Monsanto’s campaign against U.S. Right to Know: key themes and documents

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Internal Monsanto documents released in August 2019 via litigation describe Monsanto’s campaign to counter a U.S. Right to Know investigation into its business and ties between the company and public university professors. USRTK has made public records requests to taxpayer-funded universities since 2015, leading to revelations about secretive industry collaborations with academics. (See USRTK Investigations.)

The documents show that Monsanto was worried the public records requests had the “potential to be extremely damaging” and so crafted plans to counter the USRTK investigation that involved 11 Monsanto employees, three industry staffers and two PR firms. The documents also show that Monsanto adopted a strategy to counter the reporting of Carey Gillam and her investigative book about the company’s herbicide business. Gillam is the research director of U.S. Right to Know.  

“Monsanto had a ‘Carey Gillam Book’ spreadsheet, with more than 20 actions dedicated to opposing her book before its publication, including working to ‘Engage Pro-Science Third Parties’ in criticisms, and partnering with ‘SEO experts’ to spread its attacks,” reported Sam Levin in the Guardian. See:

The newly released documents provide a rare look into the public relations machinery at Monsanto, and how it tried to contain an investigation into its relationships with academics and third parties who have promoted the company’s agenda.

Key themes in the newly released Monsanto documents

Monsanto was deeply worried about USRTK Co-director Gary Ruskin’s FOIA investigation, and had an elaborate plan to counteract it. 

Monsanto was concerned that the FOIAs would uncover its influence in the regulatory and policy process, payments to academics and their universities, and collaborations with academics in support of industry public relations goals. Monsanto wanted to protect its reputation and “freedom to operate,” and to “position” the investigation as “an attack on scientific integrity and academic freedom.”

  • “USRTK’s plan will impact the entire industry, and we will need to coordinate closely with BIO and CBI/GMOA throughout the planning process and on any eventual responses,” according to Monsanto’s “U.S. Right to Know FOIA Communications Plan” dated July 25, 2019. BIO is the biotech industry trade association and Council for Biotechnology Information/GMO Answers is a marketing program to promote GMOs run by Ketchum PR firm and funded by the largest agrichemical companies – BASF, Bayer (which now owns Monsanto), Corteva (a division of DowDuPont) and Syngenta.

The companies have pitched GMO Answers as a transparency initiative  to answer questions about GMOs with the voices of “independent experts,” however the documents described here, along with a previously released Monsanto PR plan, suggest that Monsanto relies on GMO Answers as a vehicle to push the company’s messaging.

From page 2, “Monsanto Company Confidential … U.S. Right to Know FOIA Communications Plan

  • “Any situation related to this issue has the potential to be extremely damaging, regardless of how benign the information may seem,” according to a GMO Answers Communications Plan in the document (page 23).

  • “*Worst case scenario*”: “Egregious email illustrates what would be the smoking gun of the industry (e.g. email shows expert/company covering up unflattering research or showing GMOs are dangerous/harmful)” (page 26)

  • The plan called for triggering “emergency calls” with the GMO Answers steering committee if the reach/escalation were serious enough. (page 23)
  • In some cases, Monsanto employees expected access to documents before U.S. Right to Know, even though USRTK requested the documents through state FOI. For UC Davis requests: “We will have a pre-release view of documents”. (page 3)
  • 11 Monsanto employees from 5 departments; two staffers from the trade group BIO and a staffer from GMO Answers/Ketchum were listed as “key contacts” in the plan (page 4). Two employees from FleishmanHillard were involved in assembling the plan (see agenda email).

Monsanto was also concerned about Carey Gillam’s book and tried to discredit it.

Several of the newly released documents relate to Monsanto’s efforts to counteract the reporting of Carey Gillam and her book that investigates the company’s herbicide business: “Whitewash: The Story of a Weed Killer, Cancer and the Corruption of Science” (Island Press, 2017). Gillam is a former reporter for Reuters and current research director of U.S. Right to Know.

The documents include Monsanto’s  20-page “Issues Management / Communication Strategy” for Gillam’s book, with eight Monsanto staffers assigned to preparing for the October 2017 release of Gillam’s book. The strategy was to “minimize media coverage and publicity of this book this summer/fall by pointing to “truths” regarding farming …” 

An Excel spreadsheet titled “Project Spruce: Carey Gillam Book” describes 20 action items, with plans including paid placement for a post to appear on Google with a search for “Monsanto glyphosate Carey Gillam,” generating negative book reviews, and plans to “engage regulatory authorities” and “Pro-Science Third Parties,” including Sense About Science, Science Media Centre, the Global Farmer Network and the “Campaign for Accuracy in Public Health Research,” a project of the American Chemistry Council.

The documents reveal the existence of the Monsanto Corporate Engagement Fusion Center. 

Monsanto planned to “Work with the Fusion Center to monitor USRTK digital properties, the volume and sentiment related to USRTK/FOIA, as well as audience engagement.” (page 9) For more about corporate fusion centers, see:

Monsanto makes frequent references to working with third parties to counteract USRTK.

Others mentioned in the plans included:

Newly released documents list

Monsanto’s campaign to counteract the U.S. Right to Know public records investigation

Monsanto U.S. Right to Know FOIA Communications Plan 2019
July 25, 2019: Monsanto’s 31-page strategy plan to counteract the FOIA investigation. “USRTK’s plan will impact the entire industry…. Any situation related to this issue has the potential to be extremely damaging…”

Monsanto USRTK FOIA meeting agenda
May 15, 2016: Agenda for a meeting to discuss the USRTK FOIAs with eight Monsanto and two FTI Consulting employees.

Monsanto Comprehensive USRTK FOIA Preparedness and Reactive Plan 2016
May 15, 2016: Earlier draft of the Monsanto strategy to deal with the FOIAs (35 pages).

Monsanto response to FOIA article
February 1, 2016: Monsanto employees crafted a communications plan to provide a “10,000 foot view” of how Monsanto works with public sector scientists and/or provides funding to public sector programs – but not details about which universities they fund or how much. The plan responded to an article Carey Gillam wrote for USRTK, based on documents obtained by FOIA, reporting on undisclosed Monsanto funding to University of Illinois Professor Bruce Chassy.

Unfortunate language AgBioChatter Biofortified boys

  • September 2015: Discussion about “unfortunate” language used by an industry representative to communicate with academics and whether AgBioChatter, a list serve of academics and industry reps, was private or confidential. Karl Haro von Mogel of the GMO promotion group Biofortified advised AgBioChatter members to take “the Ruskin Cleanse” of their private emails to prevent damaging disclosures via FOIA.
  • Bruce Chassy shared with the AgBioChatter list his responses to a fact checker for Mother Jones (“I plan to respond without providing the requested information”) and his correspondence with Carey Gillam in response to her queries for Reuters about his industry ties.

Monsanto’s plans to discredit Carey Gillam’s Book

“Monsanto Company Confidential Issues Management / Communication Strategy” for Carey Gillam’s Book (October 2017)

“Project Spruce: Carey Gillam Book” Excel spreadsheet with 20 action items (September 11, 2017)

Monsanto and FTI Consulting employees discuss the Gillam action plan (September 11, 2017)

Monsanto video prep plans for Gillam book

Monsanto push back on Reuters editors
October 1, 2015: Email from Monsanto’s Sam Murphey: “We continue to push back on her editors very strongly every chance we get. And we all hope for the day she gets reassigned.”

Roundup “Reputation Management”

Reputation Management for Roundup 2014
February 2014: “L&G Reputation Management Sessions Summary, Lyon Feb. 2014” Power Point, with slides that describe what “we want to be known for / we want to avoid being linked with,” and what’s needed to win the argument about glyphosate safety.  “Question… are we just managing and delaying decline (like tobacco)?”

Roundup reputation management slide 2014:

Background on U.S. Right to Know investigations

U.S. Right to Know is a non-profit investigative research group focused on the food industry. Since 2015, we have obtained hundreds of thousands of pages of corporate and regulatory documents via Freedom of Information Act (FOIA), U.S. state and international public records requests, and whistleblowers. These documents shine light on how food and agrichemical companies work behind the scenes with publicly funded academics and universities, front groups, regulatory agencies and other third party allies to promote their products and lobby for deregulation.

News coverage based on documents from USRTK Co-director Gary Ruskin’s investigation of the agrichemical industry:

    • New York Times: Food Industry Enlisted Academics in G.M.O. Lobbying War, Emails Show, by Eric Lipton
    • Boston Globe: Harvard Professor Failed to Disclose Connection, by Laura Krantz
    • The Guardian: UN/WHO Panel in Conflict of Interest Row over Glyphosate Cancer Risk, by Arthur Neslen
    • CBC: University of Saskatchewan Prof Under Fire for Monsanto Ties, by Jason Warick
    • CBC: U of S Defends Prof’s Monsanto Ties, But Some Faculty Disagree, by Jason Warick
    • Mother Jones: These Emails Show Monsanto Leaning on Professors to Fight the GMO PR War, by Tom Philpott
    • Global News: Documents Reveal Canadian Teenager Target of GMO Lobby, by Allison Vuchnich
    • Le Monde: La discrète influence de Monsanto, by Stéphane Foucart.
    • The Progressive: Flacking for GMOs: How the Biotech Industry Cultivates Positive Media — and Discourages Criticism, by Paul Thacker
    • Freedom of the Press Foundation: How corporations suppress disclosure of public records about themselves, by Camille Fassett
    • WBEZ: Why Didn’t an Illinois Professor Have to Disclose GMO Funding?, by Monica Eng
    • Saskatoon Star Phoenix: Group Questions U of S Prof’s Monsanto Link, by Jason Warick

For more information about the U.S. Right to Know documents, see our investigations page, examples of global news coverage and academic papers based on the documents. Many of the documents are posted in the free, searchable UCSF Industry Documents Library.

Donate to USRTK to help us expand our investigations and keep bringing you this crucial information about our food system. USRTK.org/donate

Nina Fedoroff: Mobilizing the authority of American science to back Monsanto

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Key points:

  • As a president and board chair of AAAS from 2011-2013, Dr. Fedoroff advanced agrichemical industry policy objectives. She now works for a lobbying firm.
  • Documents obtained by U.S. Right to Know show how public relations and lobbying efforts are coordinated behind the scenes among the agrichemical industry, front groups and academics who appear independent.
  • Dr. Fedoroff promotes organizations that mislead the public about science and their industry ties.

Nina Fedoroff, PhD, is one of the most influential scientists advocating for the proliferation and deregulation of genetically engineered foods. She is a former president of the American Association for the Advancement of Science (2011-2012) and former chair of the AAAS Board of Directors (2012-2013). She is a senior science advisor since 2015 at OFW Law, a lobbying firm whose clients have included Syngenta and the Council for Biotechnology Information, a trade group representing Bayer (which owns Monsanto), BASF, Corteva (a division of DowDuPont) and Syngenta.

From 2007-2010, Dr. Fedoroff served as science and technology advisor to the Secretary of State and the Administrator of USAID under the George W. Bush and Obama administrations. Prior to that, she was a board member of the Sigma-Aldrich Corporation, a multinational chemical and biotech firm; and an advisory board member of Evogene, a biotechnology company that partnered with DuPont, Syngenta, Bayer and Monsanto. 

In 2017, Dr. Fedoroff promoted the American Council on Science and Health “junk science” book alongside two scientists affiliated with groups that deny climate science and lobby for tobacco products.

As Secretary of State Hillary Clinton’s “science czar,” Dr. Fedoroff served as diplomat for the “GMO all the way” thrust of U.S. foreign policy, Tom Philpott reported in Grist in 2008 and 2009. Pesticide Action Network of North America has described Dr. Fedoroff as “literally the U.S. ambassador” for genetic engineering. According to Greenpeace, Dr. Fedoroff has been “a fervent advocate for the global proliferation of GM (genetically modified) foods throughout her career.”

During her tenure as president and chairman of AAAS, the world’s largest multidisciplinary scientific society, Dr. Fedoroff leveraged those roles to provide political aid to the agrichemical industry: the AAAS Board of Directors under her chairmanship issued a politically timed statement to oppose GMO labeling in 2012; while president of the scientific organization in 2011, Dr. Fedoroff helped defeat a U.S. EPA proposal that would have required additional health and safety data for GMO crops, according to emails described below. See, Nina Fedoroff, AAAS and the agrichemical industry lobby. Dr. Fedoroff and AAAS have not responded to requests for response.

Affiliations with deceptive industry front groups and PR efforts

Dr. Fedoroff has promoted and helped to legitimize groups that claim to be independent voices for science but work behind the scenes with the agrichemical industry in ways that mislead the public − including two groups that helped Monsanto try to discredit the scientists who served on the World Health Organization’s International Agency for Research on Cancer (IARC) expert panel that classified glyphosate as a probable human carcinogen in 2015.

American Council on Science and Health (ACSH) is funded by chemical, pharmaceutical and tobacco companies, according to leaked internal documents that document how the group pitches its services to corporations for product-defense campaigns. Emails released via court proceedings show that Monsanto agreed to fund ACSH in 2015, and asked the group to write about the IARC cancer report on glyphosate; ACSH later claimed the cancer report was a “scientific fraud.”     

Dr. Fedoroff helped promote this group as a legitimate science source in a 2017 National Press Club event to launch the ACSH’s “Little Black Book of Junk Science.” Appearing alongside Dr. Fedoroff at the press event were two scientists affiliated with groups that deny climate science and lobby for tobacco products:

Genetic Literacy Project: Dr. Fedoroff is listed as a board member on the website of the Genetic Literacy Project, a group that claims to be independent but partners with Monsanto on PR and lobbying projects, according to documents obtained by U.S. Right to Know. Documents released in court filings show that Monsanto listed this group among the “industry partners” it planned to engage in a strategy to “orchestrate outcry” against IARC’s glyphosate assessment in order to “protect the reputation and FTO of Roundup.” Genetic Literacy Project has since posted more than 200 articles critical of the cancer research agency, including numerous personal attacks on the scientists involved in the glyphosate report, accusing them of conspiracy, fraud, lying, corruption, secrecy, and being motivated by “profit and vanity.”

In an award-winning series in Le Monde about Monsanto’s “effort to destroy the UN cancer agency by any means possible,” journalists Stéphane Foucart and Stéphane Horel described Genetic Literacy Project and ACSH as “well-known propaganda websites” and said GLP is “fed by PR people linked to the pesticides and biotechnology industries.” GLP was launched in 2011 by Jon Entine, who owns a public relations firm that had Monsanto as a client at that time.

Attacks on cancer researchers on the Genetic Literacy Project website that lists Dr. Fedoroff as a “board member”:

Academics Review: Dr. Fedoroff promoted Academics Review as a trustworthy science source in a 2012 article in Trends in Genetics and a 2016 interview with the Washington Examiner about poor science journalism. Documents obtained by U.S. Right to Know show that Academics Review was set up as a front group with the help of Monsanto to discredit critics of genetic engineering and pesticides, while keeping corporate fingerprints hidden. The group, which claimed to be independent but was funded by agrichemical companies, attacked the organic industry as a “marketing scam.”

