Iidasethi eziguqulweyo ziphakamisa imibuzo ethembekileyo malunga nezifundo eziphambili kwimvelaphi yecoronavirus

ushicilelo Imeyli isabelo Ukufuna

Uhlaziyo lwedatha ye-genomic enxulumene nezifundo ezine eziphambili kwimvelaphi ye-coronavirus yongeza eminye imibuzo malunga nokuthembeka kwezi zifundo, ezibonelela ngenkxaso esisiseko ye-hypothesis ukuba i-SARS-CoV-2 ivela kwizilwanyana zasendle. Izifundo, UPeng Zhou et al., Hong Zhou okqhubekayo., Lam kunye al., yaye Xiao okqhubekayo., Ufumanise ii-coronaviruses ezinxulumene ne-SARS-CoV-2 kumalulwane amahashe kunye neepangolins zaseMalayan.

Ababhali bezifundo bafaka idatha yokulandelelana kweDNA ebizwa ngokuba ngokulandelelana kufundwa, ababeyisebenzisela ukudibanisa i-bat- kunye ne-pangolin-coronavirus genomes, kwiZiko leSizwe loLwazi lwe-Biotechnology (NCBI) ngokulandelelana funda indawo yokugcina (SRA). I-NCBI iseke ugcino lwedatha yoluntu ukunceda ukungqinisisa okuzimeleyo kohlalutyo lwe-genomic ngokusekwe kubuchwephesha bokulandelelana okuphezulu.

Ilungelo lase-US lokuFumana amaxwebhu ngokwenziwa kweerekhodi zikarhulumente ukuba bonisa uhlaziyo kwezi zifundo 'i-SRA yedatha yeenyanga emva kokuba zipapashiwe. Olu hlaziyo aluqhelekanga kuba lwenzekile emva kokupapashwa, kwaye ngaphandle kwesizathu, inkcazo okanye ukuqinisekiswa.

Umzekelo, UPeng Zhou et al. kwaye Lam kunye al. bahlaziya idatha yabo ye-SRA ngemihla emibini efanayo. La maxwebhu awachazi ukuba kutheni etshintshe idatha, kuphela ukuba kwenziwe utshintsho oluthile. Xiao okqhubekayo. benze utshintsho oluninzi kwidatha yabo ye-SRA, kubandakanya nokususwa kweedatha ezimbini ngo-Matshi 10, ukongezwa kwedatha entsha ngoJuni 19, ukutshintshwa kwedatha ngoNovemba 8 kwedatha yokuqala eyakhutshwa ngo-Okthobha u-30, kunye nolunye utshintsho lwedatha ngo-Novemba 13- kwiintsuku ezimbini emva koko indalo yongeze "inqaku lenkxalabo" loMhleli malunga nesifundo. Hong Zhou okqhubekayo. awusabelani ngedatha epheleleyo ye-SRA eya kwenza ukuba uqinisekiso luzimele. Ngelixa iijenali zithanda indalo ifuna ababhali ukuba benze yonke idatha "ifumaneke ngokukhawuleza”Ngexesha lokupapashwa, idatha ye-SRA inokukhutshwa emva upapasho; kodwa ayiqhelekanga ukwenza olo tshintsho kwiinyanga emva kokupapashwa.

Olu tshintsho lungaqhelekanga kwidatha ye-SRA alwenzi ngokuzenzekelayo ukuba ezi zifundo zine kunye needatha zazo ezinxulumene nazo zingathembeki. Nangona kunjalo, ukulibaziseka, izithuba kunye notshintsho kwidatha ye-SRA Indibano ezimeleyo kunye nokuqinisekiswa yokulandelelana kwe-genome ngokulandelelana, kwaye yongeza ku imiba kwaye xhalaba malunga le sekile kwezi zifundo zine, ezinje:

  1. Luluphi olona hlaziyo lwasemva kokupapashwa kwedatha ye-SRA? Zazenzelwe ntoni? Ziluchaphazele njani uhlalutyo oluhambelana nolwe-genomic kunye neziphumo?
  2. Ngaba oku kuhlaziywa kwe-SRA kuqinisekiswe ngokuzimeleyo? Ukuba kunjalo, njani? Inkqubo ye- Ukuqinisekiswa kweNCBI kuphela Indlela yokushicilela iSRA BioProject- ngaphaya kolwazi olusisiseko oluthi "igama lomzimba" - kukuba ayinakuphindwa.

Ngolunye ulwazi: 

The IZiko leLizwe leNkcazelo yeBiotechnology (NCBI) amaxwebhu anokufunyanwa apha: Ii-imeyile zeNCBI (Iphepha le-63)

Ilungelo lase-US lokwazi ukuthumela amaxwebhu avela kwizicelo zethu zeerekhodi zoluntu zophando lwethu lwee-biohazards. Bona: Amaxwebhu e-FOI kwimvelaphi ye-SARS-CoV-2, iingozi zokufumana umsebenzi kunye neelebhu zokutya.

Iphepha elingasemva kuphando lwase-US lweLungelo lokwazi ngemvelaphi ye-SARS-CoV-2.