Ucwaningo olusha lungeza ubufakazi bokuthi ukhula olubulala ukhula luphazamisa ama-hormone

Phrinta imeyili Ungahlukıselana Ephathwayo

Ucwaningo olusha lungeza ubufakazi obukhathazayo ekukhathazekeni kokuthi ukubulala ukhula okusetshenziswa kabanzi ikhemikhali glyphosate angaba namandla okuphazamisa ama-hormone abantu.

Ephepheni elishicilelwe ephephabhukwini I-Chemosphere okubizwa ngokuthi IGlyphosate nezimpawu ezibalulekile zokuphazamiseka kwe-endocrine: Ukubuyekezwa, abathathu bososayensi baphetha ngokuthi i-glyphosate ibonakala inezici ezisemqoka eziyisishiyagalombili kwezilishumi ezihambisana i-endocrine ephazamisa amakhemikhali . Ababhali baxwayisile, nokho, ukuthi izifundo ezizayo zamaqoqo zisadingeka ukuqonda kahle imithelela ye-glyphosate ohlelweni lomuntu lwe-endocrine.

Ababhali, uJuan Munoz, Tammy Bleak noGloria Calaf, ngamunye ohlangene neYunivesithi yaseTarapacá eChile, uthe iphepha labo libuyekeza okokuqala ukuhlanganisa ubufakazi bemishini ku-glyphosate njenge-endocrine-disruptting chemical (EDC).

Obunye bobufakazi bukhombisa ukuthi i-Roundup, i-herbicide eyaziwayo esekwe eMonsanto, ingaguqula i-biosynthesis yamahomoni ezocansi, ngokusho kwabaphenyi.

Ama-EDC angalingisa noma aphazamise amahomoni omzimba futhi axhumene nezinkinga zokukhula nezokuzala kanye nokungasebenzi kahle kobuchopho namasosha omzimba.

Leli phepha elisha lilandela ukushicilelwa ekuqaleni konyaka ukuhlanganiswa kwezifundo zezilwane okukhombise ukuvezwa kwe-glyphosate kunomthelela ezithweni zokuzala futhi kusongela ukuzala.

IGlyphosate yi-herbicide esetshenziswa kakhulu emhlabeni, edayiswa emazweni ayi-140. Yangeniswa ngokuthengisa ngonyaka we-1974 ngabakwaMonsanto Co, ikhemikhali liyisithako esisebenzayo emikhiqizweni ethandwayo efana neRoundup kanye namakhulu abanye ababulali bokhula abasetshenziswa ngabathengi, omasipala, izinsiza, abalimi, abasebenzisa igalofu, nabanye emhlabeni jikelele.

UDana Barr, uprofesa wase-Emory University eRollins School of Public Health, uthe ubufakazi “buvame ukuveza ngokusobala ukuthi i-glyphosate ine-endocrine ephazamisa izakhiwo.”

“Akuyona into engalindelekile ngoba i-glyphosate inokufana okuthile kwesakhiwo namanye ama-endocrine aphazamisa ukubulala izinambuzane; kodwa-ke, ikhathaza kakhulu ngoba ukusetshenziswa kwe-glyphosate kudlula kude eminye imithi yokubulala izinambuzane, ”kusho uBarr, oqondisa uhlelo esikhungweni sokucwaninga ngokuvezwa kwabantu esixhaswe yiNational Institutes of Health esikhishwe e-Emory. "IGlyphosate isetshenziswa ezitshalweni eziningi kakhulu nasezicelweni eziningi zokuhlala ezinjengokuchayeka kokuqoqeka nokuqoqekayo kungabonakala."

Phil Landrigan, umqondisi weGlobal Observatory on Pollution and Health, kanye noprofesa wesayensi yezinto eziphilayo
eBoston College, uthe ukubuyekeza kudonse ndawonye "ubufakazi obuqinile" bokuthi i-glyphosate iyisiphazamisi se-endocrine.

“Umbiko uhambisana nenqwaba yezincwadi ezibonisa ukuthi i-glyphosate inemiphumela engemihle yezempilo - okutholakele okuguqula isikhathi eside sokusebenza kukaMonsanto ukuvezwa kwe-glyphosate njengekhemikhali enobungozi engenayo imithelela emibi empilweni yabantu, ”kusho uLandrigan.

Ama-EDC bekuyinto ekhathazayo kusukela ngama-1990s ngemuva kochungechunge lwezincwadi eziphakamise ukuthi amanye amakhemikhali asetshenziswa kakhulu kuma-pesticides, izinyibilikisi zezimboni, amapulasitiki, okokuhlanza, nezinye izinto angaba namandla okuphazamisa ukuxhumana phakathi kwamahomoni nama-receptors awo.