Biotech Literacy Boot Camp: Dr. Fedoroff was listed as a core faculty member of a Biotech Literacy Project “boot camp” held at UC Davis in 2015. The event was organized by two PR groups, Genetic Literacy Project and Academics Review, and secretly funded by agrichemical companies to “train scientists and journalists to frame the debate over GMOs and the toxicity of glyphosate,” reported Paul Thacker in The Progressive. Speakers included a familiar list of industry PR allies including Jay Byrne, Jon Entine, Bruce Chassy, David Tribe, Hank Campbell of ACSH and a keynote by the “Sci Babe.”

AgBioWorld: In her 2012 Trends and Genetics article, Dr. Fedoroff promoted the website AgBioWorld as “another invaluable resource” to learn about science. In a 2002 article in the Guardian, George Monbiot described how Monsanto’s PR team used the AgBioWorld website and fake social media accounts to discredit scientists and environmentalists who raised concerns about GM crops. Monbiot reported:  

“At the end of last year, Jay Byrne, formerly [Monsanto’s] director of internet outreach, explained to a number of other firms the tactics he had used at Monsanto. He showed how, before he got to work, the top GM sites listed by an internet search engine were all critical of the technology. Following his intervention, the top sites were all supportive ones (four of them established by Monsanto’s PR firm Bivings). He told them to ‘think of the internet as a weapon on the table. Either you pick it up or your competitor does, but somebody is going to get killed.’

While he was working for Monsanto, Byrne told the internet newsletter Wow that he ‘spends his time and effort participating’ in web discussions about biotech. He singled out the site AgBioWorld, where he ‘ensures his company gets proper play.’ AgBioWorld is the site on which [fake online personality Mary] Smetacek launched her campaign.”

Attack on Greenpeace: Dr. Fedoroff spoke at a 2016 press event for a group calling itself “Support Precision Agriculture,” which presented a letter signed by over 100 Nobel laureates criticizing Greenpeace for their opposition to GMOs. Agrichemical industry allies helped out with the campaign, including Monsanto’s former Communications Director Jay Byrne; former biotech trade group VP Val Giddings; and Matt Winkler, who funds the PR group Genetic Literacy Project and is listed as a board member along with Dr. Fedoroff on the group’s website. The .com version of the supposedly independent “Support Precision Agriculture” website redirected to the Genetic Literacy Project for years (it was delinked after we called attention to it in 2019). In emails from 2011, Byrne identified Greenpeace on a “targets” list he was developing for Monsanto with names of industry critics they could confront from behind the cover of an industry-funded academic group that appeared independent.

Friend of GMO Answers: Dr. Fedoroff is an independent expert for GMO Answers, a PR campaign developed by Ketchum public relations, which has a history of using deceptive tactics to influence the public. Although Ketchum claimed the GMO Answers campaign would “redefine transparency,” the group scripted answers for an “independent” expert and was listed among the “industry partners” in Monsanto’s PR plan to protect Roundup from cancer concerns. A “resources” section (page 4) pointed to GMO Answers and Monsanto links that communicate the company message that “Glyphosate is not carcinogenic.” In 2016, Dr. Fedoroff spoke on a panel sponsored by GMO Answers, Scientific American and the Cornell Alliance for Science about media coverage of science featuring industry-friendly journalists Keith Kloor and Tamar Haspel. See “Monsanto’s Media Machine Comes to Washington,” by Paul Thacker.

Opposed investigation to uncover industry-academic ties

In 2015, Dr. Fedoroff and two other former AAAS presidents, Peter Raven and Phillip Sharp, promoted their AAAS leadership roles, but failed to disclose any of their industry ties, in a Guardian op-ed opposing a public records investigation that sought to uncover undisclosed partnerships and financial arrangements between agrichemical companies, their PR groups and publicly funded professors. The investigation by U.S. Right to Know uncovered some of the key documents described in this fact sheet.

Although the Guardian later added a disclosure that Dr. Fedoroff works at the lobby firm OFW Law, it did not disclose that OFW Law’s client at the time was the agrichemical industry trade group, whose member companies were a focus of the public records investigation. The former AAAS presidents argued in their op-ed that the investigation to uncover undisclosed industry-academic conflicts of interest was “taking a page out of the Climategate playbook” and involved “science denialism,” the same claims made by industry PR groups described in this fact sheet.

Using the AAAS to advance agrichemical industry policy objectives

During her tenure as president of the American Association for the Advancement of Science (AAAS) from 2011-2012 and as Chair of the Board of Directors from 2012-2013, Dr. Fedoroff worked with agrichemical industry allies to advance key policy objectives: keeping genetically engineered foods unlabeled and defeating a proposal by the U.S. Environmental Protection Agency that would have required additional data on the health and environmental impacts of genetically engineered crops that are classified as pesticides.

AAAS helped persuade voters to oppose GMO labeling

In 2012, the AAAS Board of Directors under Dr. Fedoroff’s chairmanship took the unusual step of taking a position on a contentious political issue just two weeks before voters in California went to the polls to decide on Proposition 37, a ballot initiative to label GMOs. A review of the many political statements made by AAAS found no other examples of the organization attempting to influence voters ahead of a state election. (The AAAS and Dr. Fedoroff did not respond to requests for comment. Also disclosure: the USRTK co-directors worked on the pro-labeling campaign.)

The AAAS board’s statement opposing GMO labeling was controversial. It contained inaccuracies, according to longtime AAAS members, several of whom denounced the anti-labeling statement as a “paternalistic” attack on consumer rights that misled the public by omitting important scientific and regulatory context. An AAAS spokeswoman at the time, Ginger Pinholster, called the criticisms “unfair and without merit.” She told a reporter she was in the room when the board passed the statement: “We are not an advocacy group. We make our statements based on scientific evidence,” Pinholster said. “I can tell you that our statement is not the work of nor was it influenced by any outside organization.”

Some observers noted the similarities in language used by the AAAS and the industry-funded campaign to defeat Proposition 37. “Is a major science group stumping for Monsanto?” Michele Simon asked in Grist. Simon described the board’s statement as “non-scientific but very quote-worthy,” and noted that the accompanying AAAS press release contained “talking points” that matched No on 37 campaign literature.

“appearing to be less than transparent is a really bad idea for the scientific community”

In a 2013 letter to Science magazine, another group of 11 scientists raised concerns that the AAAS board’s statement on GMO foods “could backfire.” They wrote, “we are concerned that AAA’s position represents a poorly informed approach to communicating science …  appearing to be less than transparent is a really bad idea for the scientific community.” 

Dr. Fedoroff was an early supporter of the industry-backed No on 37 campaign, which listed her on its website in June 2012 as one of four scientists representing the “scientific and academic community” who opposed GMO labeling. The campaign later asked Dr. Fedoroff to help recruit more academics to their cause, which she did according to an October 1, 2012 email to Meghan Callahan of BCF Public Affairs, “I’ve forwarded your [request for academic supporters] to an international group of biotechnology supporting academics. I suspect you’ll be hearing from many corners of the world,” Dr. Fedoroff wrote.

Helped kill data requirements for pesticide-producing plants

In 2011 while serving as AAAS president, Dr. Fedoroff worked with agrichemical industry allies and an industry lobbyist to stop the U.S. Environmental Protection Agency from requiring companies to provide additional health and safety data for genetically engineered foods that are classified as pesticides, according to emails described below.

The EPA proposal stemmed from a 2009 EPA Scientific Advisory Panel discussion about ways to improve the agency’s ability to make regulatory decisions about plants that are genetically engineered to produce or contain pesticides, which EPA refers to as “plant-incorporated protectants” (PIPs). Panel members were asked to evaluate current and proposed EPA data requirements for PIPs in the following areas: 

  • data to assess potential similarities between PIPs and allergens, toxins, anti-nutrients and other hazardous proteins; 
  • testing for synergistic effects on health and non-target organisms, when two or more GMO traits are combined (stacked trait GMOs);
  • potential impacts on microbial populations in soil ecosystems; and 
  • data to better address the impacts of gene flow. 

According to notes from an October 2009 EPA meeting, the proposed rules would “mostly codify existing data requirements that are currently applied on a case-by-case basis,” and would encompass five categories of data and information: product characterization, human health, non-target effects, environmental fate and resistance management. EPA announced the proposed rules in the Federal Register in March 2011.

Emails obtained by U.S. Right to Know via public records requests show how industry allies mobilized to defeat the proposal.

The emails show conversations between Bruce Chassy, a University of Illinois professor at the time, Eric Sachs of Monsanto and other industry reps discussing activities and meetings that involved Dr. Fedoroff. Chassy described himself in the emails (page 66) as the liaison between industry and academics in the effort to oppose the EPA data requirements. Interspersed in his emails to Sachs were queries about whether Monsanto had sent a check to the University of Illinois Foundation in support of Chassy’s “biotechnology outreach and education activities.” (For more details about the undisclosed funds Chassy received from Monsanto for years as he promoted biotechnology, see reporting by Monica Eng in WBEZ and emails posted by the New York Times.)

On July 5, Dr. Chassy emailed Eric Sachs of Monsanto to report that Dr. Fedoroff had sent a letter to EPA over her signature co-signed by 60 members of the National Academy of Sciences. “Nina really picked up the ball and moved it down the field,” Chassy wrote. He described the EPA proposal as a “train wreck.”

The emails show that on August 19, industry trade group representatives were surprised and pleased (page 19) to see a New York Times op-ed from Dr. Fedoroff arguing against regulations for genetic engineering; “who got Nina’s op ed placed?” Adrienne Massey of BIO asked Dr. Chassy and two other industry allies, Henry Miller and Val Giddings. Chassy responded: 

Massey forwarded Dr. Chassy the letter BIO sent to the EPA “hoping to build on the academics’ letter and short-circuit any dismissive response of EPA to that letter.” Their efforts did not succeed as they hoped. On August 24, Dr. Chassy wrote to Eric Sachs (page 14) that Dr. Fedoroff “got a response from EPA that is an insult.” He described plans to ratchet up the pressure.

 

In September, Chassy organized a conference call with Fedoroff, Monsanto’s Eric Sachs, Adrienne Massey of BIO and their lobbyist Stanley Abramson, among others. According to Chassy’s notes from the call, “Finding a way to ensure that the EPA proposal never sees the light of day would be the best possible outcome we could hope for. Next best would be to make sure it is DOA, but if needs be we must be willing to continue the fight.” 

He also shared the problem that, “The EPA does not believe that the academic community can mount a sustained opposition to their proposed rule making; they believe that only a small handful are behind the petition and that most of the signatories are not committed to the issue.” The group decided they needed to “build a core of leading scientists who are in fact willing to speak out and devote time to this issue.” 

By October, the group was more hopeful. Chassy emailed Sachs to report on a “surprisingly productive” meeting he and Dr. Fedoroff attended with Steve Bradbury of EPA. The meeting had been set up by Massey and the lobbyist Abramson. The EPA proposal to require data for GMO PIPs never did see the light of day, according to Michael Hansen, PhD, senior scientist at Consumers Union, who participated in the public meetings with the agency.

Full email chains, via the UCSF Industry Documents Library: 

Related reporting  

I Was Barred from a Nobel Laureate Press Conference by a PR Consultant with Monsanto Ties,” by Tim Schwab, Food & Water Watch (2016) 

The Puppetmasters of Academia,” by Jonathan Latham, PhD, Independent Science News (2015)

20 years later: the biotech brigade marches on,” Pesticide Action Network (2012) 

Engineering food for whom?” by Marcia Ishii-Eitemann, PhD, senior scientist at Pesticide Action Network North America (2011) 

Sorry, NY Times: GMOs still won’t save the world,” by Anna Lappe, Grist (2011) 

In which I go toe to toe with H. Clinton’s science czar over GMOs,” by Tom Philpott, Grist (2009) 

Genetically Modified Diplomat: U.S. Foreign Policy GMO All the Way,” by Tom Philpott, Grist (2008)

Nina Fedoroff: Mobilizing the authority of American science to back Monsanto

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  • As a president and board chair of AAAS from 2011-2013, Dr. Fedoroff advanced agrichemical industry policy objectives. She now works for a lobbying firm.
  • Documents obtained by U.S. Right to Know show how public relations and lobbying efforts are coordinated behind the scenes among the agrichemical industry, front groups and academics who appear independent.

Nina Fedoroff, PhD, is one of the most influential scientists advocating for the proliferation and deregulation of genetically engineered foods. She is a former president of the American Association for the Advancement of Science (2011-2012) and former chair of the AAAS Board of Directors (2012-2013). She is a senior science advisor since 2015 at OFW Law, a lobbying firm whose clients have included Syngenta and the Council for Biotechnology Information, a trade group representing Bayer (which owns Monsanto), BASF, Corteva (a division of DowDuPont) and Syngenta.

From 2007-2010, Dr. Fedoroff served as science and technology advisor to the Secretary of State and the Administrator of USAID under the George W. Bush and Obama administrations. Prior to that, she was a board member of the Sigma-Aldrich Corporation, a multinational chemical and biotech firm; and an advisory board member of Evogene, a biotechnology company that partnered with DuPont, Syngenta, Bayer and Monsanto.

A 2017 event to promote the American Council on Science and Health’s “junk science” book featured Dr. Fedoroff and two scientists affiliated with groups that deny climate science.

As Secretary of State Hillary Clinton’s “science czar,” Dr. Fedoroff served as diplomat for the “GMO all the way” thrust of U.S. foreign policy, Tom Philpott reported in Grist in 2008 and 2009. Pesticide Action Network of North America has described Dr. Fedoroff as “literally the U.S. ambassador” for genetic engineering. According to Greenpeace, Dr. Fedoroff has been “a fervent advocate for the global proliferation of GM (genetically modified) foods throughout her career.”

During her tenure as president and chairman of AAAS, the world’s largest multidisciplinary scientific society, Dr. Fedoroff leveraged those roles to provide political aid to the agrichemical industry: for example, the AAAS Board of Directors under her chairmanship issued a politically timed statement to oppose GMO labeling in 2012. While president of the scientific organization in 2011, Dr. Fedoroff helped defeat a U.S. EPA proposal that would have required additional health and safety data for GMO crops, according to emails described below. See, Nina Fedoroff, AAAS and the agrichemical industry lobby. Dr. Fedoroff and AAAS have not responded to requests for response.

Affiliations with deceptive industry front groups and PR efforts

Dr. Fedoroff has promoted and helped to legitimize groups that claim to be independent voices for science but work behind the scenes with the agrichemical industry in ways that mislead the public − including two groups that helped Monsanto try to discredit the scientists who served on the World Health Organization’s International Agency for Research on Cancer (IARC) expert panel that classified glyphosate as a probable human carcinogen in 2015.

American Council on Science and Health (ACSH) is funded by chemical, pharmaceutical and tobacco companies, according to leaked internal documents that document how the group pitches its services to corporations for product-defense campaigns. Emails released via court proceedings show that Monsanto agreed to fund ACSH in 2015, and asked the group to write about the IARC cancer report on glyphosate; ACSH later claimed the cancer report was a “scientific fraud.”     

