Olunye uphononongo lweRoundup lufumana amakhonkco kwiingxaki ezinokubakho zempilo yabantu

ushicilelo Imeyli isabelo Ukufuna

(Ukuhlaziywa ngoFebruwari 17, kongeza ukugxeka isifundo)

A iphepha elitsha lezesayensi Ukuvavanya iimpembelelo ezinokubakho kwezempilo zeRoundup herbicides kufumanise unxibelelwano phakathi kokuchasana nokhula olubulala ikhemikhali glyphosate kunye nokonyuka kohlobo lwe-amino acid eyaziwa ngokuba ngumngcipheko wesifo sentliziyo.

Abaphandi benza izigqibo zabo emva kokubhengeza iigundane ezikhulelweyo kunye neentsana zabo ezisandul 'ukuzalwa kwi-glyphosate kunye neRoundup ngamanzi okusela. Bathe bajonge ngokukodwa kwiziphumo ze-glyphosate-based herbicides (GBH) kwiimetabolites zomchamo kunye nokunxibelelana ne-gut microbiome kwizilwanyana.

Abaphandi bathi bafumene ukonyuka okubonakalayo kwe-amino acid ebizwa ngokuba yi-homocysteine ​​kwiintsana zamaduna ezivezwe kwi-glyphosate nakwiRoundup.

"Uphononongo lwethu lubonelela ngobungqina bokuqala bokuba ukubhencwa kwi-GBH esetyenziswa ngokuxhaphakileyo, kumthamo wokubonisa ukubonwa kwabantu okwamkelekileyo okwangoku, kunakho ukuguqula umchamo kwimetabolites kuzo zombini iirati zabantu abadala kunye namantshontsho," utshilo umphandi.

Eli phepha linesihloko esithi “Ukuvezwa kwethamo elisezantsi lokutshabalalisa ukhula lwe-glyphosate-based herbicides kuphazamisa i-metabolism yomchamo kunye nokunxibelelana kwayo ne-gut microbiota,” libhalwe ngabaphandi abahlanu abasebenzisana ne-Icahn School of Medicine kwiNtaba yeSinayi eNew York kunye nezine ezivela eRamazzini Institute eBologna, e-Itali. Yapapashwa kwijenali yeeNgxelo zezeNzululwazi ngoFebruwari 5.

Ababhali bavumile uninzi lwezithintelo kufundo lwabo, kubandakanya nesampulu encinci, kodwa bathi umsebenzi wabo ubonakalisile ukuba "ukubonakaliswa kwethamo eliphantsi kunye nobomi obuncinci kwi-glyphosate okanye iRoundup kutshintshe kakhulu umchamo kwi-biomarker yomchamo, emadamini nakwinzala."

Uphononongo lolokuqala kwiinguqu kwimichamo ye-metabolism ye-urinary eyenziwe yi-glyphosate-based herbicides kwiidosi ekujongwa ukuba zikhuselekile ebantwini, abaphandi bathi.

Eli phepha lilandela ukupapashwa kwinyanga ephelileyo isifundo kwiphephancwadi Imiba yezeMpilo efumene i-glyphosate kunye nemveliso ye-Roundup inokutshintsha ukwakheka kwe-gut microbiome ngeendlela ezinokuthi zinxulunyaniswe neziphumo ezibi zempilo. Inzululwazi ezivela eRamazzini Institute nazo zazibandakanyekile kolo phando.

URobin Mesnage, ongomnye wababhali bephepha elipapashwe kwinyanga ephelileyo kwiiNkqubo zeMpilo yezeNdalo, uthathe umba ngokunyaniseka kwephepha elitsha. Uthe uhlalutyo lwedatha lubonisa iyantlukwano efunyenwe phakathi kwezilwanyana ezivezwe kwi-glyphosate kunye nezo zingatyhilelwanga- izilwanyana ezilawulayo- zinokufunyanwa ngokufanayo nedatha eveliswe ngokungacwangciswanga.

"Ngokubanzi, uhlalutyo lwedatha alusixhasi isigqibo sokuba i-glyphosate iphazamisa umchamo kwimetabolome kunye ne-gut microbiota yezilwanyana eziveziweyo," utshilo uMesnage. "Olu phononongo luya kuphinda luqhubeke ludida nje ingxoxo malunga nobutyhefu be-glyphosate."

Izifundo ezininzi zamva nje kwi-glyphosate kunye ne-Roundup bafumene uluhlu lweenkxalabo.

I-Bayer, eyazuza njenge-Monsanto's glyphosate-based herbicide brand kunye ne-glyphosate-tolerant portal seeded portfolio yayo xa yayithenga inkampani kwi-2018, igcina ukuba ubuninzi besifundo senzululwazi kumashumi eminyaka buqinisekisa ukuba i-glyphosate ayibangeli mhlaza. I-Arhente yokuKhuselwa kokusiNgqongileyo e-US kunye neminye imibutho emininzi yamazwe aphesheya nayo ayithathi njengemveliso ye-glyphosate njenge-carcinogenic.

