Uphando olutsha longeza ubungqina bokuba ukhula olubulala ukhula luyaphazamisa iihormoni

ushicilelo Imeyli isabelo Ukufuna

Uphando olutsha longeza ubungqina obukhathazayo kwinkxalabo yokuba ukubulala ukhula kusetyenziswa kakhulu imichiza glyphosate inokubanakho ukuphazamisa iihomoni zabantu.

Kwiphepha elipapashwe kwijenali Imichiza zibizwa IGlyphosate kunye neempawu eziphambili zokuphazamiseka kwe-endocrine: Uphengululo, Isithathu senzululwazi sagqiba kwelokuba i-glyphosate ibonakala ineempawu ezisibhozo kwezilishumi eziphambili ezinxulunyaniswa i-endocrine ephazamisa iikhemikhali . Ababhali balumkisile, nangona kunjalo, ukuba izifundo eziza kudibana ziyafuneka ukuze kuqondwe ngokucacileyo iimpembelelo ze-glyphosate kwinkqubo ye-endocrine yomntu.

Ababhali, uJuan Munoz, uTammy Bleak noGloria Calaf, elowo nalowo unxulumene neYunivesithi yaseTarapacá eChile, bathi iphepha labo luphononongo lokuqala lokudibanisa ubungqina boomatshini kwi-glyphosate njenge-endocrine-disrupting chemical (EDC).

Obunye bobungqina bucacisa ukuba iRoundup, eyaziwa ngokuba yi-glyphosate-based herbicide, inokutshintsha i-biosynthesis yehomoni zesondo, ngokutsho kwabaphandi.

Ii-EDCs zinokulingisa okanye ziphazamise iihomoni zomzimba kwaye zinxulunyaniswa nengxaki zokukhula kunye nokuzala kunye nengqondo kunye nokungasebenzi komzimba.

Eli phepha litsha lilandela ukupapashwa ebutsheni balo nyaka Uluhlu lwezifundo zezilwanyana ebonakalise ukuvezwa kwe-glyphosate kuchaphazela amalungu okuzala kwaye isoyikisa ukuzala.

IGlyphosate sesona sifo sisetyenziswa kakhulu emhlabeni, esithengiswa kumazwe ali-140. Yaziswa ngentengiso ngo-1974 nguMonsanto Co, imichiza sisithako esisebenzayo kwiimveliso ezithandwayo ezinje ngeRoundup kunye namakhulu abanye babulali bokhula abasetyenziswa ngabathengi, oomasipala, izixhobo, amafama, abaqhubi begalufa kunye nabanye kwihlabathi liphela.

UDana Barr, Unjingalwazi kwiYunivesithi yaseEmory iRollins School of Health Public, wathi obu bungqina “buye bubonakalise ngendlela engathethekiyo ukuba i-glyphosate ine-endocrine ephazamisa iipropathi.”

“Ayisiyonto ingalindelekanga kuba i-glyphosate inezakhiwo ezifanayo nezinye i-endocrine ephazamisa ukubulala izinambuzane; Nangona kunjalo, ingakumbi kuba ukusetyenziswa kwe-glyphosate kudlula kude ezinye izibulali zinambuzane, ”utshilo u-Barr, olawula inkqubo ngaphakathi kwiziko le-National Institutes of Health elixhaswa ngezempilo. "IGlyphosate isetyenziswa kwizityalo ezininzi nakwizicelo ezininzi zokuhlala ezinokubangela ukubonwa kwabantu ngokubanzi."

Phil Landrigan, umlawuli we-Global Observatory on Pollution and Health, kunye nonjingalwazi webhayoloji
KwiKholeji yaseBoston, uthe uphononongo ludibanise "ubungqina obuqinileyo" bokuthi i-glyphosate ngumphazamisi we-endocrine.

"Ingxelo iyahambelana nomzimba omkhulu woncwadi obonisa ukuba i-glyphosate inoluhlu olubanzi lweziphumo ezibi kwezempilo - iziphumo eziguqula imeko ende kaMonsanto ukuvezwa kwe-glyphosate njengekhemikhali enobungozi engenazimpembelelo zimbi kwimpilo yabantu, ”utshilo uLandrigan.

Ii-EDC bezingumbandela oxhalabisayo ukusukela nge-1990s emva kothotho lopapasho olucebisayo ukuba ezinye iikhemikhali zisetyenziswa kakhulu kwizibulali zinambuzane, izinyibilikisi zorhwebo, iiplastikhi, iisepha, kunye nezinye izinto zinokubanakho ukuphazamisa unxibelelwano phakathi kwamahomoni kunye nezamkeli.