Dr. Fedoroff helped promote this group as a legitimate science source in a 2017 National Press Club event to launch the ACSH’s “Little Black Book of Junk Science.” Appearing alongside Dr. Fedoroff at the press event were two scientists affiliated with groups that deny climate science and lobby for tobacco products:

Genetic Literacy Project: Dr. Fedoroff is listed as a board member on the website of the Genetic Literacy Project, a group that claims to be independent but partners with Monsanto on PR and lobbying projects, according to documents obtained by U.S. Right to Know. Documents released in court filings show that Monsanto listed this group among the “industry partners” it planned to engage in a strategy to “orchestrate outcry” against IARC’s glyphosate assessment in order to “protect the reputation and FTO of Roundup.” Genetic Literacy Project has since posted more than 200 articles critical of the cancer research agency, including numerous personal attacks on the scientists involved in the glyphosate report, accusing them of conspiracy, fraud, lying, corruption, secrecy, and being motivated by “profit and vanity.”

In an award-winning series in Le Monde about Monsanto’s “effort to destroy the UN cancer agency by any means possible,” journalists Stéphane Foucart and Stéphane Horel described Genetic Literacy Project and ACSH as “well-known propaganda websites” and said GLP is “fed by PR people linked to the pesticides and biotechnology industries.” GLP was launched in 2011 by Jon Entine, who owns a public relations firm that had Monsanto as a client at that time.

Attacks on cancer researchers on the Genetic Literacy Project website that lists Dr. Fedoroff as a “board member”:

Academics Review: Dr. Fedoroff promoted Academics Review as a trustworthy science source in a 2012 article in Trends in Genetics and a 2016 interview with the Washington Examiner about poor science journalism. Documents obtained by U.S. Right to Know show that Academics Review was set up as a front group with the help of Monsanto to discredit critics of genetic engineering and pesticides, while keeping corporate fingerprints hidden. The group, which claimed to be independent but was funded by agrichemical companies, attacked the organic industry as a “marketing scam.”

Biotech Literacy Boot Camp: Dr. Fedoroff was listed as a core faculty member of a Biotech Literacy Project “boot camp” held at UC Davis in 2015. The event was organized by two PR groups, Genetic Literacy Project and Academics Review, and secretly funded by agrichemical companies to “train scientists and journalists to frame the debate over GMOs and the toxicity of glyphosate,” reported Paul Thacker in The Progressive. Speakers included a familiar list of industry PR allies including Jay Byrne, Jon Entine, Bruce Chassy, David Tribe, Hank Campbell of ACSH and a keynote by the “Sci Babe.”

AgBioWorld: In her 2012 Trends and Genetics article, Dr. Fedoroff promoted the website AgBioWorld as “another invaluable resource” to learn about science. In a 2002 article in the Guardian, George Monbiot described how Monsanto’s PR team used the AgBioWorld website and fake social media accounts to discredit scientists and environmentalists who raised concerns about GM crops. Monbiot reported: 

“At the end of last year, Jay Byrne, formerly [Monsanto’s] director of internet outreach, explained to a number of other firms the tactics he had used at Monsanto. He showed how, before he got to work, the top GM sites listed by an internet search engine were all critical of the technology. Following his intervention, the top sites were all supportive ones (four of them established by Monsanto’s PR firm Bivings). He told them to ‘think of the internet as a weapon on the table. Either you pick it up or your competitor does, but somebody is going to get killed.’

While he was working for Monsanto, Byrne told the internet newsletter Wow that he ‘spends his time and effort participating’ in web discussions about biotech. He singled out the site AgBioWorld, where he ‘ensures his company gets proper play.’ AgBioWorld is the site on which [fake online personality Mary] Smetacek launched her campaign.”

Attack on Greenpeace: Dr. Fedoroff spoke at a 2016 press event for a group calling itself “Support Precision Agriculture,” which presented a letter signed by over 100 Nobel laureates criticizing Greenpeace for their opposition to GMOs. Agrichemical industry allies helped out with the campaign, including Monsanto’s former Communications Director Jay Byrne; former biotech trade group VP Val Giddings; and Matt Winkler, who funds the PR group Genetic Literacy Project and is listed as a board member along with Dr. Fedoroff on the group’s website. The .com version of the supposedly independent “Support Precision Agriculture” website redirected to the Genetic Literacy Project for years (it was delinked after we called attention to it in 2019). In emails from 2011, Byrne identified Greenpeace on a “targets” list he was developing for Monsanto with names of industry critics they could confront from behind the cover of an industry-funded academic group that appeared independent.

Friend of GMO Answers: Dr. Fedoroff is an independent expert for GMO Answers, a PR campaign developed by Ketchum public relations, which has a history of using deceptive tactics to influence the public. Although Ketchum claimed the GMO Answers campaign would “redefine transparency,” the group scripted answers for an “independent” expert and was listed among the “industry partners” in Monsanto’s PR plan to protect Roundup from cancer concerns. A “resources” section (page 4) pointed to GMO Answers and Monsanto links that communicate the company message that “Glyphosate is not carcinogenic.” In 2016, Dr. Fedoroff spoke on a panel sponsored by GMO Answers, Scientific American and the Cornell Alliance for Science about media coverage of science featuring industry-friendly journalists Keith Kloor and Tamar Haspel. See “Monsanto’s Media Machine Comes to Washington,” by Paul Thacker.

Opposed investigation to uncover industry-academic ties

In 2015, Dr. Fedoroff and two other former AAAS presidents, Peter Raven and Phillip Sharp, promoted their AAAS leadership roles, but failed to disclose any of their industry ties, in a Guardian op-ed opposing a public records investigation that sought to uncover undisclosed partnerships and financial arrangements between agrichemical companies, their PR groups and publicly funded professors. The investigation by U.S. Right to Know uncovered some of the key documents described in this fact sheet.

Although the Guardian later added a disclosure that Dr. Fedoroff works at the lobby firm OFW Law, it did not disclose that OFW Law’s client at the time was the agrichemical industry trade group, whose member companies were a focus of the public records investigation. The former AAAS presidents argued in their op-ed that the investigation to uncover undisclosed industry-academic conflicts of interest was “taking a page out of the Climategate playbook” and involved “science denialism,” the same claims made by industry PR groups described in this fact sheet.

Using the AAAS to advance agrichemical industry policy objectives

During her tenure as president of the American Association for the Advancement of Science (AAAS) from 2011-2012 and as Chair of the Board of Directors from 2012-2013, Dr. Fedoroff worked with agrichemical industry allies to advance key policy objectives: keeping genetically engineered foods unlabeled and defeating a proposal by the U.S. Environmental Protection Agency that would have required additional data on the health and environmental impacts of genetically engineered crops that are classified as pesticides.

AAAS helped persuade voters to oppose GMO labeling

In 2012, the AAAS Board of Directors under Dr. Fedoroff’s chairmanship took the unusual step of taking a position on a contentious political issue just two weeks before voters in California went to the polls to decide on Proposition 37, a ballot initiative to label GMOs. A review of the many political statements made by AAAS found no other examples of the organization attempting to influence voters ahead of a state election. (The AAAS and Dr. Fedoroff did not respond to requests for comment. Also disclosure: the USRTK co-directors worked on the pro-labeling campaign.)

The AAAS board’s statement opposing GMO labeling was controversial. It contained inaccuracies, according to longtime AAAS members, several of whom denounced the anti-labeling statement as a “paternalistic” attack on consumer rights that misled the public by omitting important scientific and regulatory context. An AAAS spokeswoman at the time, Ginger Pinholster, called the criticisms “unfair and without merit.” She told a reporter she was in the room when the board passed the statement: “We are not an advocacy group. We make our statements based on scientific evidence,” Pinholster said. “I can tell you that our statement is not the work of nor was it influenced by any outside organization.”

Some observers noted the similarities in language used by the AAAS and the industry-funded campaign to defeat Proposition 37. “Is a major science group stumping for Monsanto?” Michele Simon asked in Grist. Simon described the board’s statement as “non-scientific but very quote-worthy,” and noted that the accompanying AAAS press release contained “talking points” that matched No on 37 campaign literature.

“appearing to be less than transparent is a really bad idea for the scientific community”

In a 2013 letter to Science magazine, another group of 11 scientists raised concerns that the AAAS board’s statement on GMO foods “could backfire.” They wrote, “we are concerned that AAA’s position represents a poorly informed approach to communicating science …  appearing to be less than transparent is a really bad idea for the scientific community.”

Dr. Fedoroff was an early supporter of the industry-backed No on 37 campaign, which listed her on its website in June 2012 as one of four scientists representing the “scientific and academic community” who opposed GMO labeling. The campaign later asked Dr. Fedoroff to help recruit more academics to their cause, which she did according to an October 1, 2012 email to Meghan Callahan of BCF Public Affairs, “I’ve forwarded your [request for academic supporters] to an international group of biotechnology supporting academics. I suspect you’ll be hearing from many corners of the world,” Dr. Fedoroff wrote.

Helped kill data requirements for pesticide-producing plants

In 2011 while serving as AAAS president, Dr. Fedoroff worked with agrichemical industry allies and an industry lobbyist to stop the U.S. Environmental Protection Agency from requiring companies to provide additional health and safety data for genetically engineered foods that are classified as pesticides, according to emails described below.

The EPA proposal stemmed from a 2009 EPA Scientific Advisory Panel discussion about ways to improve the agency’s ability to make regulatory decisions about plants that are genetically engineered to produce or contain pesticides, which EPA refers to as “plant-incorporated protectants” (PIPs). Panel members were asked to evaluate current and proposed EPA data requirements for PIPs in the following areas:

  • data to assess potential similarities between PIPs and allergens, toxins, anti-nutrients and other hazardous proteins;
  • testing for synergistic effects on health and non-target organisms, when two or more GMO traits are combined (stacked trait GMOs);
  • potential impacts on microbial populations in soil ecosystems; and
  • data to better address the impacts of gene flow.

According to notes from an October 2009 EPA meeting, the proposed rules would “mostly codify existing data requirements that are currently applied on a case-by-case basis,” and would encompass five categories of data and information: product characterization, human health, non-target effects, environmental fate and resistance management. EPA announced the proposed rules in the Federal Register in March 2011.

Emails obtained by U.S. Right to Know via public records requests show how industry allies mobilized to defeat the proposal.

The emails show conversations between Bruce Chassy, a University of Illinois professor at the time, Eric Sachs of Monsanto and other industry reps discussing activities and meetings that involved Dr. Fedoroff. Chassy described himself in the emails (page 66) as the liaison between industry and academics in the effort to oppose the EPA data requirements. Interspersed in his emails to Sachs were queries about whether Monsanto had sent a check to the University of Illinois Foundation in support of Chassy’s “biotechnology outreach and education activities.” (For more details about the undisclosed funds Chassy received from Monsanto for years as he promoted biotechnology, see reporting by Monica Eng in WBEZ and emails posted by the New York Times.)

On July 5, Dr. Chassy emailed Eric Sachs of Monsanto to report that Dr. Fedoroff had sent a letter to EPA over her signature co-signed by 60 members of the National Academy of Sciences. “Nina really picked up the ball and moved it down the field,” Chassy wrote. He described the EPA proposal as a “train wreck.”

The emails show that on August 19, industry trade group representatives were surprised and pleased (page 19) to see a New York Times op-ed from Dr. Fedoroff arguing against regulations for genetic engineering; “who got Nina’s op ed placed?” Adrienne Massey of BIO asked Dr. Chassy and two other industry allies, Henry Miller and Val Giddings. Chassy responded:

Massey forwarded Dr. Chassy the letter BIO sent to the EPA “hoping to build on the academics’ letter and short-circuit any dismissive response of EPA to that letter.” Their efforts did not succeed as they hoped. On August 24, Dr. Chassy wrote to Eric Sachs (page 14) that Dr. Fedoroff “got a response from EPA that is an insult.” He described plans to ratchet up the pressure.

 

In September, Chassy organized a conference call with Fedoroff, Monsanto’s Eric Sachs, Adrienne Massey of BIO and their lobbyist Stanley Abramson, among others. According to Chassy’s notes from the call, “Finding a way to ensure that the EPA proposal never sees the light of day would be the best possible outcome we could hope for. Next best would be to make sure it is DOA, but if needs be we must be willing to continue the fight.”

He also shared the problem that, “The EPA does not believe that the academic community can mount a sustained opposition to their proposed rule making; they believe that only a small handful are behind the petition and that most of the signatories are not committed to the issue.” The group decided they needed to “build a core of leading scientists who are in fact willing to speak out and devote time to this issue.”

By October, the group was more hopeful. Chassy emailed Sachs to report on a “surprisingly productive” meeting he and Dr. Fedoroff attended with Steve Bradbury of EPA. The meeting had been set up by Massey and the lobbyist Abramson. The EPA proposal to require data for GMO PIPs never did see the light of day, according to Michael Hansen, PhD, senior scientist at Consumers Union, who participated in the public meetings with the agency.

Full email chains, via the UCSF Industry Documents Library:

Related reporting 

I Was Barred from a Nobel Laureate Press Conference by a PR Consultant with Monsanto Ties,” by Tim Schwab, Food & Water Watch (2016)

The Puppetmasters of Academia,” by Jonathan Latham, PhD, Independent Science News (2015)

20 years later: the biotech brigade marches on,” Pesticide Action Network (2012)

Engineering food for whom?” by Marcia Ishii-Eitemann, PhD, senior scientist at Pesticide Action Network North America (2011)

Sorry, NY Times: GMOs still won’t save the world,” by Anna Lappe, Grist (2011)

In which I go toe to toe with H. Clinton’s science czar over GMOs,” by Tom Philpott, Grist (2009)

Genetically Modified Diplomat: U.S. Foreign Policy GMO All the Way,” by Tom Philpott, Grist (2008)

Tracking the Agrichemical Industry Propaganda Network

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Propaganda: information, especially of a biased or misleading nature, used to promote or publicize a particular political cause or point of view

Just four corporations now control more than 60% of the global supply of seeds and pesticides. Public oversight of their activities is crucial for a safe and healthy food supply. Yet all of these companies – Monsanto/Bayer, DowDuPont, Syngenta/ChemChina and BASF – have documented histories of hiding the health risks and environmental harms of their products. Since their records do not inspire trust, these companies rely on third-party allies to promote and defend their products. 