Kodwa i-Arhente yeHlabathi yezeMpilo yoPhando ngomhlaza kwi-2015 yathi uphononongo lophando lwenzululwazi lufumene ubungqina obaneleyo bokuthi i-glyphosate yinto enokubangela i-carcinogen yabantu.

I-Bayer ilahlekelwe zizilingo ezintathu kwezintathu eziziswe ngabantu abagxeka i-cancer yabo ekuvezeni i-Monsanto's herbicides, kwaye i-Bayer kunyaka ophelileyo ithe izakuhlawula i-11 yezigidigidi zeedola ukuhlawula ngaphezulu kwe-100,000 amabango afanayo.

 

 

Isifundo esitsha sifumana utshintsho olunxulumene ne-glyphosate kwi-gut microbiome

ushicilelo Imeyli isabelo Ukufuna

Isifundo esitsha sezilwanyana liqela labaphandi baseYurophu lifumanise ukuba amanqanaba asezantsi okubulala ukhula kwimichiza ye-glyphosate kunye nemveliso esekwe kwi-glyphosate esekwe kwi-Roundup inokutshintsha ukwakheka kwe-gut microbiome ngeendlela ezinokuthi zinxulunyaniswe neziphumo ezibi zempilo.

Lephepha, ipapashwe ngoLwesithathu kwijenali Imiba yezeMpilo, ibhalwe ngabaphandi abali-13, kuqukwa nophando lukaGqirha Michael Antoniou, intloko yeGene Expression and Therapy Group kwiSebe lezoNyango kunye neMolekyuli yemfuza eKing's College eLondon, kunye noGqirha Robin Mesnage, iqabane lophando kwezobuchwephesha kwezobuchwephetsha ngaphakathi. iqela elinye. Oososayensi abavela kwiZiko iRamazzini e-Bologna, e-Itali, bathathe inxaxheba kolu phando njengoko besenza oososayensi baseFrance nase Netherlands.

Iziphumo ze-glyphosate kwi-gut microbiome zifunyenwe zibangelwa yindlela efanayo yokusebenza ethi glyphosate ibulale ukhula kunye nezinye izityalo, abaphandi bathi.

Iintsholongwane ezisemathunjini omntu zibandakanya iintlobo ngeentlobo zebacteria kunye nefungi echaphazela ukusebenza kwamajoni omzimba kunye nezinye iinkqubo ezibalulekileyo, kunye nokuphazamiseka kwale nkqubo kunokuba negalelo kuluhlu lwezifo, abaphandi bathi.

"Zombini i-glyphosate kunye ne-Roundup ziye zanefuthe kubume bebacterial bacterium," uAntoniou uthethwe ngodliwano-ndlebe. Siyazi ukuba amathumbu ethu ahlala kumawaka eentlobo ezahlukeneyo zeebhaktiriya kunye nokuma kwazo, kwaye kubaluleke ngakumbi ekusebenzeni kwazo, kubalulekile kwimpilo yethu. Ke nantoni na ephazamisayo, ephazamisa kakubi, i-gut microbiome… inokubangela impilo enkenenkene kuba sisuka ekusebenzeni ngokulungeleleneyo okulungeleyo impilo ukuya ekusebenzeni okungalinganiyo okunokukhokelela kwizifo ezahlukeneyo. ”

Jonga udliwanondlebe noCarey Gillam uGqirha Michael Antonoiu kunye noGqr.Robin Mesnage malunga nesifundo sabo esitsha sokujonga ifuthe le-glyphosate kwi-gut microbiome.

Ababhali bephepha elitsha bathi bazimisele ukuba, ngokuchaseneyo nezinye izimvo ngabagxeki bokusetyenziswa kwe-glyphosate, i-glyphosate ayisebenzi njenge -antibiotic, ibulala iintsholongwane eziyimfuneko emathunjini.

Endaweni yoko, bathi-okokuqala, bathi-ukuba iyeza lokubulala izitshabalalisi laphazamisa ngendlela enokubangela inkxalabo ye-biochemical pathway ye-gut gut bacteria yezilwanyana ezisetyenziswe kulingo. Olo phazamiso lwabonakaliswa lutshintsho kwizinto ezithile emathunjini. Uhlalutyo lwamathumbu kunye ne-biochemistry yegazi luveze ubungqina bokuba izilwanyana ziphantsi koxinzelelo lwe-oxidative, imeko ehambelana nomonakalo we-DNA kunye nomhlaza.

Abaphandi bathi akucaci ukuba ukuphazamiseka ngaphakathi kwangaphakathi kwe-microbiome kuthinte uxinzelelo lwe-metabolic.

Ukubonakaliswa koxinzelelo lwe-oxidative kwabonakala ngakumbi kuvavanyo kusetyenziswa i-glyphosate-based herbicide ebizwa ngokuba yiRoundup BioFlow, imveliso yomnini weMonsanto uBayer AG, izazinzulu zatsho.

Ababhali bokufunda bathi baqhuba izifundo ezininzi ukuzama ukucacisa ukuba uxinzelelo lwe-oxidative abalubonayo luyonakalisa ne-DNA, eya kuphakamisa umngcipheko womhlaza.