Izazinzulu ngokubanzi ziye zamkela iipropathi ezilishumi ezisebenzayo zearhente eziguqula isenzo sehomoni, zibhekisa kwezi "njengeempawu eziphambili" ezilishumi ze-endocrine-disorors. Iimpawu ezilishumi zezi zilandelayo:

Ii-EDC's zinako:

  • Ukutshintsha kwehomoni ukuhanjiswa kwamanqanaba okujikeleza kwehomoni
  • Yenza utshintsho kwi-hormone metabolism okanye kugqitywe
  • Guqula ikamva lokuvelisa iincindi zamadlala okanye iiseli eziphendula iihomoni
  • I-Alter hormone receptor expression
  • Ukuchasene ne-hormone receptors
  • Nxibelelana okanye wenze ii-hormone receptors
  • Ukutshintshwa kwesiginali yokutshintsha kwiiseli eziphendula ihomoni
  • Yenza uhlengahlengiso lwe-epigenetic kwimveliso evelisa iihomoni okanye iiseli eziphendula ihomoni
  • Alter hormone synthesis
  • Utshintsho lwehormoni yokuhambisa kwiimbrane zeseli

Ababhali bephepha elitsha bathi uphononongo lwedatha yoomatshini lubonise ukuba i-glyphosate idibene nazo zonke iimpawu eziphambili ngaphandle kwezi zimbini: "Ngokubhekiselele kwi-glyphosate, abukho ubungqina obunxulunyaniswa namandla okuchasana nabamkeli behomoni," batsho. Kananjalo, "abukho ubungqina bempembelelo yayo kwimetabolism ye-hormonal okanye kugqitywe," ngokutsho kwababhali.

Uphando kule minyaka ingamashumi idlulileyo lujolise ikakhulu kumakhonkco afunyanwa phakathi kwe-glyphosate kunye nomhlaza, ngakumbi i-non-Hodgkin lymphoma (NHL.) Ngo-2015, i-Arhente yeHlabathi yezeMpilo yoPhando ngomhlaza. I-glyphosate echaziweyo njenge-carcinogen yabantu.

Bangaphezu kwe-100,000 abantu Ndimangalele uMonsanto e-United States etyhola ukubhencwa kwimichiza yokubulala ukhula eglyphosate esekwe kwinkampani kubangele bona okanye abo babathandayo ukuba baphuhlise i-NHL.

Abamangali kwizimangalo zelizwe lonke bathi iMonsanto kudala ifuna ukufihla umngcipheko weyeza layo. IMonsanto ilahlekelwe zizilingo ezintathu kwezintathu kwaye umnini wayo waseJamani uBayer AG uchithe unyaka ophelileyo enesiqingatha ukuzama ukuhlala Ukumangalelwa ngaphandle kwenkundla.

Ababhali bephepha elitsha baqaphela indalo ekuyo yonke indawo ye-glyphosate, besithi "ukusetyenziswa okukhulu" kwale khemikhali "kukhokelele ekusasazekeni kwendalo," kubandakanya nokuvela okuchaphazelayo okuboshwe kukusetyenziswa kwabantu kombulali wokhula ngokutya.

Abaphandi bathi nangona abalawuli bathi amanqanaba entsalela ye-glyphosate efumaneka ekutyeni iphantsi ngokwaneleyo ukuba ikhuseleke, "abanakuyilawula" ingozi "enokubakho ebantwini abatya ukutya okungcoliswe yimichiza, ngakumbi iinkozo kunye nezinye izityalo- ukutya okusekwe, okuhlala kunamanqanaba aphezulu kunobisi, inyama okanye iimveliso zentlanzi.

Amaxwebhu aseburhulumenteni ase-US abonisa ukuba iintsalela ze-glyphosate zifunyenwe kuluhlu lokutya, kubandakanya ubusi bendalo, yaye igranola kunye nabaqhekezi.

Abaphandi bakarhulumente waseCanada bakwachaze intsalela yeglyphosate ekutyeni. Ingxelo enye ekhutshwe ngo-2019 ngoososayensi abavela kwiiLabhoratri zeAgri-Food eCanada e-Alberta Ministry of Agriculture and Forestry bafumana i-glyphosate kwi-197 ye-200 yeesampulu zobusi abazihlolisayo.

Ngaphandle kwenkxalabo malunga nefuthe le-glyphosate kwimpilo yabantu, kubandakanya nokuvezwa kokutya, abalawuli base-US bakhusele ngokuqinileyo ukhuseleko lweekhemikhali. Inkqubo ye- I-Arhente yokuKhuselwa kokusiNgqongileyo igcina ayifumanekanga "nayiphi na impilo yomntu ngenxa yokuchanabeka kwi-glyphosate. ”