The public has a right to know about the industry ties of industry PR and lobbying aides. U.S. Right to Know has uncovered many documents that shine light on how the hidden corporate connections of front groups, academics, journalists and regulators who oppose transparency and public health protections for genetically engineered foods and pesticides. The following fact sheets provide more information: 

Academics Review: the making of a Monsanto front group

AgBioChatter: where corporations and academics plotted strategy on GMOs and pesticides

Alison Van Eenennaam: key outside spokesperson and lobbyist for the agrichemical and GMO industries

American Council on Science and Health is a corporate front group

Bayer’s Shady PR Firms: FleishmanHillard and Ketchum PR

Biofortified aids chemical industry PR & lobbying efforts

Center for Food Integrity food and agrichemical industry PR partners

Cornell Alliance for Science is a public relations campaign at Cornell to promote GMOs

Drew Kershen: agrichemical industry front group ringleader

Food Evolution GMO Documentary is a misleading propaganda film, say many academics

Geoffrey Kabat: ties to tobacco and chemical industry groups

Glyphosate Spin Check: tracking claims about the most-widely used herbicide

GMO Answers is a crisis management PR tool for GMOs & pesticides

Hank Campbell’s maze of Monsanto-loving science blogs

Henry I. Miller dropped by Forbes for Monsanto ghostwriting scandal

Independent Women’s Forum: Koch-funded group defends pesticide, oil, tobacco industries

International Food Information Council (IFIC): how Big Food spins bad news

International Life Sciences Institute (ILSI) is a food industry lobby group, documents show

Jay Byrne: meet the man behind the Monsanto PR machine

Jon Entine, Genetic Literacy Project: key messengers for Monsanto, Bayer and the chemical industry

Keith Kloor: how a science journalist worked with industry allies behind the scenes

Kevin Folta’s misleading and deceptive claims

Mark Lynas of Cornell Alliance for Science promotes the agrichemical industry’s commercial agenda

Monsanto named these “industry partners” in its PR plan to confront glyphosate cancer ruling (2015)

Nina Federoff mobilized the authority of American science to back Monsanto

Pamela Ronald’s ties to chemical industry front groups

SciBabe says eat your pesticides, but who is paying her?

Science Media Centre promotes corporate views of science

Sense About Science/STATS spin science for industry

Tamar Haspel misleads readers of the Washington Post in her food columns

Val Giddings: former BIO VP is a top operative for the agrichemical industry

More fact sheets about key front groups, trade groups and PR writers:

BIO: biotech industry trade group

Calorie Control Council

Center for Consumer Freedom

Crop Life International

International Life Sciences Institute

International Dairy Association

Julie Kelly

Kavin Senapathy/MAMMyths

Ketchum PR

International Farmers and Ranchers Alliance

Science fact sheets:

Aspartame: Decades of Science Point to Serious Health Risks

Aspartame Tied to Weight Gain, Increased Appetite, Obesity

Glyphosate: Health Concerns About Most Widely Used Pesticide

You can learn more about the findings of the U.S. Right to Know investigation here and see here for a list of global news coverage about our top findings. If you like our work, please consider donating here to keep the USRTK investigation cooking.

Top Findings of the U.S. Right To Know Investigations

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U.S. Right to Know, a nonprofit investigative group, has obtained hundreds of thousands of pages of documents revealing – for the first time – how food and pesticide corporations are working behind the scenes to undermine our nation’s scientific, academic, political and regulatory institutions. Many of these documents are now posted in the free, searchable industry document archives hosted by the University of California, San Francisco. See the USRTK Agrichemical Industry Collection and Food Industry Collection.

U.S. Right to Know provides documents free of charge to journalists, researchers, policymakers and the public around the world. Our work has contributed to two front-page New York Times investigations; six articles in the BMJ, one of the world’s leading medical journals, and many stories in other top news outlets and journals. Our own reporting has been published in the Guardian and Time magazine, among other outlets. See highlights below. For a fuller list of our investigative work and reporting about it, see our investigations page.

New York Times: Food Industry Enlisted Academics in G.M.O. Lobbying War, Emails Show, by Eric Lipton

New York Times: New C.D.C. Chief Saw Coca-Cola as Ally in Obesity Fight, by Sheila Kaplan

New York Times: Scientists, Give Up Your Emails, by Paul Thacker

New York Times: Traces of Controversial Herbicide Are Found in Ben & Jerry’s Ice Cream, by Stephanie Strom

Washington Post: Coca-Cola emails reveal how soda industry tries to influence health officials, by Paige Winfield Cunningham

BMJ: Coca-Cola and obesity: study shows efforts to influence US Centers for Disease Control, by Gareth Iocabucci

BMJ: International Life Sciences Institute is Advocate for Food and Drink Industry, Say Researchers

BMJ: Coca-Cola Contracts Could Allow it to “Quash” Unfavourable Research, by Elisabeth Mahase

BMJ: Coca-Cola’s Influence on Medical and Science Journalists, by Paul Thacker

BMJ: Conflicts of interest compromise US public health agency’s mission, say scientists, by Jeanne Lenzer

BMJ: US public health agency sued over failure to release emails from Coca-Cola, by Martha Rosenberg

TIME: FDA to Start Testing for Chemicals in Food, by Carey Gillam

TIME: I Won a Historic Lawsuit, But May Not Live to See the Money, by Carey Gillam

Island Press: Whitewash: The Story of a Weed Killer, Cancer and the Corruption of Science, by Carey Gillam

Boston Globe: Harvard Professor Failed to Disclose Monsanto Connection in Paper Touting GMOs, by Laura Krantz

The Guardian: Science Institute That Advised EU and UN ‘Actually Industry Lobby Group’, by Arthur Neslen

The Guardian: How Monsanto Manipulates Journalists and Academics, by Carey Gillam

The Guardian: The EPA Is Meant to Protect Us.  The Monsanto Trials Suggest It Isn’t Doing That, by Nathan Donley and Carey Gillam

The Guardian: Who Is Paying for Monsanto’s Crimes?  We Are.  By Carey Gillam.

The Guardian: Weedkiller ‘Raises Risk of Non-Hodgkin Lymphoma by 41%’, by Carey Gillam

The Guardian: ‘The World Is Against Them’: New Era of Cancer Lawsuits Threaten Monsanto, by Carey Gillam

The Guardian: One Man’s Suffering Exposed Monsanto’s Secrets to the World, by Carey Gillam

The Guardian: Landmark Lawsuit Claims Monsanto Hid Cancer Danger of Weedkiller for Decades, by Carey Gillam

The Guardian: Weedkiller Products More Toxic Than Their Active Ingredients, by Carey Gillam

The Guardian: Weedkiller Found in Granola and Crackers, Internal FDA Emails Show, by Carey Gillam

The Guardian: Monsanto says its pesticides are safe. Now, a court wants to see the proof, by Carey Gillam

The GuardianUN/WHO Panel in Conflict of Interest Row over Glyphosate Cancer Risk, by Arthur Neslen

The Guardian: Before you read another health study, check who’s funding the research, by Alison Moodie

Associated Press: Reports: Limit food industry sway on public health matters, by Candice Choi

Journal of Epidemiology and Community Health: Science organisations and Coca-Cola’s ‘war’ with the public health community: insights from an internal industry document, by Pepita Barlow, Paulo Serôdio, Gary Ruskin, Martin McKee and David Stuckler

Milbank Quarterly: Public Meets Private: Conversations Between Coca-Cola and the CDC.  By Nason Maani Hessari, Gary Ruskin, Martin McKee and David Stuckler

Journal of Public Health Policy: “Always read the small print”: a case study of commercial research funding, disclosure and agreements with Coca-Cola, by Sarah Steele, Gary Ruskin, Martin McKee and David Stuckler

Journal of Public Health Policy: Roundup litigation discovery documents: implications for public health and journal ethics, by Sheldon Krimsky and Carey Gillam

Journal of Public Health Policy: Case-study of emails exchanged between Coca-Cola and the principal investigators of the ISCOLE, by David Stuckler, Gary Ruskin and Martin McKee

Globalization and Health: Are Industry-Funded Charities Promoting “Advocacy-Led Studies” or “Evidence-Based Science”? A Case Study of the International Life Sciences Institute.  By Sarah Steele, Gary Ruskin, Lejla Sarjevic, Martin McKee and David Stuckler

Nature Biotechnology: Standing Up for Transparency, by Stacy Malkan

The Intercept: Trump’s New CDC Chief Championed Partnership with Coca-Cola to Solve Childhood Obesity, by Lee Fang

Los Angeles Times: In Science, Follow the Money If You Can, by Paul Thacker and Curt Furberg

San Francisco Chronicle: Major Brands Reverse Course on Genetically Modified Food Labels, by Tara Duggan

Undark: Corporate-Spun Science Should Not Be Guiding Policy, by Carey Gillam

WBEZ: Why Didn’t an Illinois Professor Have to Disclose GMO Funding?, by Monica Eng

San Diego Union TribuneUCSD hires Coke-funded health researcher, by Morgan Cook

Bloomberg: Emails Show How Food Industry Uses ‘Science’ to Push Soda, by Deena Shanker

Bloomberg: How Monsanto Mobilized Academics to Pen Articles Supporting GMOs, by Jack Kaskey

CBC: University of Saskatchewan Prof Under Fire for Monsanto Ties, by Jason Warick

CBC: U of S Defends Prof’s Monsanto Ties, But Some Faculty Disagree, by Jason Warick

ABC Australia: Leaked Email Exchange Reveals Food Industry Tactics, byLexi Metherell

ABC Australia: The Monsanto Papers broadcast

Le Monde: Comment Coca-Cola a bafoué ses promesses de transparence dans les contrats de recherche, by Stéphane Horel

Le Monde: Monsanto Papers series, by Stéphane Foucart and Stéphane Horel

The Nation: Did Monsanto Ignore Evidence Linking its Weed Killer to Cancer? by Rene Ebersole

Mother Jones: These Emails Show Monsanto Leaning on Professors to Fight the GMO PR War, by Tom Philpott

Politico: Coca-Cola gained control over health research in return for funding, health journal says, by Jesse Chase-Lubitz

The Progressive: Flacking for GMOs: How the Biotech Industry Cultivates Positive Media — and Discourages Criticism, by Paul Thacker

Freedom of the Press Foundation: How corporations suppress disclosure of public records about themselves, by Camille Fassett

Global News: Documents Reveal Canadian Teenager Target of GMO Lobby, by Allison Vuchnich

Forbes: The Coca-Cola Network: Soda Giant Mines Connections with Officials and Scientists to Wield Influence, by Rob Waters

STAT: Study pulls back curtain on contracts between Coca-Cola and the researchers it funds, by Andrew Joseph

STAT: Disney, Fearing a Scandal, Tries to Press Journal to Withdraw Research Paper, by Sheila Kaplan

Environmental Health News: Coca cola war with public health science over obesity, by Gary Ruskin

Environmental Health News: Essay: Monsanto’s ghostwriting and strong-arming threaten sound science — and society, by Sheldon Krimsky

Salon: Two Congresswomen Want an Investigation into CDC’s Relationship with Coca-Cola, by Nicole Karlis

Critical Public Health: How food companies influence evidence and opinion – straight from the horse’s mouth, by Gary Sacks, Boyd Swinburn, Adrian Cameron and Gary Ruskin

TruthOut: Secret Documents Expose Monsanto’s War on Cancer Scientists

Huffington Post: articles by Carey Gillam

Huffington Post: articles by Stacy Malkan

Philadelphia Inquirer: Coca-Cola’s research contracts allowed for quashing negative health findings, study finds, by Mari A. Shaefer

Common Ground magazine: Are you ready for the new wave of genetically engineered foods?, by Stacy Malkan

EcoWatch: articles by U.S. Right to Know

Ralph Nader: Monsanto and its Promoters vs. Freedom of Information

Gizmodo: Coca-Cola Can Terminate Health Research It Funds, Investigation Finds, by Ed Cara

Inverse: University Records Reveal Coca-Cola’s Immense Power Over Health Research, by Peter Hess

USRTK: Tracking the agrichemical industry propaganda network

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International Life Sciences Institute (ILSI) is a Food Industry Lobby Group

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The International Life Sciences Institute (ILSI) is a corporate-funded nonprofit organization based in Washington DC, with 17 affiliated chapters around the world. ILSI describes itself as a group that conducts “science for the public good” and “improves human health and well-being and safeguards the environment.” However, investigations by academics, journalists and public interest researchers show that ILSI is a lobby group that protects the interests of the food industry, not public health.

ILSI background and funding

ILSI was founded in 1978 by Alex Malaspina, a former senior vice president at Coca-Cola who worked for Coke from 1969-2001. Coca-Cola has kept close ties with ILSI. Michael Ernest Knowles, Coca-Cola’s VP of global scientific and regulatory affairs from 2008–2013, was president of ILSI from 2009-2011. In 2015, ILSI’s president was Rhona Applebaum, who retired from her job as Coca-Cola’s chief health and science officer (and from ILSI) in 2015 after the New York Times and Associated Press reported that Coke funded the nonprofit Global Energy Balance Network to help shift blame for obesity away from sugary drinks.  

Emails obtained by U.S. Right to Know and reported in a 2016 study revealed that Coke proposed and financed the Global Energy Balance Network as a “weapon” in the “growing war between the pubic health community and private industry” over obesity and the obesity epidemic. 

ILSI is funded by its corporate members and company supporters, including leading food and chemical companies such as Coca-Cola, BASF, Bayer, DuPont, Syngenta, Mars, McDonalds, chemical industry trade groups, and many others. In its annual report, ILSI and its branches reported $17,481,251 in expenses for 2017 but did not disclose specific donor information. 

U.S. Right to Know obtained a document via a state freedom of information request showing corporate contributions to ILSI Global amounting to  $2.4 million in 2012. The largest donations were $500,000 from Monsanto and over $500,000 from the pesticide industry trade group, Crop Life International. ILSI’s draft 2013 IRS tax returns show $337,000 in donations from Coca-Cola and over $650,000 from six agrichemical companies, BASF, Bayer, Dow, Monsanto, Pioneer Hi Bred and Syngenta. 

Emails show how ILSI seeks to influence policy to promote industry views 

A June 2019 paper in Globalization and Health provides several examples of how ILSI advances the interests of the food industry, especially by promoting industry-friendly science and arguments to policymakers. The study is based on documents obtained by U.S. Right to Know via state public records laws.  

The researchers concluded: “ILSI seeks to influence individuals, positions, and policy, both nationally and internationally, and its corporate members deploy it as a tool to promote their interests globally. Our analysis of ILSI serves as a caution to those involved in global health governance to be wary of putatively independent research groups, and to practice due diligence before relying upon their funded studies and/or engaging in relationship with such groups.”   

As one example, the paper quotes an email from Alex Malaspina, the former Coca-Cola executive who founded ILSI, lamenting the failure of ILSI Mexico to follow the industry position on soda taxes. Malaspina describes “the mess ILSI Mexico is in because they sponsored in September a sweeteners conference when the subject of soft drinks taxation was discussed. ILSI is now suspending ILSI Mexico, until they correct their ways. A real mess.” 

ILSI undermined obesity fight in China

In January 2019, two papers by Harvard Professor Susan Greenhalgh revealed ILSI’s powerful influence on the Chinese government on issues related to obesity. The papers document how Coca-Cola and other corporations worked through the China branch of ILSI to influence decades of Chinese science and public policy on obesity and diet-related illnesses such as Type 2 diabetes and hypertension. Read the papers:

ILSI is so well-placed in China that it operates from inside the government’s Centre for Disease Control and Prevention in Beijing.

Professor Geenhalgh’s papers document how Coca-Cola and other Western food and beverage giants “helped shape decades of Chinese science and public policy on obesity and diet-related diseases” by operating through ILSI to cultivate key Chinese officials “in an effort to stave off the growing movement for food regulation and soda taxes that has been sweeping the west,” the New York Times reported.  

Additional academic research from U.S. Right to Know about ILSI 

The UCSF Tobacco Industry Documents Archive has over 6,800 documents pertaining to ILSI.  