Ososayensi ngokuvamile babona izakhiwo eziyishumi ezisebenzayo zama-ejenti aguqula isenzo se-hormone, ebhekisa kulezi njengezici eziyishumi "eziyinhloko" zabaphazamisi be-endocrine. Izici eziyishumi zimi kanje:

Ama-EDC anga:

  • Ukusatshalaliswa kwama-hormone okuguqula amazinga wokujikeleza kwamahomoni
  • Yenza ushintsho ku-hormone metabolism noma imvume
  • Guqula isiphetho samaseli akhiqiza ama-hormone noma aphendula nge-hormone
  • I-Alter hormone receptor expression
  • Hlanganisa ama-hormone receptors
  • Hlanganyela noma usebenze ama-hormone receptors
  • Ukudluliswa kwesiginali eguquguqukayo kumaseli aphendula ama-hormone
  • Yenza ukuguqulwa kwe-epigenetic kumaseli akhiqiza ama-hormone noma aphendula ama-hormone
  • Alter hormone synthesis
  • Ukuhambisa ama-hormone okuhamba ngaphesheya kwezingqamuzana zeseli

Ababhali bephepha elisha bathe ukubuyekezwa kwemininingwane yemishini kukhombisile ukuthi i-glyphosate ihlangabezane nazo zonke izici ezibalulekile ngaphandle kwezimbili: "Mayelana ne-glyphosate, abukho ubufakazi obuhambisana namandla aphikisayo ama-hormonal receptors," kusho bona. Futhi, "abukho ubufakazi bokuthi kunomthelela ekuguqulweni kwamahomoni noma ekususweni," ngokusho kwabalobi.

Ucwaningo olwenziwe emashumini ambalwa edlule lubhekise kakhulu kwizixhumanisi ezitholakala phakathi kwe-glyphosate nomdlavuza, ikakhulukazi i-non-Hodgkin lymphoma (NHL.) Ngo-2015, i-World Health Organization's International Agency for Research on Cancer i-glyphosate ehlukanisiwe njenge-carcinogen yabantu.

Bangaphezu kuka-100,000 abantu bamangalele uMonsanto e-United States okusolwa ukutholakala kwemithi yokubulala ukhula egxilwe enkampanini ye-glyphosate kubangele bona noma abathandekayo babo ukuba bathuthukise i-NHL.

Abamangali ecaleni lamacala ezweni lonke bathi iMonsanto sekuyisikhathi eside ifuna ukufihla izingozi zemithi yayo yokubulala ukhula. IMonsanto ilahlekelwe izivivinyo ezintathu kwezintathu kanti umnikazi wayo waseGerman uBayer AG usebenzise unyaka nohhafu odlule uzama ukuhlala amacala aphume enkantolo.

Ababhali bephepha elisha baqaphela ubuningi be-glyphosate, bethi "ukusetshenziswa okukhulu" kwaleli khemikhali "kuholele ekusakazekeni kwemvelo okubanzi," kufaka phakathi ukuvezwa okukhulayo okuxhumene nokusetshenziswa komuntu kombulali wokhula ngokudla.

Abaphenyi bathi yize abalawuli bethi amazinga ezinsalela ze-glyphosate atholakala kakhulu ekudleni aphansi ngokwanele ukuthi aphephe, "ngeke bakwazi ukubekeka engcupheni" yabantu abadla ukudla okune-chemical, ikakhulukazi okusanhlamvu nezinye izitshalo- ukudla okusekelwe, okuvame ukuba namazinga aphezulu kunobisi, inyama noma imikhiqizo yenhlanzi.

Imibhalo kahulumeni wase-US ikhombisa ukuthi izinsalela ze-glyphosate zitholakele ezinhlotsheni eziningi zokudla, kufaka phakathi uju oluphilayo, Futhi i-granola nabaqhekezi.

Abaphenyi bakahulumeni waseCanada nabo babike izinsalela ze-glyphosate ekudleni. Umbiko owodwa okhishwe ngo-2019 ososayensi abavela e-Agri-Food Laboratories yaseCanada e-Alberta Ministry of Agriculture and Forestry bathola i-glyphosate kuma-sampuli ayi-197 kwangu-200 oju abaluhlolayo.

Ngaphandle kokukhathazeka ngemithelela ye-glyphosate empilweni yomuntu, kufaka phakathi nokuchayeka ekudleni, abalawuli base-US bakuvikele ngokuqinile ukuphepha kwamakhemikhali. I- Isikhungo Sokuvikelwa Kwemvelo sigcina ukuthi ayitholakalanga "noma iziphi izingozi empilweni yomuntu ngenxa yokuchayeka ku-glyphosate. ”