Ababhali bathi uphando oluthe kratya luyafuneka ukuze kuqondwe ngokwenyani imeko yezempilo ye-glyphosate inhibition yendlela ebukekayo kunye nolunye uphazamiseko kwimetro microbiome nasegazini kodwa iziphumo zokuqala zinokusetyenziswa kuphuhliso lweempawu ze-bio zophando lwezifo kunye nokuqonda ukuba i-glyphosate herbicides inokuba neziphumo zebhayiloji ebantwini.

Kwisifundo, iigundane zabasetyhini zanikwa i-glyphosate kunye nemveliso yeRoundup. Iidosi zisiwe ngamanzi okusela anikezelwa kwizilwanyana kwaye zanikwa kumanqanaba abonisa ukufakwa okwamkelekileyo kwemihla ngemihla kuthathwa njengokukhuselekileyo ngabalawuli baseYurophu naseMelika.

U-Antoniou uthe iziphumo zophando zakha kolunye uphando olwenza ukuba kucace ukuba abalawuli baxhomekeke kwiindlela eziphelelwe lixesha xa kusenziwa isigqibo ngamanqanaba "akhuselekileyo" e-glyphosate kunye nezinye izibulala-zinambuzane ekutyeni nasemanzini. Iintsalela zamayeza okubulala izitshabalalisi ezisetyenziswa kwezolimo zihlala zifumaneka kuluhlu lokutya okutyiwa rhoqo.

"Abalawuli kufuneka bangene kwinkulungwane yamashumi amabini ananye, bayeke ukurhuqa iinyawo zabo ... kwaye bamkele iintlobo zohlalutyo esele sizenzile kolu phando," utshilo u-Antoniou. Uthe ukuprofeta kwemolekyuli, yinxalenye yesebe lezesayensi eyaziwa ngokuba yi "OMICS," Uguqula isiseko solwazi malunga nefuthe lokuchazwa kwemichiza kwezempilo.

Uphononongo lweerat kodwa lolutshanje kuthotho lwezilingo zesayensi ezijolise ekuqinisekiseni ukuba ngaba i-glyphosate kunye ne-glyphosate-based herbicides- kubandakanya iRoundup- inokuba yingozi ebantwini, nakumanqanaba abalawuli bokubhengeza bathi bakhuselekile.

Izifundo ezininzi ezinjalo zifumene uluhlu lweenkxalabo, kubandakanya epapashwe ngoNovemba  ngabaphandi abavela kwiDyunivesithi yaseTurku eFinland abathi babenakho ukufumanisa, "kuqikelelo olulondolozayo," ukuba malunga neepesenti ezingama-54 zeentlobo zezinto ezisembindini wegciwane lomntu emathunjini "zinokuthamba" kwi-glyphosate.

Njengabaphandi baya besanda jonga ukuqonda i-microbiome yomntu kunye nendima ayidlalayo kwimpilo yethu, imibuzo malunga nefuthe elinokubakho le-glyphosate kwi-gut microbiome khange ibe yingxoxo nje kuphela kwizangqa zesayensi, kodwa nakwizimangalo.

Kunyaka ophelileyo, iBayer uvumile ukuhlawula i-39.5 yezigidi zeedola ukulungisa amabango athi iMonsanto yaqhuba intengiso elahlekisayo ibanga ukuba i-glyphosate yenze kuphela i-enzyme kwizityalo kwaye ayinakuba nefuthe kwizilwanyana nakwabantu. Abamangali kwimeko etyholwa ukuba i-glyphosate ijolise kwi-enzyme efumaneka ebantwini nakwizilwanyana ezomeleza amajoni omzimba, ukwetyisa kunye nokusebenza kwengqondo.

I-Bayer, eyazuza njenge-Monsanto's glyphosate-based herbicide brand kunye ne-glyphosate-tolerant portal seeded portfolio yayo xa yayithenga inkampani kwi-2018, igcina ukuba ubuninzi besifundo senzululwazi kumashumi eminyaka buqinisekisa ukuba i-glyphosate ayibangeli mhlaza. I-Arhente yokuKhuselwa kokusiNgqongileyo e-US kunye neminye imibutho emininzi yamazwe aphesheya nayo ayithathi njengemveliso ye-glyphosate njenge-carcinogenic.

Kodwa i-Arhente yeHlabathi yezeMpilo yoPhando ngomhlaza kwi-2015 yathi uphononongo lophando lwenzululwazi lufumene ubungqina obaneleyo bokuthi i-glyphosate yinto enokubangela i-carcinogen yabantu.

Ukusukela ngelo xesha, iBayer ilahlekelwe zizilingo ezintathu kwezintathu eziziswe ngabantu abagxeka umhlaza wabo ekuvezeni i-Monsanto's herbicides, kwaye iBayer kunyaka ophelileyo ithe izakuhlawula i-11 yezigidigidi zeedola ukuhlawula ngaphezulu kwe-100,000 amabango afanayo.