ILSI sugar study “right out of the tobacco industry’s playbook”

Public health experts denounced an ILSI-funded sugar study published in a prominent medical journal in 2016 that was a “scathing attack on global health advice to eat less sugar,” reported Anahad O’Connor in The New York Times. The ILSI-funded study argued that warnings to cut sugar are based on weak evidence and cannot be trusted.  

The Times story quoted Marion Nestle, a professor at New York University who studies conflicts of interest in nutrition research, on the ILSI study: “This comes right out of the tobacco industry’s playbook: cast doubt on the science,” Nestle said. “This is a classic example of how industry funding biases opinion. It’s shameful.” 

Tobacco companies used ILSI to thwart tobacco policies 

A July 2000 report by an independent committee of the World Health Organization outlined a number of ways in which the tobacco industry attempted to undermine WHO tobacco control efforts, including using scientific groups to influence WHO’s decision-making and to manipulate scientific debate surrounding the health effects of tobacco. ILSI played a key role in these efforts, according to a case study on ILSI that accompanied the report. Findings indicate that ILSI was used by certain tobacco companies to thwart tobacco control policies. Senior office bearers in ILSI were directly involved in these actions,” according to the case study. See: 

The UCSF Tobacco Industry Documents Archive has more than 6,800 documents pertaining to ILSI

ILSI leaders played key role in defending glyphosate as chairs of JMPR panel 

In May 2016, ILSI came under scrutiny after revelations that the vice president of ILSI Europe, Professor Alan Boobis, was also chairman of a UN panel that found Monsanto’s chemical glyphosate was unlikely to pose a cancer risk through diet. The co-chair of the UN Joint Meeting on Pesticide Residues (JMPR), Professor Angelo Moretto, was a board member of ILSI’s Health and Environment Services Institute. Neither of the JMPR chairs declared their ILSI leadership roles as conflicts of interest, despite the significant financial contributions ILSI has received from Monsanto and the pesticide industry trade group. See: 

ILSI’s cozy ties at U.S. Centers for Disease Control and Prevention  

In June 2016, U.S. Right to Know reported that Dr. Barbara Bowman, director of a CDC division charged with preventing heart disease and stroke, tried to help ILSI’s founder Alex Malaspina influence World Health Organization officials to back off policies to reduce sugar consumption. Bowman suggested people and groups for Malaspina to talk to, and solicited his comments on some CDC summaries of reports, the emails show. (Bowman stepped down after our first article was published reporting on these ties.)

This January 2019 study in the Milbank Quarterly describes key emails of Malaspina cozying up to Dr. Bowman. For more reporting on this topic, see: 

ILSI influence in India 

ILSI has close ties to some Indian government officials and, as in China, the nonprofit has pushed similar messaging and policy proposals as Coca-Cola – downplaying the role of sugar and diet as a cause of obesity, and promoting increased physical activity as the solution, according to the India Resource Center. 

Members of ILSI India’s board of trustees include Coca-Cola India’s director of regulatory affairs and representatives from Nestlé and Ajinomoto, a food additive company, along with government officials who serve on scientific panels that are tasked with deciding about food safety issues.  

Longstanding concerns about ILSI 

ILSI insists it is not an industry lobby group, but concerns and complaints are longstanding about the group’s pro-industry stances and conflicts of interest among the organization’s leaders. See, for example:

Food agency denies conflict-of-interest claim. But accusations of industry ties may taint European body’s reputation, Nature (2010)

Big Food Vs. Tim Noakes: The Final Crusade, Keep Fitness Legal, by Russ Greene (1.5.17) 

Real Food on Trial, by Dr. Tim Noakes and Marika Sboros (Columbus Publishing 2019). The book describes “the unprecedented prosecution and persecution of Professor Tim Noakes, a distinguished scientist and medical doctor, in a multimillion rand case that stretched over more than four years. All for a single tweet giving his opinion on nutrition.”

Aspartame: Decades of Science Point to Serious Health Risks

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Long History of Concerns
Key Scientific Studies on Aspartame
Industry PR Efforts
Scientific References

Key Facts About Diet Soda Chemical 

What is Aspartame?

  • Aspartame is the world’s most widely used artificial sweetener. It is also marketed as NutraSweet, Equal, Sugar Twin and AminoSweet.
  • Aspartame is present in more than 6,000 products, including Diet Coke and Diet Pepsi, Kool Aid, Crystal Light, Tango and other artificially sweetened drinks; sugar-free Jell-O products; Trident, Dentyne and most other brands of sugar-free gum; sugar-free hard candies; low- or no-sugar sweet condiments such as ketchups and dressings; children’s medicines, vitamins and cough drops.
  • Aspartame is a synthetic chemical composed of the amino acids phenylalanine and aspartic acid, with a methyl ester. When consumed, the methyl ester breaks down into methanol, which may be converted into formaldehyde.

Decades of Studies Raise Concerns about Aspartame

Since aspartame was first approved in 1974, both FDA scientists and independent scientists have raised concerns about possible health effects and shortcomings in the science submitted to the FDA by the manufacturer, G.D. Searle. (Monsanto bought Searle in 1984).

In 1987, UPI published a series of investigative articles by Gregory Gordon reporting on these concerns, including early studies linking aspartame to health problems, the poor quality of industry-funded research that led to its approval, and the revolving-door relationships between FDA officials and the food industry. Gordon’s series is an invaluable resource for anyone seeking to understand the history of aspartame/NutraSweet:

Serious flaws in European Food Safety Authority safety assessment: In a July 2019 paper in the Archives of Public Health, researchers at the University of Sussex provided a detailed analysis of the EFSA’s 2013 safety assessment of aspartame and found that the panel discounted as unreliable every one of 73 studies that indicated harm, and used far more lax criteria to accept as reliable 84% of studies that found no evidence of harm. “Given the shortcomings of EFSA’s risk assessment of aspartame, and the shortcomings of all previous official toxicological risk assessments of aspartame, it would be premature to conclude that it is acceptably safe,” the study concluded. See also,

  • “‘Sales of aspartame should be suspended’: EFSA accused of bias in safety assessment,” by Katy Askew, Food Navigator (7.27.2019)

Health Effects and Key Studies on Aspartame 

While many studies, some of them industry sponsored, have reported no problems with aspartame, dozens of independent studies conducted over decades have linked aspartame to a long list of health problems, including:

Cancer

In the most comprehensive cancer research to date on aspartame, three lifespan studies conducted by the Cesare Maltoni Cancer Research Center of the Ramazzini Institute, provide consistent evidence of carcinogenicity in rodents exposed to the substance.

  • Aspartame “is a multipotential carcinogenic agent, even at a daily dose of … much less than the current acceptable daily intake,” according to a 2006 lifespan rat study in Environmental Health Perspectives.1
  • A follow-up study in 2007 found significant dose-related increases in malignant tumors in some of the rats. “The results … confirm and reinforce the first experimental demonstration of [aspartame’s] multipotential carcinogenicity at a dose level close to the acceptable daily intake for humans … when life-span exposure begins during fetal life, its carcinogenic effects are increased,” the researchers wrote in Environmental Health Perspectives.2
  • The results of a 2010 lifespan study “confirm that [aspartame] is a carcinogenic agent in multiple sites in rodents, and that this effect is induced in two species, rats (males and females) and mice (males),” the researchers reported in American Journal of Industrial Medicine.3

Harvard researchers in 2012 reported a positive association between aspartame intake and increased risk of non-Hodgkin lymphoma and multiple myeloma in men, and for leukemia in men and women. The findings “preserve the possibility of a detrimental effect … on select cancers” but “do not permit the ruling out of chance as an explanation,” the researchers wrote in the American Journal of Clinical Nutrition.4

In a 2014 commentary in American Journal of Industrial Medicine, the Maltoni Center researchers wrote that the studies submitted by G. D. Searle for market approval “do not provide adequate scientific support for [aspartame’s] safety. In contrast, recent results of life-span carcinogenicity bioassays on rats and mice published in peer-reviewed journals, and a prospective epidemiological study, provide consistent evidence of [aspartame’s] carcinogenic potential. On the basis of the evidence of the potential carcinogenic effects … a re-evaluation of the current position of international regulatory agencies must be considered an urgent matter of public health.”5

Brain Tumors

In 1996, researchers reported in the Journal of Neuropathology & Experimental Neurology on epidemiological evidence connecting the introduction of aspartame to an increase in an aggressive type of malignant brain tumors. “Compared to other environmental factors putatively linked to brain tumors, the artificial sweetener aspartame is a promising candidate to explain the recent increase in incidence and degree of malignancy of brain tumors … We conclude that there is need for reassessing the carcinogenic potential of aspartame.”6

  • Neuroscientist Dr. John Olney, lead author of the study, told 60 minutes in 1996: “there has been a striking increase in the incidence of malignant brain tumors (in the three to five years following the approval of aspartame) … there is enough basis to suspect aspartame that it needs to be reassessed. FDA needs to reassess it, and this time around, FDA should do it right.”

Early studies on aspartame in the 1970s found evidence of brain tumors in laboratory animals, but those studies were not followed up.

Cardiovascular Disease 

A 2017 meta-analysis of research on artificial sweeteners, published in the Canadian Medical Association Journal, found no clear evidence of weight loss benefits for artificial sweeteners in randomized clinical trials, and reported that cohort studies associate artificial sweeteners with “increases in weight and waist circumference, and higher incidence of obesity, hypertension, metabolic syndrome, type 2 diabetes and cardiovascular events.”7 See also:

  • “Artificial sweeteners don’t help with weight loss and may lead to gained pounds,” by Catherine Caruso, STAT (7.17.2017)
  • “Why one cardiologist has drunk his last diet soda,” by Harlan Krumholz, Wall Street Journal (9.14.2017)
  • “This cardiologist wants his family to cut back on diet soda. Should yours, too?” by David Becker, M.D., Philly Inquirer (9.12.2017)

 A 2016 paper in Physiology & Behavior reported, “there is a striking congruence between results from animal research and a number of large-scale, long-term observational studies in humans, in finding significantly increased weight gain, adiposity, incidence of obesity, cardiometabolic risk, and even total mortality among individuals with chronic, daily exposure to low-calorie sweeteners – and these results are troubling.”8

Women who consumed more than two diet drinks per day “had a higher risk of [cardiovascular disease] events … [cardiovascular disease] mortality … and overall mortality,” according to a 2014 study from the Women’s Health Initiative published in the Journal of General Internal Medicine.9

Stroke, Dementia and Alzheimer’s Disease

People drinking diet soda daily were almost three times as likely to develop stroke and dementia as those who consumed it weekly or less. This included a higher risk of ischemic stroke, where blood vessels in the brain become obstructed, and Alzheimer’s disease dementia, the most common form of dementia, reported a 2017 study in Stroke.10

In the body, the methyl ester in aspartame metabolizes into methanol and then it may be converted to formaldehyde, which has been linked to Alzheimer’s disease. A two-part study published in 2014 in the Journal of Alzheimer’s Disease linked chronic methanol exposure to memory loss and Alzheimer’s Disease symptoms in mice and monkeys.

  • “[M]ethanol-fed mice presented with partial AD-like symptoms … These findings add to a growing body of evidence that links formaldehyde to [Alzheimer’s disease] pathology.” (Part 1)11
  • “[M]ethanol feeding caused long-lasting and persistent pathological changes that were related to [Alzheimer’s disease] … these findings support a growing body of evidence that links methanol and its metabolite formaldehyde to [Alzheimer’s disease] pathology.” (Part 2)12

Seizures

“Aspartame appears to exacerbate the amount of EEG spike wave in children with absence seizures. Further studies are needed to establish if this effect occurs at lower doses and in other seizure types,” according to a 1992 study in Neurology.13

Aspartame “has seizure-promoting activity in animal models that are widely used to identify compounds affecting … seizure incidence,” according to a 1987 study in Environmental Health Perspectives.14

Very high aspartame doses “might also affect the likelihood of seizures in symptomless but susceptible people,” according to a 1985 study in The Lancet. The study describes three previously healthy adults who had grand mal seizures during periods when they were consuming high doses of aspartame.15

Neurotoxicity, Brain Damage and Mood Disorders

Aspartame has been linked to behavioral and cognitive problems including learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia, wrote the researchers of a 2017 study in Nutritional Neuroscience. “Aspartame consumption needs to be approached with caution due to the possible effects on neurobehavioral health.”16

“Oral aspartame significantly altered behavior, anti-oxidant status and morphology of the hippocampus in mice; also, it may probably trigger hippocampal adult neurogenesis,” reported a 2016 study in Neurobiology of Learning and Memory.17 

“Previously, it has been reported that consumption of aspartame could cause neurological and behavioural disturbances in sensitive individuals. Headaches, insomnia and seizures are also some of the neurological effects that have been encountered,” according to a 2008 study in the European Journal of Clinical Nutrition. “[W]e propose that excessive aspartame ingestion might be involved in the pathogenesis of certain mental disorders … and also in compromised learning and emotional functioning.”18 

“(N)eurological symptoms, including learning and memory processes, may be related to the high or toxic concentrations of the sweetener [aspartame] metabolites,” states a 2006 study in Pharmacological Research.19

Aspartame “could impair memory retention and damage hypothalamic neurons in adult mice,” according to a 2000 mice study published in Toxicology Letters.20

“(I)ndividuals with mood disorders are particularly sensitive to this artificial sweetener and its use in this population should be discouraged,” according to a 1993 study in the Journal of Biological Psychiatry.21

High doses of aspartame “can generate major neurochemical changes in rats,” reported a 1984 study in American Journal of Clinical Nutrition.22

Experiments indicated brain damage in infant mice following oral intake of aspartate, and showing that “aspartate [is] toxic to the infant mouse at relatively low levels of oral intake,” reported a 1970 study in Nature.23

Headaches and Migraines

“Aspartame, a popular dietetic sweetener, may provoke headache in some susceptible individuals. Herein, we describe three cases of young women with migraine who reported their headaches could be provoked by chewing sugarless gum containing aspartame,” according to a 1997 paper in Headache Journal.24

A crossover trial comparing aspartame and a placebo published in 1994 in Neurology, “provides evidence that, among individuals with self-reported headaches after ingestion of aspartame, a subset of this group report more headaches when tested under controlled conditions. It appears that some people are particularly susceptible to headaches caused by aspartame and may want to limit their consumption.”25

A survey of 171 patients at the Montefiore Medical Center Headache Unit found that patients with migraine “reported aspartame as a precipitant three times more often than those having other types of headache … We conclude aspartame may be an important dietary trigger of headache in some people,” 1989 study in Headache Journal.26

A crossover trial comparing aspartame and a placebo on the frequency and intensity of migraines “indicated that the ingestion of aspartame by migraineurs caused a significant increase in headache frequency for some subjects,” reported a 1988 study in Headache Journal.27

Kidney Function Decline

Consumption of more than two servings a day of artificially sweetened soda “is associated with a 2-fold increased odds for kidney function decline in women,” according to a 2011 study in the Clinical Journal of American Society of Nephrology.28

Weight Gain, Increased Appetite and Obesity Related Problems

Several studies link aspartame to weight gain, increased appetite, diabetes, metabolic derangement and obesity-related diseases. See our fact sheet: Diet Soda Chemical Tied to Weight Gain.

