Ucwaningo olusha luthola izinguquko ezihlobene ne-glyphosate ku-gut microbiome

Phrinta imeyili Ungahlukıselana Ephathwayo

Ucwaningo olusha lwezilwane olwenziwe iqembu labaphenyi baseYurophu lithole ukuthi amazinga aphansi okhula olubulala ukhula amakhemikhali glyphosate kanye nomkhiqizo osuselwa ku-glyphosate-based Roundup kungashintsha ukwakheka kwe-gut microbiome ngezindlela ezingaxhunyaniswa nemiphumela emibi yezempilo.

Leli phepha, ishicilelwe ngoLwesithathu kulo magazini Impilo Yemvelo, ibhalwe ngabaphenyi abayi-13, kubandakanya nomholi oqhuba izifundo uDkt.Michael Antoniou, oyinhloko yeGene Expression and Therapy Group eMnyangweni Wezokwelapha Nemolekyuli Yezakhi zofuzo eKing's College eLondon, noDkt. iqembu elifanayo. Ososayensi abavela eRamazzini Institute eBologna, e-Italy, babambe iqhaza ocwaningweni njengoba kwenza ososayensi baseFrance nabaseNetherlands.

Imiphumela ye-glyphosate ku-gut microbiome itholwe ukuthi ibangelwe yindlela efanayo yokusebenza lapho i-glyphosate isebenza ukubulala ukhula nezinye izitshalo, kusho abacwaningi.

Amagciwane asemathunjini omuntu afaka izinhlobo ezahlukahlukene zamagciwane kanye nesikhunta esinomthelela emisebenzini yokuzivikela ezifweni nakwezinye izinqubo ezibalulekile, nokuphazamiseka kwalolo hlelo kungaba nomthelela ezigulini zezifo, kusho abacwaningi.

"Kokubili i-glyphosate ne-Roundup kube nomthelela ekubunjweni kwenani lamagciwane," kusho u-Antoniou kusho engxoxweni. “Siyazi ukuthi amathumbu ethu ahlala ezinkulungwaneni zezinhlobo ezahlukahlukene zamagciwane kanye nokulinganisela ekwakhekeni kwawo, futhi okubaluleke kakhulu ekusebenzeni kwawo, kubalulekile empilweni yethu. Ngakho-ke noma yini ephazamisayo, ephazamisa kabi, i-gut microbiome… inamandla okudala impilo ebuthaka ngoba sisuka ekusebenzeni okulinganiselayo okulungele impilo kuya ekusebenzeni okungalingani okungaholela ezinhlotsheni eziningi zezifo ezahlukahlukene. ”

Bona ingxoxo kaCarey Gillam uDkt. Michael Antonoiu noDkt. Robin Mesnage ngocwaningo lwabo olusha olubheka umthelela we-glyphosate kwi-gut microbiome.

Ababhali bephepha elisha bathe banqume ukuthi, ngokungahambisani nokunye okushiwo ngabagxeki bokusetshenziswa kwe-glyphosate, i-glyphosate ayisebenzi njenge-antibiotic, ibulala amagciwane adingekayo emathunjini.

Esikhundleni salokho, bathola - okokuqala ngqa, bathi - ukuthi isibulala-zinambuzane siphazamise ngendlela engaba yingozi kakhulu emzileni wamakhemikhali wamakhemikhali wamathumbu amabhaktheriya ezilwane ezisetshenziswe ekuhlolweni. Lokho kuphazamiseka kwaqokonyiswa ngoshintsho ezintweni ezithile esiswini. Ukuhlaziywa kwamathumbu negazi biochemistry kuveze ubufakazi bokuthi lezi zilwane zingaphansi kwengcindezi ye-oxidative, isimo esihambisana nokulimala kwe-DNA nomdlavuza.

Abaphenyi bathi akucaci ukuthi ukuphazamiseka okuphakathi kwegciwane le-microbiome kuthinte kanjani ukucindezela komzimba.

Inkomba yengcindezi ye-oxidative yacaca kakhulu ekuhlolweni kusetshenziswa i-herbicide esekwe eglyphosate ebizwa ngeRoundup BioFlow, umkhiqizo womnikazi weMonsanto uBayer AG, kusho ososayensi.

Ababhali bokucwaninga bathi benza izifundo eziningi ukuzama ukucacisa ukuthi ngabe ingcindezi ye-oxidative abayibonayo nayo ilimaza i-DNA, ezonyusa ingozi yomdlavuza.

