthumele i-imeyili ukucela abasayinela uhlaka lwe- The I-Lancet isitatimende "Ukugxeka kakhulu imibono yetulo ethi i-2019-nCoV ayinayo imvelaphi engokwemvelo." Kule imeyili, uDaszak wabhala: “UDkt. ULinda Saif, uJim Hughes, uRita Colwell, uWilliam Karesh noHume Field babhale isitatimende esilula sokweseka ososayensi, ezempilo yomphakathi kanye nabasebenzi bezokwelapha baseChina abalwa nalokhu kuqubuka (okunamathiselwe), futhi siyakumema ukuba uhlanganyele nathi njengabasayini bokuqala. ” Akazange akhulume ngokubandakanyeka kwakhe ekubhaleni isitatimende.  Ukubika kwethu kwangaphambili wabonisa lokho I-Daszak wabhala isitatimende esashicilelwa ku- I-Lancet.
  5. UTony Schountz ushintshisane ngama-imeyili nososayensi abalulekile beWuhan Institute of Virology (WIV) uPeng Zhou, uZhengli Shi noBen Hu. Ku- i-imeyili yango-Okthoba 30, 2018, USchountz uphakamise uZhengli Shi ukuthi abe “yinhlangano engahambisani nhlobo” phakathi kwe-CSU's Arthropod-borne and Infectious Disease Laboratory ne-WIV, okubandakanya “ukusebenzisana kumaphrojekthi afanele (isib. Ama-arboviruses namagciwane athwalwa ngamalulwane) nokuqeqeshwa kwabafundi.” UZhengli Shi waphendula kahle kusiphakamiso sikaSchountz. Amarekhodi awasikiseli ukuthi noma yikuphi ukusebenzisana okunjalo kwaqalwa.

Ukuze uthole ukwaziswa okwengeziwe

Isixhumanisi seqoqo lonke lemibhalo yaseColorado State University singatholakala lapha: Amarekhodi e-CSU

I-US Right to Know ithumela imibhalo etholwe ngenkululeko yomphakathi yolwazi (i-FOI) yezicelo uphenyo lwethu lweBiohazards kokuthunyelwe kwethu: Imibhalo ye-FOI ngemvelaphi ye-SARS-CoV-2, izingozi zokucwaninga ngomsebenzi kanye namalebhu e-biosafety.

Akukho ukubuyekezwa kontanga kwesengezo esifundweni esivelele semvelaphi ye-coronavirus?

Phrinta imeyili Ungahlukıselana Ephathwayo

Ijenali Nature akuzange kuhlolisise ukuthembeka kwezimangalo ezibalulekile ezenziwe ngoNovemba 17 isithasiselo kuya ku cwaningo ngemvelaphi yelulwane le-coronavirus SARS-CoV-2, ukuxhumana ne Nature abasebenzi basikisela.

NgoFebhuwari 3, 2020, ososayensi baseWuhan Institute of Virology babika ukuthi bathola isihlobo esiseduze kakhulu se-SARS-CoV-2, i-bat coronavirus ebizwa nge-RaTG13. I-RaTG13 isibe maphakathi emcabangweni wokuthi iSARS-CoV-2 yavela ezilwaneni zasendle.

Amakheli esengezo engaphendulwa imibuzo mayelana nokuvela kweRaTG13. Ababhali, uZhou et al., Bacacisile ukuthi bathole iRaTG13 ngo-2012-2013 "endaweni encane eshiyiwe eMojiang County, esifundazweni saseYunnan," lapho abavukuzi abayisithupha bahlupheka khona isifo sokuphefumula okunamandla ngemuva kokuchayeka endleni yelulwane, Futhi abathathu bashona. Uphenyo lwe- izimpawu zabavukuzi abagulayo zinganikeza imikhondo ebalulekile ngemvelaphi yeSARS-CoV-2. UZhou et al. babike ukuthi abatholanga ama-coronavirus ahlobene no-SARS kumasampula agcinwe abagibeli abagulayo, kodwa abazisekelanga izimangalo zabo ngemininingwane nangezindlela mayelana nokuhlolwa kwabo kanye nezilawuli zokuhlola.

Ukungabi khona kwemininingwane esemqoka kwisengezo kunakho kwaphakamisa eminye imibuzo ngokwethembeka kweZhou et al. funda. NgoNovemba 27, i-US Right to Know yabuza Nature imibuzo mayelana nezicelo zesengezo, futhi wakucela lokho Nature shicilela yonke imininingwane esekelayo uZhou et al. kungenzeka unikeze.

NgoDisemba 2, Nature INhloko Yezokuxhumana uBex Walton Waphendula ukuthi uZhou wokuqala et al. isifundo “besinembile kepha kungacaci,” nokuthi isengezo besifanelekile ipulatifomu yokushicilelwa ngemuva kokushicilelwa ukuthola ukucaciselwa. Ubuye wathi: “Mayelana nemibuzo yakho, singakuqondisa ukuthi uye kubabhali bephepha ukuthola izimpendulo, njengoba le mibuzo ayithinti ucwaningo esilushicilele kodwa kolunye ucwaningo olwenziwe ngababhali, esingakwazi ukuphawula ngalo ”(kugcizelelwa okwethu). Njengoba imibuzo yethu ihlobene nocwaningo oluchazwe kusengezo, i Nature Isitatimende sabamele sikhombisa ukuthi isengezo sikaZhou et al asizange sihlolwe njengocwaningo.

Sabuza umbuzo olandelayo ngoDisemba 2: “ngabe lesi sengezo sakhonjelwa ekubuyekezweni kontanga kanye / noma ekuqondisweni kokuhlelwa ngu Nature? ” UNks Walton akazange aphendule ngqo; yena Waphendula: “Ngokuvamile, abahleli bethu bazohlola ukuphawula noma ukukhathazeka okuphakanyiswe nathi ekuqaleni, babonisane nababhali, futhi bafune izeluleko kubabuyekezi boontanga nakwabanye ochwepheshe bangaphandle uma sikubona kunesidingo. Inqubomgomo yethu yobumfihlo isho ukuthi asikwazi ukuphawula ngendlela ethile yokuphathwa kwamacala ngamanye. ”

Kusukela Nature ubheka isengezo njenge- a post-isibuyekezo sokushicilelwa, futhi ayikubeki lokho kungezwa kokushicilelwa kokushicilelwa kumazinga afanayo okubukeza ontanga njengezincwadi zokuqala, kubonakala sengathi iZhou et al. isengezo asizange sibuyekezwe ngontanga.

Ababhali uZhengli Shi noPeng Zhou abaphendulanga imibuzo yethu mayelana yabo Nature Eyongeziwe.