This science linking aspartame to weight gain and obesity-related diseases raises questions about the legality of marketing aspartame-containing products as “diet” or weight loss aids. In 2015, USRTK petitioned the Federal Trade Commission and FDA to investigate the marketing and advertising practices of “diet” products that contain a chemical linked to weight gain. See related news coverage, response from FTC, and response from FDA.

Diabetes and Metabolic Derangement

Aspartame breaks down in part into phenylalanine, which interferes with the action of an enzyme intestinal alkaline phosphatase (IAP) previously shown to prevent metabolic syndrome (a group of symptoms associated with type 2 diabetes and cardiovascular disease) according to a 2017 study in Applied Physiology, Nutrition and Metabolism. In this study, mice receiving aspartame in their drinking water gained more weight and developed other symptoms of metabolic syndrome than animals fed similar diets lacking aspartame. The study concludes, “IAP’s protective effects in regard to the metabolic syndrome may be inhibited by phenylalanine, a metabolite of aspartame, perhaps explaining the lack of expected weight loss and metabolic improvements associated with diet drinks.”29

People who regularly consume artificial sweeteners are at increased risk of “excessive weight gain, metabolic syndrome, type 2 diabetes, and cardiovascular disease,” according to a 2013 Purdue review over 40 years published in Trends in Endocrinology & Metabolism.30

In a study that followed 66,118 women over 14 years, both sugar-sweetened beverages and artificially sweetened beverages were associated with risk of Type 2 diabetes. “Strong positive trends in T2D risk were also observed across quartiles of consumption for both types of beverage … No association was observed for 100% fruit juice consumption,” reported the 2013 study published in American Journal of Clinical Nutrition.31

Intestinal Dysbiosis, Metabolic Derangement and Obesity

Artificial sweeteners can induce glucose intolerance by altering the gut microbiota, according to a 2014 study in Nature. The researchers wrote, “our results link NAS [non-caloric artificial sweetener] consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage … Our findings suggest that NAS may have directly contributed to enhancing the exact epidemic [obesity] that they themselves were intended to fight.”32

A 2016 study in Applied Physiology Nutrition and Metabolism reported, “Aspartame intake significantly influenced the association between body mass index (BMI) and glucose tolerance… consumption of aspartame is associated with greater obesity-related impairments in glucose tolerance.”33

According to a 2014 rat study in PLOS ONE, “aspartame elevated fasting glucose levels and an insulin tolerance test showed aspartame to impair insulin-stimulated glucose disposal … Fecal analysis of gut bacterial composition showed aspartame to increase total bacteria…”34

 Pregnancy Abnormalities: Pre Term Birth 

According to a 2010 cohort study of 59,334 Danish pregnant women published in the American Journal of Clinical Nutrition, “There was an association between intake of artificially sweetened carbonated and noncarbonated soft drinks and an increased risk of preterm delivery.” The study concluded, “Daily intake of artificially sweetened soft drinks may increase the risk of preterm delivery.”35

  • See also: “Downing Diet Soda Tied to Premature Birth,” by Anne Harding, Reuters (7.23.2010)

Overweight Babies

Artificially sweetened beverage consumption during pregnancy is linked to higher body mass index for babies, according to a 2016 study in JAMA Pediatrics. “To our knowledge, we provide the first human evidence that maternal consumption of artificial sweeteners during pregnancy may influence infant BMI,” the researchers wrote.36

Early Menarche

The National Heart, Lung, and Blood Institute Growth and Health Study followed 1988 girls for 10 years to examine prospective associations between consumption of caffeinated and noncaffeinated sugar- and artificially sweetened soft drinks and early menarche. “Consumption of caffeinated and artificially sweetened soft drinks was positively associated with risk of early menarche in a US cohort of African American and Caucasian girls,” concluded the study published in 2015 in Journal of American Clinical Nutrition.37

Sperm Damage

“A significant decrease in sperm function of aspartame treated animals was observed when compared with the control and MTX control,” according to a 2017 study in the International Journal of Impotence Research. “… These findings demonstrate that aspartame metabolites could be a contributing factor for development of oxidative stress in the epididymal sperm.”38

Liver Damage and Glutathione Depletion

A mouse study published in 2017 in Redox Biology reported, “Chronic administration of aspartame … caused liver injury as well as marked decreased hepatic levels of reduced glutathione, oxidized glutathione, γ-glutamylcysteine, and most metabolites of the trans-sulphuration pathway…”39

A rat study published in 2017 in Nutrition Research found that, “Subchronic intake of soft drink or aspartame substantially induced hyperglycemia and hypertriacylglycerolemia… Several cytoarchitecture alterations were detected in the liver, including degeneration, infiltration, necrosis, and fibrosis, predominantly with aspartame. These data suggest that long-term intake of soft drink or aspartame-induced hepatic damage may be mediated by the induction of hyperglycemia, lipid accumulation, and oxidative stress with the involvement of adipocytokines.”40

Caution for Vulnerable Populations

A 2016 literature review on artificial sweeteners in the Indian Journal of Pharmacology reported, “there is inconclusive evidence to support most of their uses and some recent studies even hint that these earlier established benefits … might not be true.” Susceptible populations such as pregnant and lactating women, children, diabetics, migraine, and epilepsy patients “should use these products with utmost caution.”41

Industry PR Efforts and Front Groups 

From the start, G.D. Searle (later Monsanto and the NutraSweet Company) deployed aggressive PR tactics to market aspartame as a safe product. In October 1987, Gregory Gordon reported in UPI:

“The NutraSweet Co. also has paid up to $3 million a year for a 100-person public relations effort by the Chicago offices of Burson Marsteller, a former employee of the New York PR firm said. The employee said Burson Marsteller has hired numerous scientists and physicians, often at $1,000 a day, to defend the sweetener in media interviews and other public forums. Burson Marsteller declines to discuss such matters.”

Recent reporting based on internal industry documents reveals how beverage companies such as Coca-Cola also pay third party messengers, including doctors and scientists, to promote their products and shift the blame when science ties their products to serious health problems.

See reporting by Anahad O’Connor in the New York Times, Candice Choi in the Associated Press, and findings from the USRTK investigation about sugar industry propaganda and lobbying campaigns.

News articles about soda industry PR campaigns:

Overview news stories about aspartame:

USRTK Fact Sheets

Reports on Front Groups and PR Campaigns

Scientific References

[1] Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L, Tibaldi E, Rigano A. “First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats.” Environ Health Perspect. 2006 Mar;114(3):379-85. PMID: 16507461. (article)

[2] Soffritti M, Belpoggi F, Tibaldi E, Esposti DD, Lauriola M. “Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats.” Environ Health Perspect. 2007 Sep;115(9):1293-7. PMID: 17805418. (article)

[3] Soffritti M et al. “Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.” Am J Ind Med. 2010 Dec; 53(12):1197-206. PMID: 20886530. (abstract / article)

[4] Schernhammer ES, Bertrand KA, Birmann BM, Sampson L, Willett WC, Feskanich D., “Consumption of artificial sweetener– and sugar-containing soda and risk of lymphoma and leukemia in men and women.” Am J Clin Nutr. 2012 Dec;96(6):1419-28. PMID: 23097267. (abstract / article)

[5] Soffritti M1, Padovani M, Tibaldi E, Falcioni L, Manservisi F, Belpoggi F., “The carcinogenic effects of aspartame: The urgent need for regulatory re-evaluation.” Am J Ind Med. 2014 Apr;57(4):383-97. doi: 10.1002/ajim.22296. Epub 2014 Jan 16. (abstract / article)

[6] Olney JW, Farber NB, Spitznagel E, Robins LN. “Increasing brain tumor rates: is there a link to aspartame?” J Neuropathol Exp Neurol. 1996 Nov;55(11):1115-23. PMID: 8939194. (abstract)

[7] Azad, Meghan B., et al. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. CMAJ July 17, 2017 vol. 189 no. 28 doi: 10.1503/cmaj.161390 (abstract / article)

[8] Fowler SP. Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans. Physiol Behav. 2016 Oct 1;164(Pt B):517-23. doi: 10.1016/j.physbeh.2016.04.047. Epub 2016 Apr 26. (abstract)

[9] Vyas A et al. “Diet Drink Consumption And The Risk of Cardiovascular Events: A Report from The Women’s Health Initiative.” J Gen Intern Med. 2015 Apr;30(4):462-8. doi: 10.1007/s11606-014-3098-0. Epub 2014 Dec 17. (abstract / article)

[10] Matthew P. Pase, PhD; Jayandra J. Himali, PhD; Alexa S. Beiser, PhD; Hugo J. Aparicio, MD; Claudia L. Satizabal, PhD; Ramachandran S. Vasan, MD; Sudha Seshadri, MD; Paul F. Jacques, DSc. “Sugar and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study.” Stroke. 2017 April; STROKEAHA.116.016027 (abstract / article)

[11] Yang M et al. “Alzheimer’s Disease and Methanol Toxicity (Part 1): Chronic Methanol Feeding Led to Memory Impairments and Tau Hyperphosphorylation in Mice.” J Alzheimers Dis. 2014 Apr 30. (abstract)

[12] Yang M et al. “Alzheimer’s Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol.” J Alzheimers Dis. 2014 Apr 30. (abstract)

[13] Camfield PR, Camfield CS, Dooley JM, Gordon K, Jollymore S, Weaver DF. “Aspartame exacerbates EEG spike-wave discharge in children with generalized absence epilepsy: a double-blind controlled study.” Neurology. 1992 May;42(5):1000-3. PMID: 1579221. (abstract)

[14] Maher TJ, Wurtman RJ. “Possible neurologic effects of aspartame, a widely used food additive.” Environ Health Perspect. 1987 Nov; 75:53-7. PMID: 3319565. (abstract / article)

[15] Wurtman RJ. “Aspartame: possible effect on seizure susceptibility.” Lancet. 1985 Nov 9;2(8463):1060. PMID: 2865529. (abstract)

[16] Choudhary AK, Lee YY. “Neurophysiological symptoms and aspartame: What is the connection?” Nutr Neurosci. 2017 Feb 15:1-11. doi: 10.1080/1028415X.2017.1288340. (abstract)

[17] Onaolapo AY, Onaolapo OJ, Nwoha PU. “Aspartame and the hippocampus: Revealing a bi-directional, dose/time-dependent behavioural and morphological shift in mice.” Neurobiol Learn Mem. 2017 Mar;139:76-88. doi: 10.1016/j.nlm.2016.12.021. Epub 2016 Dec 31. (abstract)

[18] Humphries P, Pretorius E, Naudé H. “Direct and indirect cellular effects of aspartame on the brain.” Eur J Clin Nutr. 2008 Apr;62(4):451-62. (abstract / article)

[19] Tsakiris S, Giannoulia-Karantana A, Simintzi I, Schulpis KH. “The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity.” Pharmacol Res. 2006 Jan;53(1):1-5. PMID: 16129618. (abstract)

[20] Park CH et al. “Glutamate and aspartate impair memory retention and damage hypothalamic neurons in adult mice.” Toxicol Lett. 2000 May 19;115(2):117-25. PMID: 10802387. (abstract)

[21] Walton RG, Hudak R, Green-Waite R. “Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population.” J. Biol Psychiatry. 1993 Jul 1-15;34(1-2):13-7. PMID: 8373935. (abstract / article)

[22] Yokogoshi H, Roberts CH, Caballero B, Wurtman RJ. “Effects of aspartame and glucose administration on brain and plasma levels of large neutral amino acids and brain 5-hydroxyindoles.” Am J Clin Nutr. 1984 Jul;40(1):1-7. PMID: 6204522. (abstract)

[23] Olney JW, Ho OL. “Brain Damage in Infant Mice Following Oral Intake of Glutamate, Aspartate or Cysteine.” Nature. 1970 Aug 8;227(5258):609-11. PMID: 5464249. (abstract)

[24] Blumenthal HJ, Vance DA. “Chewing gum headaches.” Headache. 1997 Nov-Dec; 37(10):665-6. PMID: 9439090. (abstract/article)

[25] Van den Eeden SK, Koepsell TD, Longstreth WT Jr, van Belle G, Daling JR, McKnight B. “Aspartame ingestion and headaches: a randomized crossover trial.” Neurology. 1994 Oct;44(10):1787-93. PMID: 7936222. (abstract)

[26] Lipton RB, Newman LC, Cohen JS, Solomon S. “Aspartame as a dietary trigger of headache.” Headache. 1989 Feb;29(2):90-2. PMID: 2708042. (abstract)

[27] Koehler SM, Glaros A. “The effect of aspartame on migraine headache.” Headache. 1988 Feb;28(1):10-4. PMID: 3277925. (abstract)

[28] Julie Lin and Gary C. Curhan. “Associations of Sugar and Artificially Sweetened Soda with Albuminuria and Kidney Function Decline in Women.” Clin J Am Soc Nephrol. 2011 Jan; 6(1): 160–166. (abstract / article)

[29] Gul SS, Hamilton AR, Munoz AR, Phupitakphol T, Liu W, Hyoju SK, Economopoulos KP, Morrison S, Hu D, Zhang W, Gharedaghi MH, Huo H, Hamarneh SR, Hodin RA. “Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.” Appl Physiol Nutr Metab. 2017 Jan;42(1):77-83. doi: 10.1139/apnm-2016-0346. Epub 2016 Nov 18. (abstract / article)

[30] Susan E. Swithers, “Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements.” Trends Endocrinol Metab. 2013 Sep; 24(9): 431–441. (article)

[31] Guy Fagherazzi, A Vilier, D Saes Sartorelli, M Lajous, B Balkau, F Clavel-Chapelon. “Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l’Education Nationale–European Prospective Investigation into Cancer and Nutrition cohort.” Am J Clin Nutr. 2013, Jan 30; doi: 10.3945/ ajcn.112.050997 ajcn.050997. (abstract/article)

[32] Suez J et al. “Artificial sweeteners induce glucose intolerance by altering the gut microbiota.” Nature. 2014 Oct 9;514(7521). PMID: 25231862. (abstract / article)

[33] Kuk JL, Brown RE. “Aspartame intake is associated with greater glucose intolerance in individuals with obesity.” Appl Physiol Nutr Metab. 2016 Jul;41(7):795-8. doi: 10.1139/apnm-2015-0675. Epub 2016 May 24. (abstract)

[34] Palmnäs MSA, Cowan TE, Bomhof MR, Su J, Reimer RA, Vogel HJ, et al. (2014) Low-Dose Aspartame Consumption Differentially Affects Gut Microbiota-Host Metabolic Interactions in the Diet-Induced Obese Rat. PLoS ONE 9(10): e109841. (article)

[35] Halldorsson TI, Strøm M, Petersen SB, Olsen SF. “Intake of artificially sweetened soft drinks and risk of preterm delivery: a prospective cohort study in 59,334 Danish pregnant women.” Am J Clin Nutr. 2010 Sep;92(3):626-33. PMID: 20592133. (abstract / article)

[36] Meghan B. Azad, PhD; Atul K. Sharma, MSc, MD; Russell J. de Souza, RD, ScD; et al. “Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index.” JAMA Pediatr. 2016;170(7):662-670. (abstract)

[37] Mueller NT, Jacobs DR Jr, MacLehose RF, Demerath EW, Kelly SP, Dreyfus JG, Pereira MA. “Consumption of caffeinated and artificially sweetened soft drinks is associated with risk of early menarche.” Am J Clin Nutr. 2015 Sep;102(3):648-54. doi: 10.3945/ajcn.114.100958. Epub 2015 Jul 15. (abstract)

[38] Ashok I, Poornima PS, Wankhar D, Ravindran R, Sheeladevi R. “Oxidative stress evoked damages on rat sperm and attenuated antioxidant status on consumption of aspartame.” Int J Impot Res. 2017 Apr 27. doi: 10.1038/ijir.2017.17. (abstract / article)

[39] Finamor I, Pérez S, Bressan CA, Brenner CE, Rius-Pérez S, Brittes PC, Cheiran G, Rocha MI, da Veiga M, Sastre J, Pavanato MA., “Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice.” Redox Biol. 2017 Apr;11:701-707. doi: 10.1016/j.redox.2017.01.019. Epub 2017 Feb 1. (abstract/article)

[40] Lebda MA, Tohamy HG, El-Sayed YS. “Long-term soft drink and aspartame intake induces hepatic damage via dysregulation of adipocytokines and alteration of the lipid profile and antioxidant status.” Nutr Res. 2017 Apr 19. pii: S0271-5317(17)30096-9. doi: 10.1016/j.nutres.2017.04.002. [Epub ahead of print] (abstract)

[41] Sharma A, Amarnath S, Thulasimani M, Ramaswamy S. “Artificial sweeteners as a sugar substitute: Are they really safe?” Indian J Pharmacol 2016;48:237-40 (article)

Aspartame is Tied to Weight Gain, Increased Appetite and Obesity

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Science on Weight Gain + Obesity Related Issues
Industry Science
Is “Diet” Deceptive Marketing?
Scientific References

Aspartame, the world’s most popular sugar substitute, is found in thousands of sugar-free, low-sugar and so-called “diet” drinks and foods. Yet the scientific evidence described in this fact sheet links aspartame to weight gain, increased appetite, diabetes, metabolic derangement and obesity-related diseases.