Ababhali bathe kudingeka ucwaningo olwengeziwe ukuqonda kahle imithelela yempilo ye-glyphosate inhibition yendlela ekhazimulayo nokunye ukuphazamiseka kwemethambo ku-gut microbiome nasegazini kepha ukutholwa kokuqala kungasetshenziswa ekwakhiweni kwama-bio-markers wezifundo ze-epidemiological kanye nokuqonda uma i-glyphosate herbicides ingaba nemiphumela yezinto eziphilayo kubantu.

Ocwaningweni, amagundane abesifazane anikezwa i-glyphosate nomkhiqizo we-Roundup. Amanani ahanjiswa ngamanzi okuphuza ahlinzekwa izilwane futhi anikezwa emazingeni amele ukungena nsuku zonke okwamukelekayo okubhekwa njengokuvikelekile ngabalawuli baseYurophu nabaseMelika.

U-Antoniou uthe imiphumela yocwaningo yakhela kolunye ucwaningo olwenza kucace ukuthi izilawuli zithembele ezindleleni eseziphelelwe yisikhathi lapho kunqunywa ukuthi yimaphi amazinga “aphephile” e-glyphosate namanye ama-pesticides ekudleni nasemanzini. Izinsalela zemithi yokubulala izinambuzane ezisetshenziswa kwezolimo zivame ukutholakala ebangeni lokudla okusetshenziswa njalo.

"Abalawuli kumele bangene ekhulwini lama-XNUMX leminyaka, bayeke ukuhudula izinyawo zabo… bamukele izinhlobo zokuhlaziya esikwenzile kulolu cwaningo," kusho u-Antoniou. Uthe ukwenziwa kwamangqamuzana, okuyingxenye yegatsha lesayensi eyaziwa ngokuthi “OMICS,” kuguqula isisekelo solwazi mayelana nemithelela ukuchayeka kwamakhemikhali okunayo empilweni.

Isifundo segundane kodwa esakamuva ochungechungeni lwezivivinyo zesayensi ezihlose ukunquma ukuthi ngabe i-glyphosate ne-glyphosate-based herbicides - kufaka phakathi i-Roundup - ingaba yingozi kubantu, ngisho nasemazingeni abalawuli be-exposure bathi baphephile.

Izifundo eziningi ezinjalo zithole ukukhathazeka okuningi, kufaka phakathi eyodwa eyanyatheliswa ngoNovemba  ngabaphenyi abavela eNyuvesi yaseTurku eFinland abathi bakwazile ukuthola, "ngokulinganisela okulindelekile," ukuthi cishe amaphesenti angama-54 ezinhlobo ezisengxenyeni ye-gut microbiome yomuntu "angazwela" ku-glyphosate.

Njengoba abacwaningi banda bheka ukuqonda i-microbiome yomuntu neqhaza eliyidlalayo empilweni yethu, imibuzo mayelana nemithelela engaba khona ye-glyphosate kwi-gut microbiome bekungeyona nje impikiswano emibuthanweni yesayensi, kodwa futhi nasezinkantolo.

Ngonyaka odlule, iBayer bavuma ukukhokha u- $ 39.5 million ukuxazulula izimangalo zokuthi iMonsanto inezikhangiso ezidukisayo eziqinisekisa ukuthi i-glyphosate yenze kuphela i-enzyme ezitshalweni futhi ayinakuba nomthelela ofanayo ezifuyweni nakubantu. Abamangali kuleli cala kuthiwa i-glyphosate babhekise enzyme etholakala kubantu nasezilwaneni eziqinisa amasosha omzimba, ukugaya nokusebenza kwengqondo.

I-Bayer, eyathola ifa lomkhiqizo we-herbicide wase-Monsanto's glyphosate kanye nephothifoliyo yezimbewu ezakhiwe ngezofuzo ngesikhathi ithenga inkampani ku-2018, igcizelela ukuthi inqwaba yezifundo zesayensi emashumini eminyaka iqinisekisa ukuthi i-glyphosate ayibangeli umdlavuza. Isikhungo Sokuvikelwa Kwezemvelo e-US kanye nezinye izinhlaka eziningi ezilawula umhlaba nazo azibheki imikhiqizo ye-glyphosate njenge-carcinogenic.

Kepha i-World Health Organisation's International Agency for Research on Cancer ngonyaka ka-2015 yathi ukubuyekezwa kocwaningo lwesayensi kutholakale ubufakazi obanele bokuthi i-glyphosate iyi-carcinogen yabantu.

Kusukela ngaleso sikhathi, iBayer ilahlekelwe yizilingo ezintathu kwezintathu ezilethwe ngabantu abasola umdlavuza wabo ngokuvezwa yimithi yokubulala ukhula kaMonsanto, kanti iBayer ngonyaka odlule ithe izokhokha cishe ama- $ 11 billion ukukhokhela izimangalo ezifanayo ezingaphezu kwezingu-100,000.