Please share this resource. See also our companion fact sheet, Aspartame: Decades of Science Point to Serious Health Risks, with information about the peer-reviewed studies linking aspartame to cancer, cardiovascular disease, Alzheimer’s disease, strokes, seizures, shortened pregnancies and headaches.

Quick Facts

  • Aspartame — also marketed as NutraSweet, Equal, Sugar Twin and AminoSweet — is the world’s most widely used artificial sweetener. The chemical is found in thousands of food and beverage products, including Diet Coke and Diet Pepsi, sugar-free gum, candy, condiments and vitamins.
  • The FDA has said aspartame is “safe for the general population under certain conditions.” Many scientists have said the FDA approval was based on suspect data and should be reconsidered.
  • Dozens of studies conducted over decades link aspartame to serious health problems.

Aspartame, Weight Gain + Obesity Related Issues 

Five reviews of the scientific literature on artificial sweeteners suggest that they do not contribute to weight loss, and instead may cause weight gain.

  • A 2017 meta analysis of research on artificial sweeteners, published in the Canadian Medical Association Journal, found no clear evidence of weight loss benefits for artificial sweeteners in randomized clinical trials, and reported that cohort studies associate artificial sweeteners with “increases in weight and waist circumference, and higher incidence of obesity, hypertension, metabolic syndrome, type 2 diabetes and cardiovascular events.”See also
    • “Artificial sweeteners don’t help with weight loss and may lead to gained pounds,” by Catherine Caruso, STAT (7.17.2017)
    • “Why one cardiologist has drunk his last diet soda,” by Harlan Krumholz, Wall Street Journal (9.14.2017)
    • “This cardiologist wants his family to cut back on diet soda. Should yours, too?” by David Becker, M.D., Philly Inquirer (9.12.2017)
  • A 2013 Trends in Endocrinology and Metabolism review article finds “accumulating evidence suggests that frequent consumers of these sugar substitutes may also be at increased risk of excessive weight gain, metabolic syndrome, type 2 diabetes, and cardiovascular disease,” and that “frequent consumption of high-intensity sweeteners may have the counterintuitive effect of inducing metabolic derangements.”2
  • A 2009 American Journal of Clinical Nutrition review article finds that the “addition of NNS [nonnutritive sweeteners] to diets poses no benefit for weight loss or reduced weight gain without energy restriction. There are long-standing and recent concerns that inclusion of NNS in the diet promotes energy intake and contributes to obesity.”3
  • A 2010 Yale Journal of Biology and Medicine review of the literature on artificial sweeteners concludes that, “research studies suggest that artificial sweeteners may contribute to weight gain.”4
  • A 2010 International Journal of Pediatric Obesity review article states, “Data from large, epidemiologic studies support the existence of an association between artificially-sweetened beverage consumption and weight gain in children.”5

Epidemiological evidence suggests that artificial sweeteners are implicated in weight gain. For example:

  • The San Antonio Heart Study “observed a classic, positive dose-response relationship between AS [artificially sweetened] beverage consumption and long-term weight gain.” Furthermore, it found that consuming more than 21 artificially sweetened beverages per week – compared to those who consumed none, “was associated with almost-doubled risk” of overweight or obesity.”6
  • A study of beverage consumption among children and adolescents aged 6-19 published in International Journal of Food Sciences and Nutrition found that “BMI is positively associated with consumption of diet carbonated beverages.”7
  • A two-year study in of 164 children published in the Journal of the American College of Nutrition found that “Increases in diet soda consumption were significantly greater for overweight and subjects who gained weight as compared to normal weight subjects. Baseline BMI Z-score and year 2 diet soda consumption predicted 83.1% of the variance in year 2 BMI Z-score.” It also found that “Diet soda consumption was the only type of beverage associated with year 2 BMI Z-score, and consumption was greater in overweight subjects and subjects who gained weight as compared to normal weight subjects at two years.”8
  • The U.S. Growing Up Today study of more than 10,000 children aged 9-14 found that, for boys, intakes of diet soda “were significantly associated with weight gains.”9
  • A 2016 study in the International Journal of Obesity reported finding seven tentatively replicated factors showing significant associations with abdominal obesity in women, including aspartame intake.10
  • People who regularly consume artificial sweeteners are at increased risk of “excessive weight gain, metabolic syndrome, type 2 diabetes, and cardiovascular disease,”11 according to a 2013 Purdue review over 40 years published in Trends in Endocrinology & Metabolism

Other types of studies similarly suggest that artificial sweeteners do not contribute to weight loss. For example, interventional studies do not support the notion that artificial sweeteners produce weight loss. According to the Yale Journal of Biology and Medicine review of the scientific literature, “consensus from interventional studies suggests that artificial sweeteners do not help reduce weight when used alone.”12

Some studies also suggest that artificial sweeteners increase appetite, which may promote weight gain. For example, the Yale Journal of Biology and Medicine review found that “Preload experiments generally have found that sweet taste, whether delivered by sugar or artificial sweeteners, enhanced human appetite.”13

Studies based on rodents suggest that consumption of artificial sweeteners can lead to consuming extra food. According to the Yale Journal of Biology and Medicine review, “ Inconsistent coupling between sweet taste and caloric content can lead to compensatory overeating and positive energy balance.” In addition, according to the same article, “artificial sweeteners, precisely because they are sweet, encourage sugar craving and sugar dependence.”14

A 2014 study in the American Journal of Public Health found that “Overweight and obese adults in the United States drink more diet beverages than healthy-weight adults, consume significantly more calories from solid food—at both meals and snacks—than overweight and obese adults who drink SSBs [sugar-sweetened beverages], and consume a comparable amount of total calories as overweight and obese adults who drink SSBs.”15

A 2015 study of older adults in the Journal of the American Geriatrics Society found “In a striking dose-response relationship,” that “increasing DSI [diet soda intake] was associated with escalating abdominal obesity…”16

An important 2014 study published in Nature found that “consumption of commonly used NAS [non-caloric artificial sweetener] formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota … our results link NAS consumption, dysbiosis and metabolic abnormalities … Our findings suggest that NAS may have directly contributed to enhancing the exact epidemic that they themselves were intended to fight.”17

Diabetes and Metabolic Derangement

Aspartame breaks down in part into phenylalanine, which interferes with the action of an enzyme intestinal alkaline phosphatase (IAP) previously shown to prevent metabolic syndrome, which is a group of symptoms associated with type 2 diabetes and cardiovascular disease. According to a 2017 study in Applied Physiology, Nutrition and Metabolism, mice receiving aspartame in their drinking water gained more weight and developed other symptoms of metabolic syndrome than animals fed similar diets lacking aspartame. The study concludes, “IAP’s protective effects in regard to the metabolic syndrome may be inhibited by phenylalanine, a metabolite of aspartame, perhaps explaining the lack of expected weight loss and metabolic improvements associated with diet drinks.”18

  • See also: Mass General press release on the study, “Aspartame may prevent, not promote, weight loss by blocking intestinal enzyme’s activity”

People who regularly consume artificial sweeteners are at increased risk of “excessive weight gain, metabolic syndrome, type 2 diabetes, and cardiovascular disease,” according to a 2013 Purdue review over 40 years published in Trends in Endocrinology & Metabolism.19

In a study that followed 66,118 women over 14 years, both sugar sweetened beverages and artificially sweetened beverages were associated with risk of Type 2 diabetes. “Strong positive trends in T2D risk were also observed across quartiles of consumption for both types of beverage … No association was observed for 100% fruit juice consumption,” reported the 2013 study published in American Journal of Clinical Nutrition.20

Intestinal Dysbiosis, Metabolic Derangement and Obesity

Artificial sweeteners can induce glucose intolerance by altering the gut microbiota, according to a 2014 study in Nature. The researchers wrote, “our results link NAS [non-caloric artificial sweetener] consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage … Our findings suggest that NAS may have directly contributed to enhancing the exact epidemic [obesity] that they themselves were intended to fight.”21

A 2016 study in Applied Physiology Nutrition and Metabolism reported, “Aspartame intake significantly influenced the association between body mass index (BMI) and glucose tolerance… consumption of aspartame is associated with greater obesity-related impairments in glucose tolerance.”22

According to a 2014 rat study in PLoS ONE, “aspartame elevated fasting glucose levels and an insulin tolerance test showed aspartame to impair insulin-stimulated glucose disposal … Fecal analysis of gut bacterial composition showed aspartame to increase total bacteria…”23

Industry Science

Not all recent studies find a link between artificial sweeteners and weight gain. Two industry-funded studies did not.

  • A 2014 American Journal of Clinical Nutrition meta-analysis concluded that “Findings from observational studies showed no association between LCS [low-calorie sweetener] intake and body weight or fat mass and a small positive association with BMI [body mass index]; however, data from RCTs [randomized controlled trials], which provide the highest quality of evidence for examining the potentially causal effects of LCS intake, indicate that substituting LCS options for their regular-calorie versions results in a modest weight loss and may be a useful dietary tool to improve compliance with weight loss or weight maintenance plans.” The authors “received funding to conduct this research from the North American Branch of the International Life Sciences Institute (ILSI).”24

The International Life Sciences Institute, a nonprofit that produces science for the food industry, is controversial among public health experts due to its funding from chemical, food and pharmaceutical companies and potential conflicts of interest, according to a 2010 article in Nature.25 See also: U.S. Right to Know fact sheet about the International Life Sciences Institute.

A series of stories published in UPI in 1987 by investigative reporter Greg Gordon describe ILSI’s involvement in directing research on aspartame toward studies likely to support the sweetener’s safety.

  • A 2014 study in the journal Obesity tested water against artificially sweetened beverages for a 12-week weight loss program, finding that “water is not superior to NNS [non-nutritive sweetened] beverages for weight loss during a comprehensive behavioral weight loss program.” The study was “fully funded by the American Beverage Association,”26 which is the main lobbying group for the soda industry.

There is strong evidence that industry-funded studies in biomedical research are less trustworthy than those funded independently. A 2016 study in PLOS One by Daniele Mandrioli, Cristin Kearns and Lisa Bero examined the relationship between research outcomes and risk of bias, study sponsorship and author financial conflicts of interest in reviews of the effects of artificially sweetened beverages on weight outcomes.27 The researchers concluded, “Artificial sweetener industry sponsored reviews were more likely to have favorable results than non-industry sponsored reviews … as well as favorable conclusions.” Financial conflicts of interest were not disclosed in 42% of the reviews, and reviews performed by authors with financial conflicts of interest with the food industry (whether disclosed or not) were more likely to have favorable conclusions for the industry than reviews performed by authors without financial conflicts of interest. 

A 2007 PLOS Medicine study on industry support for biomedical research found that “Industry funding of nutrition-related scientific articles may bias conclusions in favor of sponsors’ products, with potentially significant implications for public health … scientific articles about commonly consumed beverages funded entirely by industry were approximately four to eight times more likely to be favorable to the financial interests of the sponsors than articles without industry-related funding. Of particular interest, none of the interventional studies with all industry support had an unfavorable conclusion…”28

Is “Diet” Deceptive Marketing?

In April 2015, US Right to Know petitioned the Federal Trade Commission (FTC) and the Food and Drug Administration (FDA) to investigate the marketing and advertising practices of “diet” products that contain a chemical linked to weight gain.

We argued that the term “diet” appears to be deceptive, false and misleading in violation of section 5 of the Federal Trade Commission Act and section 403 of the Federal Food, Drug and Cosmetic Act. The agencies have so far declined to act citing lack of resources and other priorities (see FDA and FTC responses).

“It’s regrettable that the FTC won’t act to halt the deceptions of the ‘diet’ soda industry. Ample scientific evidence links artificial sweeteners to weight gain, not weight loss,” said Gary Ruskin, co-director of U.S. Right to Know. “I do believe that ‘diet’ soda will go down in U.S. history as one of the greatest consumer frauds ever.”

News coverage:

USRTK press releases and posts:

Scientific References 

[1] Azad, Meghan B., et al. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. CMAJ July 17, 2017 vol. 189 no. 28 doi: 10.1503/cmaj.161390 (abstract / article)

[2] Swithers SE, “Artificial Sweeteners Produce the Counterintuitive Effect of Inducing Metabolic Derangements.” Trends in Endocrinology and Metabolism, July 10, 2013. 2013 Sep;24(9):431-41. PMID: 23850261. (abstract / article)

[3] Mattes RD, Popkin BM, “Nonnutritive Sweetener Consumption in Humans: Effects on Appetite and Food Intake and Their Putative Mechanisms.” American Journal of Clinical Nutrition, December 3, 2008. 2009 Jan;89(1):1-14. PMID: 19056571. (article)

[4] Yang Q, “Gain Weight by ‘Going Diet?’ Artificial Sweeteners and the Neurobiology of Sugar Cravings.” Yale Journal of Biology and Medicine, 2010 Jun;83(2):101-8. PMID: 20589192. (article)

[5] Brown RJ, de Banate MA, Rother KI, “Artificial Sweeteners: a Systematic Review of Metabolic Effects in Youth.” International Journal of Pediatric Obesity, 2010 Aug;5(4):305-12. PMID: 20078374. (abstract / article)

[6] Fowler SP, Williams K, Resendez RG, Hunt KJ, Hazuda HP, Stern MP. “Fueling the Obesity Epidemic? Artificially Sweetened Beverage Use and Long-Term Weight Gain.” Obesity, 2008 Aug;16(8):1894-900. PMID: 18535548. (abstract / article)

[7] Forshee RA, Storey ML, “Total Beverage Consumption and Beverage Choices Among Children and Adolescents.” International Journal of Food Sciences and Nutrition. 2003 Jul;54(4):297-307. PMID: 12850891. (abstract)

[8] Blum JW, Jacobsen DJ, Donnelly JE, “Beverage Consumption Patterns in Elementary School Aged Children Across a Two-Year Period.” Journal of the American College of Nutrition, 2005 Apr;24(2):93- 8. PMID: 15798075. (abstract)

[9] Berkey CS, Rockett HR, Field AE, Gillman MW, Colditz GA. “Sugar-Added Beverages and Adolescent Weight Change.”Obes Res. 2004 May;12(5):778-88. PMID: 15166298. (abstract / article)

[10] W Wulaningsih, M Van Hemelrijck, K K Tsilidis, I Tzoulaki, C Patel and S Rohrmann. “Investigating nutrition and lifestyle factors as determinants of abdominal obesity: an environment-wide study.” International Journal of Obesity (2017) 41, 340–347; doi:10.1038/ijo.2016.203; published online 6 December 2016 (abstract / article)

[11] Susan E. Swithers, “Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements.” Trends Endocrinol Metab. 2013 Sep; 24(9): 431–441.

[12] Yang Q, “Gain Weight by ‘Going Diet?’ Artificial Sweeteners and the Neurobiology of Sugar Cravings.” Yale Journal of Biology and Medicine, 2010 Jun;83(2):101-8. PMID: 20589192. (article)

[13] Yang Q, “Gain Weight by ‘Going Diet?’ Artificial Sweeteners and the Neurobiology of Sugar Cravings.” Yale Journal of Biology and Medicine, 2010 Jun;83(2):101-8. PMID: 20589192. (article)

[14] Yang Q, “Gain Weight by ‘Going Diet?’ Artificial Sweeteners and the Neurobiology of Sugar Cravings.” Yale Journal of Biology and Medicine, 2010 Jun;83(2):101-8. PMID: 20589192. (article)

[15] Bleich SN, Wolfson JA, Vine S, Wang YC, “Diet-Beverage Consumption and Caloric Intake Among US Adults, Overall and by Body Weight.” American Journal of Public Health, January 16, 2014. 2014 Mar;104(3):e72-8. PMID: 24432876. (abstract / article)

[16] Fowler S, Williams K, Hazuda H, “Diet Soda Intake Is Associated with Long-Term Increases in Waist Circumference in a Biethnic Cohort of Older Adults: The San Antonio Longitudinal Study of Aging.” Journal of the American Geriatrics Society, March 17, 2015. (abstract / article)

[17] Suez J. et al., “Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota.” Nature, September 17, 2014. 2014 Oct 9;514(7521):181-6. PMID: 25231862 (abstract)

[18] Gul SS, Hamilton AR, Munoz AR, Phupitakphol T, Liu W, Hyoju SK, Economopoulos KP, Morrison S, Hu D, Zhang W, Gharedaghi MH, Huo H, Hamarneh SR, Hodin RA. “Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice.” Appl Physiol Nutr Metab. 2017 Jan;42(1):77-83. doi: 10.1139/apnm-2016-0346. Epub 2016 Nov 18. (abstract / article)

[19] Susan E. Swithers, “Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements.” Trends Endocrinol Metab. 2013 Sep; 24(9): 431–441. (article)

[20] Guy Fagherazzi, A Vilier, D Saes Sartorelli, M Lajous, B Balkau, F Clavel-Chapelon. “Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l’Education Nationale–European Prospective Investigation into Cancer and Nutrition cohort.” Am J Clin Nutr. 2013, Jan 30; doi: 10.3945/ ajcn.112.050997 ajcn.050997. (abstract/article)

[21] Suez J et al. “Artificial sweeteners induce glucose intolerance by altering the gut microbiota.” Nature. 2014 Oct 9;514(7521). PMID: 25231862. (abstract / article)

[22] Kuk JL, Brown RE. “Aspartame intake is associated with greater glucose intolerance in individuals with obesity.” Appl Physiol Nutr Metab. 2016 Jul;41(7):795-8. doi: 10.1139/apnm-2015-0675. Epub 2016 May 24. (abstract)

[23] Palmnäs MSA, Cowan TE, Bomhof MR, Su J, Reimer RA, Vogel HJ, et al. (2014) Low-Dose Aspartame Consumption Differentially Affects Gut Microbiota-Host Metabolic Interactions in the Diet-Induced Obese Rat. PLoS ONE 9(10): e109841. (article)

[24] Miller PE, Perez V, “Low-Calorie Sweeteners and Body Weight and Composition: a Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies.” American Journal of Clinical Nutrition, June 18, 2014. 2014 Sep;100(3):765-77. PMID: 24944060. (abstract / article)

[25] Declan Butler, “Food Agency Denies Conflict-of-Interest Claim.” Nature, October 5, 2010. (article)

[26] Peters JC et al., “The Effects of Water and Non-Nutritive Sweetened Beverages on Weight Loss During a 12-Week Weight Loss Treatment Program.” Obesity, 2014 Jun;22(6):1415-21. PMID: 24862170. (abstract / article)

[27] Mandrioli D, Kearns C, Bero L. “Relationship between Research Outcomes and Risk of Bias, Study Sponsorship, and Author Financial Conflicts of Interest in Reviews of the Effects of Artificially Sweetened Beverages on Weight Outcomes: A Systematic Review of Reviews.” PLOS One, September 8, 2016. https://doi.org/10.1371/journal.pone.0162198

[28] Lesser LI, Ebbeling CB, Goozner M, Wypij D, Ludwig DS. “Relationship Between Funding Source and Conclusion Among Nutrition-Related Scientific Articles.” PLOS Medicine, 2007 Jan;4(1):e5. PMID: 17214504. (abstract / article)

Bayer’s Shady PR Firms: FleishmanHillard, Ketchum, FTI Consulting

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In the latest PR scandal to engulf Bayer, journalists at Le Monde reported May 9 that they obtained a “Monsanto File” created by the public relations firm FleishmanHillard listing a “multitude of information” about 200 journalists, politicians, scientists and others deemed likely to influence the debate on glyphosate in France. Le Monde filed a complaint with the Paris prosecutor’s office alleging that the document involved illegal collection and processing of personal data, spurring the prosecutor’s office to open a criminal probe. “This is a very important discovery because it shows there are objective strategies to silence strong voices. I can see they were trying to isolate me,” France’s former Environment Minister Segolene Royal, who is on the list, told France 24 TV.

“This is a very important discovery because it shows there are objective strategies to silence strong voices.”

Francois Veillerette, an environmentalist also on the list, told France 24 that it contained personal contact details, opinions and level of engagement in relation to Monsanto. “This is a major shock in France,” he said. “We don’t think this is normal.” Bayer has since admitted that FleishmanHillard drew up “‘watch lists’ of pro- or anti-pesticides figures” in seven countries across Europe, the AFP reported. The lists contained information about journalists, politicians and other interest groups. The AFP said it filed a complaint with a French regulatory agency because some of its journalists were on the list that surfaced in France.

Adding to Bayer’s PR troubles, AFP reported on May 18 that an employee of another PR firm was caught posing as a freelance journalist who worked for the BBC at the recent federal trial in San Francisco that ended with an $80 million judgment against Bayer. The woman, who was seen chatting up reporters about story ideas at the trial, did not disclose that she actually worked for FTI Consulting, a “crisis management firm” whose clients include Bayer and Monsanto.

In the wake of the “Monsanto File” revelations in France, Bayer apologized and said it suspended its relationship with the firms involved, including FleishmanHillard and Publicis Consultants, pending an investigation. “Our highest priority is to create transparency,” Bayer said. “We do not tolerate unethical behavior in our company.” However the PR companies Bayer relies upon, including FleishmanHillard and PR firms under the same corporate ownership, have histories of using underhanded tactics to promote and defend their clients – and they have done the same for Bayer.

Ketchum and FleishmanHillard hired to rehab image of GMOs

In 2013, the agrichemical industry tapped FleishmanHillard and Ketchum, both owned by Omnicom, to head up a PR offensive to rehabilitate the image of its embattled GMO and pesticide products. Monsanto selected FleishmanHillard to “reshape” its reputation amid “fierce opposition” to genetically modified foods, according to the Holmes Report. Around the same time, FleishmanHillard also became the PR agency of record for Bayer, and the Council for Biotechnology Information (CBI) — a trade group funded by Bayer (Monsanto), Corteva (DowDuPont), Syngenta and BASF — hired Ketchum public relations firm to launch a marketing campaign called GMO Answers.

Spin tactics employed by these firms included “wooing mommy bloggers” and using the voices of supposedly “independent” experts to “clear up confusion and mistrust” about GMOs. However, evidence surfaced that the PR firms edited and scripted some of the “independent” experts. For example, documents obtained by U.S. Right to Know show that Ketchum scripted posts for GMO Answers that were signed by a University of Florida professor who claimed to be independent as he worked behind the scenes with Monsanto on PR projects. A senior vice president at FleishmanHillard edited the speech of a UC Davis professor and coached her how to “win over people in the room” at an IQ2 debate to convince the public to accept GMOs. Ketchum also gave the professor talking points for a radio interview about a scientific study.

Academics were important messengers for industry lobbying efforts to oppose GMO labeling, reported the New York Times in 2015. “Professors/researchers/scientists have a big white hat in this debate and support in their states, from politicians to producers,” Bill Mashek, a vice president at Ketchum, wrote to the University of Florida professor. “Keep it up!”  The industry trade group CBI has spent over $11 million on Ketchum’s GMO Answers since 2013, according to tax records.

The spin has influenced journalists, according to the PR industry. In 2014, GMO Answers was shortlisted for a CLIO advertising award for “Crisis Management & Issue Management.” In this video, Ketchum bragged about how it nearly doubled positive media attention of GMOs and “balanced 80% of interactions”  on Twitter. Many of those online interactions are from accounts that appear independent and do not disclose their connection to industry’s PR campaign.

Although the Ketchum video claimed GMO Answers would “redefine transparency” with information from experts with “nothing filtered or censored, and no voices silenced,” a Monsanto PR plan suggests the company counted on GMO Answers to help spin its products in a positive light. The document from 2015 listed GMO Answers among the “industry partners” that could help protect Roundup from cancer concerns; in a “resources” section on page 4, the plan listed links to GMO Answers alongside Monsanto documents that could communicate the company message that “Glyphosate is not carcinogenic.”

This Ketchum video was posted to the CLIO website and removed after we called attention to it.

Omnicom’s FleishmanHillard and Ketchum: histories of deception

Why any company would put FleishmanHillard or Ketchum in front of efforts to inspire trust is difficult to understand, given their histories of documented deceptions. For example:

Until 2016, Ketchum was the PR firm for Russia and Vladimir Putin. According to documents obtained by ProPublica, Ketchum was caught placing pro-Putin op-eds under the names of “seemingly independent professionals” in various news outlets. In 2015, the embattled Honduran government hired Ketchum to try to rehabilitate its reputation after a multi-million dollar corruption scandal.

Documents leaked to Mother Jones indicate that Ketchum worked with a private security firm that “spied on Greenpeace and other environmental organizations from the late 1990s through at least 2000, pilfering documents from trash bins, attempting to plant undercover operatives within groups, casing offices, collecting phone records of activists, and penetrating confidential meetings.” FleishmanHillard was also caught using unethical espionage tactics against public health and tobacco control advocates on behalf of the tobacco company R. J. Reynolds, according to a study by Ruth Malone in the American Journal of Public Health. The PR firm even secretly audiotaped tobacco control meetings and conferences.

FleishmanHillard was the public relations firm for The Tobacco Institute, the cigarette industry’s main lobbying organization, for seven years. In a 1996 Washington Post article, Morton Mintz recounted the story of how FleishmanHillard and the Tobacco Institute converted the Healthy Buildings Institute into a front group for the tobacco industry in its effort to spin away public concern about the dangers of second-hand smoke. Ketchum also did work for the tobacco industry.

Both firms have at times worked on both sides of an issue. FleishmanHillard has been hired for anti-smoking campaigns. In 2017, Ketchum launched a spin-off firm called Cultivate to cash in on the growing organic food market, even though Ketchum’s GMO Answers has disparaged organic food, claiming that consumers pay a “hefty premium” for food that is no better than conventionally-grown food.

FTI Consulting: climate deception and more tobacco ties

FTI Consulting, the “crisis management” PR firm that works with Bayer and whose employee was caught impersonating a journalist at the recent Roundup cancer trial in San Francisco, shares several similarities with FleishmanHillard and Ketchum, including its use of covert tactics, lack of transparency and history of working with the tobacco industry.

The firm is known as a key player in ExxonMobil’s efforts to evade responsibility for climate change. As Elana Schor and Andrew Restuccia reported in Politico in 2016:

“Aside from [Exxon] itself, the most vocal resistance to the greens has come from FTI Consulting, a firm filled with former Republican aides that has helped unify the GOP in defense of fossil fuels. Under the banner of Energy in Depth, a project it runs for the Independent Petroleum Association of America, FTI has peppered reporters with emails that suggest “collusion” between green activists and state AGs, and has raised questions over InsideClimate’s Rockefeller grants.”

FTI Consulting employees have been caught impersonating journalists before. Karen Savage reported in January 2019 in Climate Liability News, “Two public relations strategists representing Exxon recently posed as journalists in an attempt to interview an attorney representing Colorado communities that are suing Exxon for climate change-related damages. The strategists—Michael Sandoval and Matt Dempsey—are employed by FTI Consulting, a firm long linked with the oil and gas industry.” According to Climate Liability News, the two men were listed as writers for Western Wire, a website run by oil interests and staffed with strategists from FTI Consulting, which also provides staff to Energy In Depth, a pro-fossil fuel “research, education and public outreach campaign.”

Energy In Depth presented itself as a “mom and pop shop” representing small energy providers but was created by major oil and gas companies to lobby for deregulation, DeSmog blog reported in 2011. The Greenpeace group uncovered a 2009 industry memo describing Energy In Depth as a “new industry-wide campaign… to combat new environmental regulations, especially with regard to hydraulic fracturing” that “would not be possible without the early financial commitments” of major oil and gas interests including BP, Halliburton, Chevron, Shell, XTO Energy (now owned by ExxonMobil).

Another feature in common with all these firms is their tobacco industry ties. FTI Consulting has “a long history of working with the tobacco industry,” according to Tobacco Tactics.org. A search of the UCSF Tobacco Industry Documents library brings up over 2,400 documents relating to FTI Consulting.

More on Bayer’s recent PR scandals

Coverage in French:

Coverage in English: